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Biomedical subjects

J A Engelbrecht

Publications and source records attributed to J A Engelbrecht.

3 recordsLinked to original sources
PubMed1990

Takayasu's arteritis in western South Dakota.

Takayasu's arteritis is an inflammatory condition affecting the large arteries. While most reported cases are from Latin America and the Orient, the disease has a worldwide distribution. Patients frequently complain of claudication, arthralgias and fatigue, and physical examination is remarkable for vascular bruits and pulse deficits. The diagnosis is established by angiography and a typical clinical presentation. Prednisone is adequate treatment in the majority of patients. Cyclophosphamide and vascular bypass surgery are reserved for more severe cases. Two cases identified in western South Dakota are presented followed by a detailed literature review.

Adolescent↗
PubMed1978

Septic bursitis.

Explore the source record for details and available documents.

Bursitis↗
PubMed1975

Enhancement of neural and thermal vasoconstriction by prostaglandin B1.

The vascular effects of prostaglandin B1 (PGB1) were studied during constant-flow perfusion of the canine hindpaw. The effects of PGB1 (50-200 ng/kg/min ia) on systemic and hindpaw perfusion pressures and on responses to local cooling (4 degrees C for 90 sec) and local heating (45 degrees C for 60 sec) were measured in 15 dogs. PGB1 (50-100 ng/kg/min) decreased perfusion pressure without any significant effect on systemic arterial pressure. Higher concentrations of PGB1 (200 ng/kg/min) elevated perfusion pressure to control values. The pressor responses to local cooling were increased from 11 to 32 mmHg while the dilator responses to local heating and nitroglycerin were reduced during infusions of PGB1. PGB1 also enhanced the pressor responses to norepinephrine or tyramine. These findings support the conclusions that (1) low concentrations of prostaglandin B1 enhance neurotransmitter release with minimal effects on vascular smooth muscle cells and (2) these effects are not secondary to increased perfusion pressures or vascular wall stresses since infusions of PGB1 resulted in vasodilation.

Animals↗