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Biomedical subjects

J A Cortez

Publications and source records attributed to J A Cortez.

13 recordsLinked to original sources
PubMed1988

Improved survival using oxygen free radical scavengers in the presence of ischemic bowel anastomosis.

A rat model was developed to determine the efficacy of oxygen free radical scavenger compounds in improving small bowel anastomotic healing in ischemia. 50 Sprague-Dawley rats underwent laparotomy and were divided into groups: I. sham operation; II. ischemia produced by ligation of mesenteric vessels along 3-5 cm of bowel; III. bowel transection and anastomosis; IV. ligation of vessels with bowel transection and anastomosis; V. ligation of vessels, bowel transection and IV administration of superoxide dismutase (SOD) (5000 U/kg) prior to anastomosis. All surviving animals were sacrificed after 2 weeks. Anastomotic tensile strength and histology were evaluated. Percent survival and the average length of survival for all groups is seen in the table below. (table: see text) A significant decrease in survival was present with the anastomotic group and the ischemic anastomotic group when compared with controls. An improved survival similar to ischemia alone was present in SOD group. No significant difference was noted between SOD and control groups. The results of this study indicate an improved survival rate and length of survival similar to controls in animals undergoing ischemic and penetrating injury to the bowel with the use of oxygen free radical scavenger compounds prior to anastomosis.

Anastomosis, Surgical↗
PubMed1983

Immunosuppression with cyclosporine. A new approach to improve patency of venous allografts.

In cases in which an autogenous vein is not available, the venous allograft still represents an interesting alternative; however, early occlusion of the allograft is the rule. Forty-five mongrel dogs received jugular allografts transplanted into the carotid artery. Group 1 (n = 6) received no immunosuppression; group 2 (n = 5) received systemic azathioprine (2.5 mg/kg/day). In group 3 (n = 10) the grafts were pretreated with cyclosporine at 4 degrees C, and in group 4 (n = 9) the grafts were cryopreserved in a solution of 15% dimethyl sulfoxide and cyclosporine (50 mg/L) at -196 degrees C prior to implantation. Groups 3 and 4 received azathioprine as in group 2. Group 5 received cyclosporine systemically (15 to 20 mg/kg/day). Patency rates at one month (groups 1 and 2, 0%; group 3, 57.1%; groups 4 and 5, 100%) indicate that cyclosporine improves venous allograft survival both when used systemically and as a graft pretreatment modality.

Animals↗
PubMed1980

New techniques of gastrointestinal anastomoses using the EEA stapler.

A new instrument for performing end-to-end, inverted stapled anastomoses in the gastrointestinal tract is described. Its advantages and disadvantages are also discussed. Techniques to avoid a proximal enterotomy or colotomy are described in Billroth I gastrectomy and end-to-side ileocolostomy, and experience with 30 anastomoses, their hazards, and complications are reported. The instrument creates a better anastomosis and shortens the operative time.

Colectomy↗
PubMedDate not supplied

Surgical techniques for gastroesophagostomy with the EEA stapler.

The techniques using the EEA stapler for gastroesophageal anastomoses are described. The instrument saves time, in our opinion, and creates a better anastomosis, which can be inspected under direct vision. No intra- or postoperative complications were noted in this small group of patients.

Esophageal Diseases↗
PubMedDate not supplied

Traumatic aorto-left renal vein fistula.

Most patients with traumatic or spontaneous venous fistula can be managed safely and effectively by conventional operative techniques. Infrequently total circulatory arrests with hypothermia may be used to correct this defect. The ideal treatment is transection of the fistula with preservation of the kidney function. A traumatic aorto-left renal vein fistula was successfully treated with preservation of renal function. Diagnosis was made early by the presence of a bruit and a wide pulse pressure. The diagnosis was confirmed on aortography and oxygen saturation in the left renal vein. The fistula was closed by the conventional operative technique without hypothermia or circulatory arrest.

Abdominal Injuries↗