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J A Fleming

Publications and source records attributed to J A Fleming.

67 records · Page 4Linked to original sources
PubMed1980

Causes of death in schizophrenia and manic-depression.

Causes of death were studied in a cohort of 200 schizophrenic, 100 manic, and 225 depressive patients who were followed in a historical prospective study. These patients were admitted between 1934 and 1944 and were studied 30 to 40 years later. Five cause of death categories were considered in this analysis: (1) unnatural deaths, (2) neoplasms, (3) diseases of the circulatory system, (4) infective and parasitic diseases, and (5) other causes. For each cause of death, the expected number of deaths was calculated from vital statistics for the State of Iowa for the time period of follow-up. Observed numbers of deaths were contrasted with expected numbers of deaths to assess statistical significance for each diagnostic group. There was a significant excess of unnatural deaths in all diagnostic groups in both sexes, with the exception of female manics. This group, however, did show a significant excess of circulatory system deaths. Both male and female schizophrenics showed a substantial excess of infective disorder deaths.

Bipolar Disorder↗
PubMed1979

Long-term outcome of major psychoses. I. Schizophrenia and affective disorders compared with psychiatrically symptom-free surgical conditions.

We conducted a 30- to 40-year field follow-up of 685 patients with schizophrenia, affective disorders, and nonpsychiatric conditions. Long-term outcome was analyzed in terms of the patients' marital, residential, occupational, and psychiatric status. On the whole, psychiatric patients showed a significantly poorer outcome than the surgical controls. On the basis of long-term outcome, schizophrenia, and affective disorders, selected according to the specified research criteria, were significantly different: schizophrenia definitely showed poorer outcome than affective disorders. However, no significant differences in all four outcome variables were found between mania and depression. We hope that the present data on long-term outcome of the typical cases can be used to compare outcome of other psychiatric disorders, such as undiagnosed psychoses, having mixtures of schizophrenic and affective features. In doing this, we hope to charify our understanding of undiagnosed psychoses and their relationship to schizophrenia and affective disorders.

Adult↗
PubMed1967

A critical and comparative study of methods of isolating tumour cells from the blood.

From the large number of techniques described for isolating tumour cells from the blood, five have been selected because they were those most widely used by previous workers and can be performed with a minimum of special apparatus. These techniques have been assessed for their efficiency in retaining tumour cells added to blood samples, in eliminating normal blood cells, and in preserving the morphology of the retained cells. Those techniques which depend on the differing densities of blood and tumour cells were reliable in recovering tumour cells unaltered morphologically and at the same time eliminating most of the blood cells. Because of its simplicity the silicone flotation technique has been preferred for routine use.

Acetates↗