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Biomedical subjects

J A De Pedro

Publications and source records attributed to J A De Pedro.

6 recordsLinked to original sources
PubMed2007

Biological response of new activated acrylic bone cements with antiseptic properties. Histomorphometric analysis.

The biological response to an acrylic bone cement cured with 4,4'-bis-dimethylamino benzydrol (BZN) as activator of reduced cytotoxicity and antiseptic properties, has been carried out and compared with that obtained for CMW 3 cement. Histomorphometrical data (undecalcified trichromic Goldner staining) were obtained by measuring the most significant variables at the bone-cement interface. Quantitative results of tissue response revealed that newly formed bone and connective tissue were maximum at 4 weeks whereas bone marrow increased with time of implantation for both cements. Statistical analysis (p < 0.05) showed no significant differences in newly formed bone and bone marrow with time and between both groups, however, connective tissue significantly decreased between 4 weeks and 12 weeks for BZN cement, and between 12 weeks and 24 weeks for CMW3. By comparing both cements at each time, lower significant percentage of connective tissue at the bone-cement interface of the BZN cement, was obtained at 12 and 24 weeks, however, a very low amount of connective tissue was found for both cements. All the results indicate that the new activated system could be applied clinically in a relatively short time, after the corresponding preclinical study.

Animals↗
PubMed2005

Pulsed electromagnetic fields induce peripheral nerve regeneration and endplate enzymatic changes.

An experimental study was carried out in rats with the purpose of demonstrating the capacity of pulsed electromagnetic fields (PEMFs) to stimulate regeneration of the peripheral nervous system (PNS). Wistar and Brown Norway (BN) rats were used. Direct sciatic nerve anastomoses were performed after section or allograft interposition. Treatment groups then received 4 weeks of PEMFs. Control groups received no stimulation. The evaluation of the results was carried out by quantitative morphometric analysis, demonstrating a statistically significant increase in regeneration indices (P < 0.05) in the stimulated groups (9000 +/- 5000 and 4000 +/- 6000) compared to the non-stimulated groups (2000 +/- 4000 and 700 +/- 200). An increase of NAD specific isocitrate dehydrogenase (IDH) activity was found along with an increase in the activity of acetyl cholinesterase at the motor plate. The present study might lead to the search for new alternatives in the stimulation of axonal regenerative processes in the PNS and other possible clinical applications.

Acetylcholinesterase↗
PubMed2003

Periosteal ganglion in a child.

A case of periosteal ganglion in a 10-year-old boy is reported. The diagnosis of periosteal ganglion was made on roentgenographic and MR appearance and histologic evidence. The patient was successfully treated by excision. The follow-up examination showed no recurrence. Periosteal ganglia must be considered a cause of expanding cortical erosions. This lesion may mimic other peripheral expanding lesions.

Bone Cysts↗
PubMed1995

Distal vascular pedicle-hemisoleus to tibial length ratio as a main predictive index in preoperative flap planning.

The management of severe compound tibial fractures is aimed at obtaining osseous consolidation, proper cutaneous and muscular cover, absence of infection and restoration of limb function. A knowledge of the cutaneous and muscular vascularisation allows the surgeons to use many flaps in a rational and predictable manner. One of the most commonly used flaps is the soleus muscular flap. This may be used as a proximally or distally based muscular flap and the use of a hemisoleus flap has also been described. A morphometric analysis of the relation between tibial length and soleus vascular pattern provides a simple and reliable method for planning this flap preoperatively. The study was performed on fresh and preserved cadavers.

Cadaver↗
PubMed1992

Internal fixation of ulnar fractures by locking nail.

Fractures and dislocations of the forearm are commonly observed in trauma clinics. With time, there will probably be significant increases in fractures of the forearm associated with traffic and sports. The efficacy of the treatment of ulnar fractures by a new locking nail, developed by Lefevre in Strasbourg, was tested in 20 patients. The fractures were severely displaced ulnae or both bones of the forearm. The minimum follow-up period was six months. The average age of the patients was 33.5 years (range, 14-77 years). The nail is placed into the ulna proximally. Locking is achieved by two screws placed at the proximal and distal end of the nail. The healing time for the fractures of both bones of the forearm ranged from 75 days to 20 weeks, with an average of 15 weeks. Healing time for the ulnar fractures ranged from eight to 20 weeks, with an average of ten weeks. The advantages of this nail were easy closed technique, compression effects at the fracture site, and enough stability so that an external support and tourniquet, in isolated ulnar fractures, were not necessary.

Adolescent↗