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Biomedical subjects

J A Cornet

Publications and source records attributed to J A Cornet.

7 recordsLinked to original sources
PubMed1992

Images of numbers, or "When 98 is upper left and 6 sky blue".

Some people declare that they possess a personal visual representation of numbers: some automatically "see" the numbers they are confronted with in a precise location in a structured mental space, others "associate" specific colours with given numbers. Such visuo-spatial representations of numbers were first described by Galton in 1880 but have since received little attention from psychologists. It is the aim of this article to describe these mental representations and discuss their role in number processing. The authors first review Galton's observations, and then present their own. Finally, they discuss the relevance of these visuo-spatial representations in relation to contemporary debates on number representation and calculation.

Adult↗
PubMed1991

Dot counting by brain damaged subjects.

In this study, we examine how brain damaged adults (aphasics, right-brain lesioned subjects (RBD), and demented subjects) perform a basic education skill: determining the cardinality of different sets of objects (dots). The RBD subjects encountered more difficulty with the spatial correspondence components of the task (correct pointing to the dots), while the aphasics experienced more difficulty with the verbal components (the production of the correct number-word sequence). The deficit evidenced by the demented patients was less systematic. However, qualitative analyses of patients' behavior suggested an organization that tended to minimize the impact of their cognitive deficits on the object-counting task, and an analysis of their counting indicates that the basic counting principles proposed by Gelman (1982) and Fuson (1988) may be preserved.

Aphasia↗
PubMed1981

Documentation of Epstein-Barr virus infection in immunodeficient patients with life-threatening lymphoproliferative diseases by clinical, virological, and immunopathological studies.

Multiple methods, pedigree analysis, clinical evaluation, and Epstein-Barr virus (EBV)-specific serology, EBV DNA hybridization of tissues to probe for viral genome, staining of touch imprints for EBV nuclear-associated antigen, establishment of spontaneous infected B-cell lines from peripheral blood or tissues, examination of peripheral blood smears, and hematopathology studies, were used to study seven patients with the X-linked lymphoproliferative syndrome and seven additional patients with life-threatening EBV-associated diseases. These studies demonstrated EBV in the tissues of all 14 patients and immunodeficient antibody responses to EBV were documented. This virus can produce various life-threatening lymphoproliferative diseases in a variety of immunodeficient patients.

Adolescent↗
PubMed1981

Terminal deoxynucleotidyl transferase-containing cells in peripheral blood: implications for the surveillance of patients with lymphoblastic leukemia or lymphoma in remission.

An indirect immunofluorescence assay was used to quantitate TdT-containing (TdT+) cells in the mononuclear leukocyte fraction of peripheral blood from normal subjects and patients with acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LL). In normal children (10) and adults (10), 0.036% +/- 0.014% (mean +/- SD) and 0.030% +/- 0.015% TdT+ cells were found. In peripheral bloods from 10 children receiving chemotherapy for tumors other than ALL or LL, 0.040% +/- 0.039% TdT+ cells were found. Serial determinations were performed on 15 patients with ALL or LL who were in clinical remission. Eight of these patients remained in continuous remission and always had fewer than 0.11% TdT+ cells in their peripheral blood. Three patients who developed systemic relapse were found to have progressively rising numbers of TdT+ cells in their peripheral blood prior to clinical evidence of relapse. All 3 of these patients had greater than 0.1% TdT+ cells in their peripheral blood from 3 to 8 wk prior to clinical relapse. In 3 other patients, localized extramedullary relapse developed, but no trend was found on serial TdT determinations. Thus, the indirect immunofluorescence assay for TdT detects a small population of cells in normal peripheral blood. In patients with ALL, progressive increases above this normal level were associated with subsequent bone marrow relapse.

Animals↗
PubMed1980

X-linked lymphoproliferative syndrome registry report.

Immune deficiency, especially to the Epstein-Barr virus, and increased susceptibility to fatal infectious mononucleosis, acquired agammoglobulinemia, and lymphoma are the cardinal features of the X-linked lymphoproliferative syndrome. Since the establishment of the XLP Registry in September, 1978, 59 affected males in seven unrelated kindreds were comprehensively studied. A spectrum of lymphoproliferative phenotypes was observed. Thirty-four patients (57%) died from infectious mononucleosis, eight (14%) had fatal infectious mononucleosis with lymphoma (immunoblastic sarcoma), nine (15%) had depressed immunity following EBV infection, and eight (14%) developed lymphoma. Several patients with XLP lacked EBV antibodies despite infection by EBV. The results of this study suggest that EBV can be an oncogenic agent in patients who are immune deficient with XLP.

Adolescent↗