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Biomedical subjects

J A Carson

Publications and source records attributed to J A Carson.

44 records · Page 3Linked to original sources

Gastroesophageal reflux in childhood. The dilemma of surgical success.

Successful surgical correction of gastroesophageal reflux has prompted frequent and early referral of children for antireflux surgery. This report describes the results and defines the complications in a series of children treated surgically for gastroesophageal reflux. Methods are suggested to reduce the occurrence of these postoperative complications. In five years (1977-1981), 117 children, 3 weeks to 16 years old, were operated on for gastroesophageal reflux at The Oklahoma Childrens Memorial Hospital. Nissen fundoplication was performed on 111 of them. Patients have been followed for 3 months to five years. At most recent examination, clinical success (remission of symptoms) has been accomplished in 81 of 92 patients (90%). In 86 patients evaluated radiographically, gastroesophageal reflux was absent in 83 and persistent in 3. There were no operative deaths. Twenty-three major complications occurred in 21 patients, 13 of whom required reoperation. These major complications were paraesophageal hiatal hernia (ten patients), small bowel obstruction (eight patients), and wrap malalignment (5 patients). Observations of and reoperation on these children suggests the following necessary steps for avoidance of complications in children: (1) Nissen fundoplication in childhood should be accompanied by an accurate multi-suture crural repair and by suture fixation of the fundal wrap to the crura and to the abdominal surface of the diaphragm; (2) appropriate alignment of the fundal wrap and of the crural repair is best accomplished with a large indwelling esophageal bougie of sufficient size to efface and blanche the esophageal musculature; and (3) appropriate care in avoiding small bowel obstruction mandates meticulous avoidance of trauma to the liver capsule and small bowel serosa.

Adolescent↗

Improved results with hepatic portoenterostomy: a reassessment of its value in the treatment of biliary atresia.

As reported in 1974, the initial experience at the Oklahoma Children's Memorial Hospital with the Kasai procedure for biliary atresia was unsatisfactory. A subsequent series of 20 patients, in which 50% of the patients are alive and improved and 25% jaundice-free, is described. Modifications of the initial operative technique have been utilized. Postoperative complications in the ten children with sustained bile flow included cholangitis in five, hyponatremia in four, esophageal variceal hemorrhage in two, stomal bleeding in two, and gallbladder conduit malfunction in two patients. The improved outcome is attributed to earlier diagnosis and correction, attention to operative details, intensive postoperative nutritional support, and prompt recognition and management of complications.

Adolescent↗

Hepatoportal sclerosis in childhood: a mimic of extrahepatic portal vein obstruction.

In the absence of cirrhosis, most children with portal hypertension and bleeding esophageal varices have extrahepatic portal vein occlusion. In the past 2 yr this clinical picture has been mimicked by two children with hepatoportal sclerosis causing their variceal hemorrhage. Hepatoportal sclerosis has been well described in adults. It is manifested by splenomegaly, portal hypertension, and variable ascites and hepatomegaly. Liver histology is initially normal but subsequently shows periportal fibrosis without cirrhosis. Hepatic manometrics indicate a presinusoidal block, but angiography demonstrates a patient portal vein. Typically there is abrupt narrowing of the intrahepatic portal branches, giving a "withered tree" appearance. These findings are illustrated by two children who presented with esophageal variceal bleeding at 21 and 20 mo of age, respectively. They are the youngest reported cases of hepatoportal sclerosis. The etiology of hepatoportal sclerosis is uncertain, but the disease appears to be only slowly progressive. Control of variceal bleeding by central portosystemic shunts in this condition is associated with a 50% incidence of hepatic encephalopathy. Therefore alternate methods of therapy need be considered. Endoscopic injection sclerotherapy successfully controlled variceal bleeding in one child reported here. Hepatoportal sclerosis is a distinct entity and must be considered in the differential diagnosis of portal hypertension in infants and children.

Biopsy↗

Pediatric gastroesophageal reflux: age-specific indications for operation.

Pediatric gastroesophageal reflux is common and its complications may be serious. The diagnosis is being suspected and confirmed with increasing frequency in children because of heightened awareness of the symptoms peculiar to pediatric patients. Thirty-one children who underwent Nissen fundoplication for gastroesophageal reflux are reviewed. Diagnosis was obtained by barium meal, isotope scanning, esophagoscopy and pH monitoring. Failure to thrive, recurrent pneumonia, apnea, feeding difficulty and esophageal stricture unresponsive to medical management were the indications for operation. Children with brain damage or previous repair of esophageal atresia are at high risk for gastroesophageal reflux and its complications. A protective fundoplication is a desirable adjunct to feeding gastrostomy in brain-damaged children. Fundoplication eliminated reflux in 30 of 31 patients, relieved symptoms in 28 and improved symptoms in 2. Nissen fundoplication is a safe and effective surgical procedure for correction of gastroesophageal reflux in children.

Adolescent↗

Taste acuity and food attitudes of selected patients with cancer.

Patients with cancer may display taste abnormalities. In this study, abnormalities observed before treatment involved decreased salt and sweet sensitivity. For some thresholds, greater abnormalities were observed among men and women, among patients with colon cancer than among those with breast cancer, and among those with a greater extent of disease. Observations of slight increases in thresholds for sour detection and bitter recognition during the early treatment period and normalization of high sweet recognition thresholds after two weeks of treatment suggest that additional changes in taste acuity may accompany short-term treatment with 5'fluorouracil. However, absence of a correlation of taste changes with changes in food preferences points to the role of other factors in determining patients' food preferences during such treatment. Consideration of the incidence of taste abnormalities in these groups of patients with cancer and observation of altered food attitudes among patients receiving 5-fluorouracil does provide a basis for general recommendations for serving foods which will appeal to these patients.

Adult↗

Segmentation of gated Tl-SPECT images and computation of ejection fraction: a different approach.

BACKGROUND: We describe a set of image processing algorithms and mathematical models that can be advantageously used in schemes for the segmentation of thallium-201-single photon emission computed tomography (SPECT) images and for computation of left ventricular ejection fraction (EF). METHODS: The system consists of two independent blocs for image segmentation and computation of function. The former is based on a multiresolution elliptical coordinate transformation and dynamic contour tracking. Computation of EF is formulated on the basis of both the endocardial and epicardial contours, and we compare this formulation with that using only the endocardial border for images with low signal-to-noise ratios. The accuracy of border detection was validated against manual border tracing on FDG-PET images, simulated Tl-201-SPECT images where the true underlying borders were known, and actual Tl-201-SPECT images. Finally, we compared EFs computed for FDG-PET, technetium-99m-SPECT and Tl-201-SPECT with those obtained from planar gated blood pool imaging. RESULTS: The automatically obtained results always were within the manual uncertainty range. Agreement between myocardial volumes from positron emission tomography and automatically obtained values from the simulated Tl-201-SPECT images was excellent (r = 0.95, n = 32). Agreement between EFs from planar gated blood pool imaging and the other image modalities was good (FDG-PET: y = 5.89 + 1.21x, r = 0.92, see = 6.24, n = 19, Tc-99m-SPECT: y = -3.86 + 1.06x, r = 0.88, see = 7.78, n = 9, Tl-201-SPECT: y = 17.8 + 0.81x, r = 0.77, see = 7.44, n = 26). For noisy input data the combined use of information from epicardial and endocardial contours gives more accurate EF values than the traditional formula on the basis of the endocardial contour only. CONCLUSIONS: Alternate approaches for segmentation and computation of function have been presented and validated. They might also be advantageously incorporated into other existing techniques.

Algorithms↗