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Biomedical subjects

J A Amiguet García

Publications and source records attributed to J A Amiguet García.

6 recordsLinked to original sources
PubMed2003

[Tumoral markers and acute-phase reactants in the diagnosis of pancreatic cancer].

OBJECTIVE: To analyze the diagnostic accuracy of the following parameters in the diagnosis of pancreatic cancer: carcinoembryonic antigen (CEA), tissue plasminogen activator (TPA), carbohydrate antigen 19-9 (CA 19-9), carbohydrate antigen 50 (CA 50), alpha-1-antitrypsin (AAT), alpha-2 macroglobulin (AMG), and ceruloplasmin (CP). PATIENTS AND MENTOD: We prospectively studied 58 patients with pancreatic cancer, 40 with alcoholic pancreatitis and 40 healthy controls, in whom the above-mentioned parameters were analyzed. Receiver operating characteristic curves (ROC curves) were analyzed. RESULTS: The specificity of TPA, CA 19-9 and CA 50 in the differential diagnosis between pancreatic cancer and chronic pancreatitis was 87.5%, 90% and 95% respectively, with a sensitivity of nearly 90%. Although levels of AAT, AMG and CP were higher in patients with cancer than in those with pancreatitis, their specificity was lower, approximately 65%. CEA and TPA showed a positive association with the presence of metastases. CONCLUSION: TPA, CA 19-9 and CA 50 were useful in the differential diagnosis between pancreatic cancer and chronic pancreatitis.

Acute-Phase Proteins↗
PubMed2003

[Osteonecrosis and HIV].

An increase of the incidence of osteonecrosis in subjects infected with the HIV has been reported. It is unknown if osteonecrosis is an HIV infection consequence, or just the consequence of so many risk factors present among HIV infected subjects. We report five osteonecrosis cases found in our series of 534 HIV patients, and we review the related bibliography. All cases have some conventional risk factor different to the HIV or the antiviral treatment. We can't conclude antiviral treatments are not involved in osteonecrosis, but they have been the only risk factor in none of our patients.

Adult↗
PubMedDate not supplied

[Nutritional status of the HIV patient. Description and clinical course of a group of patients over a year].

GOAL: To know the nutritional and immunological status of a sample of patients infected by HIV and their evolution over a one-year period. Relationship between nutritional status, immunological status and clinical evolution. METHOD: Longitudinal descriptive study of 30 HIV-infected patients. Anthropometric evaluation (weight, height, skin folds, arm circumference) and immunological assessment (CD4 and CD4/CD8). STATISTICAL ANALYSIS: means, absolute and relative frequencies, Student's T test. RESULTS: 30 patients, 73.3% males and 27.7% female. Mean age 34.7 years. Initial nutritional assessment: 30% of patients had normal weight, 36.7% presented mild undernourishment, 16.7% moderate undernourishment, 6.7% were overweight and 10% were obese. The evolution of CD4 and CD4/CD8 levels was not significantly influenced by nutritional status. CONCLUSIONS: The patients in the study presented a deterioration of their nutritional status, as assessed by triceps skin fold. The nutritional status of the HIV-infected patients in our study is not dependent on their immunological status. The diagnosis and treatment of their de-nourishment on diagnosis of HIV infection will contribute to the prevention of complications, thus reducing the human and health-care costs. An increase in food intake, on its own, does not improve the condition of the patients, indicating the need to provide them with the necessary dietary supplements from the early stages of illness.

Adult↗
PubMedDate not supplied

[Diet survey and evaluation of ingested nutrients in a group of HIV patients].

OBJECTIVE: To study the relationship between nutritional status, immunological condition, clinical progress and food consumption in a group of patients infected with HIV. METHOD: Longitudinal descriptive study of 30 HIV/AIDS patients. Anthropometric assessment (weight, height, skin folds, upper arm circumference). The intake of nutrients was calculated using a one-week dietary record. RESULTS: The mean amount of energy intake is 2,791 kcal with a 13.48% of protein, 40.12% of carbohydrates and 45.89% of lipids. The group of patients with weight loss presented a significantly greater proportion of proteins than group with normal weight. Patients with Kwashiorkor-like malnutrition presented an intake of proteins which was significantly lower than the group of well-nourished patients. The group of those whose nutritional status improved presented a significantly higher mean percentage of proteins in the diet than the other groups. CONCLUSIONS: The amount of the energy intake by patients is higher than that recommended. The diets show an excessive consumption of fats and a shortage of carbohydrates and proteins. Deficits are observed in vitamin B6 and vitamin E, magnesium and zinc. The increase in intake, by itself, does not improve the health status of the patients, indicating the need to provide them with the necessary dietary supplements from the early stages of their condition.

Adult↗