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Biomedical subjects

J A Caylà Buqueras

Publications and source records attributed to J A Caylà Buqueras.

6 recordsLinked to original sources
PubMed1992

[Influence of the HIV (+) cases on the epidemiology of infantile tuberculosis in Barcelona].

OBJECTIVE: To understand better the characteristics of tuberculosis (TBC) in children and to identify sources of infection. DESIGN: Crossover study. SITE. At the community level in the city of Barcelona. PATIENTS: Children under 15 with tuberculosis, who were diagnosed between Oct 1, 1989 and Sept 30, 1990 and were resident in Barcelona. MAIN MEASUREMENTS AND RESULTS: Among the 78 cases found, we identified the source of infection for 26 children (33.3%). 6 of these (23.1%) had been infected by three cases of HIV+. A relationship was posited between the economic level of the population and the incidence of TBC. This was confirmed by the economic level of the families (80% of the sources of infection identified belonged to professions requiring few or no qualifications) and where they lived, given that the specific rate for children under 15 in the most depressed social-economic area (Ciutat Vella) was 206 per 100,000, whereas in the wealthiest area (Sarrià-Sant Gervasi) the rate was 4.3 per 100,000. CONCLUSIONS: This study makes clear the importance of investigating the contacts of children with tuberculosis. It should be fundamental for the TBC control programmes to focus closely on those with HIV. They are much more likely to contract and spread TBC to the least protected groups of the population, especially to the children of poor families.

Adolescent↗
PubMedDate not supplied

[Extension of reporting AIDS cases in Catalonia: study based on requests for CD4 lymphocyte count and prescription of antiretroviral drugs].

BACKGROUND: To ascertain the degree to which AIDS is officially reported in Catalunya. METHOD: The request for T CD4+ white blood cell counts and the prescribing of antiretroviral drugs in seven university hospitals in Catalunya from January 1, 1994 to June 31, 1994 were used as data-comparison sources. A case was considered to not have been reported when the clinical history showed a diagnosis of AIDS (according to the Europe 93 definition) and the case in question did not show up on the AIDS Registry for Catalunya. RESULTS: Of the 1,370 cases studied, 50 unreported AIDS cases were found. In all, 98.6% of all cases were found to have been reported, for a 95% confidence interval (95% CI): 98.2-99.0. Most of the unreported cases were males (72%) averaging 37.3 years of age (HCA: 11.8), 52% of whom were injected drug users (IDU's), extrapulmonary tuberculosis being the disease most often diagnosed (16%), 81.4% having been found to have a T CD4+ white blood cell count of 200 WBC/mm3 or below. 92% of these cases were detected based on T CD4+ white blood cell counts. CONCLUSIONS: The degree of completeness found is considered to be adequate. It is recommended that the white blood cell count records being used for this type of studies.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

[Survival of patients with HIV-related tuberculosis. Study of mortality during the first 9 months of treatment].

BACKGROUND: Among the individuals with tuberculosis who are infected with HIV a high degree of lethality has been found to exist during the first few weeks following the start of tuberculosis treatment. In this study, the survival of these individuals is studied within the framework of a retrospective cohort study. METHODS: This study included 1135 subjects infected by HIV over age fifteen and residents of Barcelona who were registered by the Barcelona Tuberculosis Prevention and Control Program and were diagnoses within the 1988-1993 period. The variables analyzed were age, gender, former imprisonment, municipal district, risk group, percentage of T CD4+ lymphocytes, tuberculin test, AIDS diagnosis (as per CDC-1987), X-ray pattern, bacteriology and part of the body affected by the tuberculosis. The Cox semiparametric method, the Kaplan-Meir curves and the log-rank test were employed. RESULTS: A 77% probability of survival during the first nine months was found to exist, with wide-ranging variations among the different subgroups. The only significant variables in the Cos multivariate model were AIDS, the percentage of T CD4+ lymphocytes and their interaction. The risk of death for an individual not having AIDS and a T CD4+ lymphocyte percentage of 14% or lower was 7.69 times higher than the risk of dying for an individual not having AIDS who had a T CD4+ lymphocyte percentage of above 14%. CONCLUSIONS: The survival of those individuals having tuberculosis who are infected with HIV varies greatly. Those who died in the short term were diagnosed as having AIDS on starting the tuberculosis treatment and who also had a T CD4+ lymphocyte percentage of 14% or lower.

AIDS-Related Opportunistic Infections↗