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Biomedical subjects

J A Freed

Publications and source records attributed to J A Freed.

6 recordsLinked to original sources
PubMed1991

Hypercoagulability. Should every patient with venous thrombosis be tested?

Tests for anticoagulant protein deficiencies have a low predictive value for venous thrombosis in the general population. Such testing should be done only in patients with recurrent thrombosis, a family history of thrombosis, or atypical features such as young age at presentation or unusual site. Decreased fibrinolysis is another defect often seen in patients with venous thrombosis, but it lacks sufficient specificity to have a high predictive value. The presence of antiphospholipid antibodies has a fairly high predictive value, and testing beyond the partial thromboplastin time may be justified in patients who have (1) arterial thrombosis or (2) a history of fetal demise or recurrent spontaneous abortions.

Animals↗
PubMed1991

Desquamative interstitial pneumonia associated with chrysotile asbestos fibres.

The drywall construction trade has in the past been associated with exposure to airborne asbestos fibres. This paper reports a drywall construction worker with 32 years of dust exposure who developed dyspnoea and diminished diffusing capacity, and showed diffuse irregular opacities on chest radiography. He did not respond to treatment with corticosteroids. Open lung biopsy examination showed desquamative interstitial pneumonia. Only a single ferruginous body was seen on frozen section, but tissue examination by electron microscopy showed an extraordinary pulmonary burden of mineral dust with especially high concentrations of chrysotile asbestos fibres. This report emphasises the need to consider asbestos fibre as an agent in the aetiology of desquamative interstitial pneumonia. The coexistent slight interstitial fibrosis present in this case is also considered to have resulted from exposure to mineral dust, particularly ultramicroscopic asbestos fibres.

Asbestos↗
PubMed1985

Pseudomembranous necrotizing bronchial aspergillosis. A variant of invasive aspergillosis in a patient with hemophilia and acquired immune deficiency syndrome.

A 15-yr-old male hemophiliac developed the acquired immune deficiency syndrome (AIDS). His terminal illness was characterized by rapidly progressive respiratory failure with intermittent wheezing, nonresponsive to bronchodilator and steroid therapy. Postmortem examination revealed a pseudomembrane covering the mucosa of the lower trachea and bronchi of both lungs. This pseudomembrane was composed predominantly of fungal hyphae speciated as Aspergillus niger. There was widespread transmural necrotizing bronchitis and fungal invasion that extended to involve a narrow zone of peribronchial tissues. The intervening lung parenchyma was free of fungal disease. This unique form of bronchitis is a distinct variant of invasive aspergillosis and merits recognition because of its clinical and prognostic implications.

Acquired Immunodeficiency Syndrome↗