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Biomedical subjects

J A Freitas

Publications and source records attributed to J A Freitas.

At least 19 recordsLinked to original sources
PubMed2001

Oral clefts and vitamin supplementation.

OBJECTIVES: The evidence linking low levels of folic acid and orofacial clefting (OFC) is presently equivocal. There is stronger evidence for the role of folic acid supplementation in protection against the occurrence and recurrence of neural tube defects. The present investigation tested the hypotheses that cleft lip, cleft palate, or both are inversely associated with maternal intake of dietary and supplemental vitamins during the periconceptional period and first 4 months of pregnancy in a Brazilian population. DESIGN: A population-based, case-control study of cleft lip with or without cleft palate (CL(P)) and isolated cleft palate (CP) in a Brazilian population. In structured interviews, case histories were taken from the mothers of a consecutive sample of 450 infants born with nonsyndromic OFC. RESULTS: Mothers who had children with CL(P) were less likely to have been supplemented during the periconceptional period. The statistical significance of the difference in prevalence of the use of supplements between mothers of patients and of controls was greater for the CL(P) group: p < .05 for CP and p < .001 for CL(P). Multivariate analysis confirmed this finding of a protective effect for both types of orofacial cleft. CONCLUSIONS: The use of vitamin supplements in the first 4 months of pregnancy was suggestive of a protective effect against the occurrence of CP and CL(P) in this population. The significance of an association between multivitamin supplementation and OFC and the possible role of gene/environment interaction are discussed.

Brazil↗
PubMed2001

[Prevalence of oral clefts from 1975 to 1994, Brazil].

OBJECTIVE: To estimate the prevalence of oral clefts in Brazil categorized by etiology and geographical region. METHODS: Case reports of oral cleft in newborns in the period 1975 - 1994 were included in the study. Data was collected using the morbidity certificates of the Hospital de Reabilitação de Anomalias Craniofaciais (Craniofacial Abnormalities Rehabilitation Hospital), Ministry of Health data (Datasus), and Fundação Instituto Brasileiro de Geografia e Estatística (Brazilian Census Bureau). RESULTS/CONCLUSIONS: There were 16,853 new cases of oral clefts, with a total prevalence of 0.19 per 1,000 births, and there was an increased prevalence every five years. The highest prevalence were observed in the Midwest, southeast, and south regions. As for the studied categories, cleft lip (or the cleft of lip and palate) was seen in 74% of the cases and isolated cleft palate was seen in 26% of them.

Brazil↗
PubMed1994

[Cleft lip and palate: case-control study].

This study relates to a case-control analysis for the purpose of verifying the association between oral clefts and possible risk factors. The analysed variables were: place of mother's residence (urban/rural), pollution, parental diseases, mother's diseases during the first four months of pregnancy, intake of drugs related to this period, heredity, smoking habits, alcohol consumption and X-ray examinations during pregnancy or X-ray examinations prior to pregnancy. There were 450 cases of clefts of whom 354 had a cleft lip with or without cleft palate and 96 had a cleft palate. The relative risk (RR) for each variable by was estimated points and at a 95% of confidence interval and multivariate analysis was applied. As regards cleft lip with or without cleft palate, the risk factors are heredity (RR = 4.96), epilepsy in the mother (RR = 2.39) and the intake of drugs such as anti-inflammatory substance in the first four months of pregnancy (RR = 2.59). Related to cleft palate, the risk factors are heredity (RR = 2.82) and pollution (RR = 2.58).

Brazil↗
PubMed1994

P-A cephalometric analysis of nonoperated adult cleft lip and palate.

P-A cephalometric analysis was performed on the craniofacial morphology in 88 Brazilian men with nonoperated and operated cleft lip and palate. For the comparative study, these subjects were divided into the following four groups: (1) 31 nonoperated unilateral cleft lip and palate (UCLP), (2) 24 nonoperated bilateral cleft lip and palate (BCLP), (3) 16 operated UCLP, (4) 17 operated BCLP. Thirty Brazilian men without cleft lip and palate were used as control subjects. In comparison with the control subjects, nonoperated BCLP and UCLP showed remarkable facial deformity characterized by increased width of various facial parts. Facial morphology of surgically treated BCLP and UCLP, however, was very similar to that of noncleft subjects, apart from the immediate cleft region. There was no remarkable difference in the facial morphology between nonoperated BCLP and UCLP, except for the cleft width and the deviation of nasal septum base, while the only significant difference between operated BCLP and UCLP was in the cleft width.

Adolescent↗
PubMed1991

Ectrodactyly, cleft lip/palate syndrome.

We report on a Brazilian boy with ectrodactyly, cleft lip/palate, and abnormal pinnae. The clinical aspects involving this patient strongly suggest those reported by Lewis and Pashayan in 1981. Clinical and genetic aspects are discussed.

Child↗
PubMed1991

Assessment of the nasopharyngeal area by cephalometry in cases of cleft lip and palate.

The nasopharyngeal area in 149 patients with cleft lip and palate and 157 normal individuals was evaluated by cephalometric radiography. The patients were male and female Caucasians, ranging in age from 12 to 16 years. Linear cephalometric parameters: (Ptm'-Sl; Ptm'-IPPF; IPPF-I, I-Ptm'), ANS angle and nasopharyngeal area were utilized. From comparative analysis of nasopharyngeal area in the cleft and the control groups, the following conclusions were made: 1) The nasopharyngeal area was smaller in the cleft group. 2) There was no correlation between ANS angle and nasopharyngeal area in either group.

Adolescent↗
PubMed1990

Rapp-Hodgkin syndrome: report of a Brazilian family.

We report on a Brazilian family with 11 affected patients through 4 generations presenting the Rapp-Hodgkin syndrome. The main clinical findings in different patients ranged from isolated trichodysplasia (sparse, brittle, and dry hair) to ectodermal dysplasia (1-2-3-4), cleft palate, tear duct anomaly, and minor limb anomalies. Clinical and genetic aspects concerning this condition are discussed.

Abnormalities, Multiple↗
PubMedDate not supplied

[Analysis of the nasal area in unilateral cleft lip and palate, by means of cephalometric teleradiography].

In a cross-sectional study with 149 patients with complete unilateral cleft lip and palate and 157 non-cleft patients aged from twelve to sixteen, Caucasian males and females were evaluated through lateral cephalometric radiographs of the nasal area. One angular (SNA), 4 linear (S-N; N-P'; P'-Ptm'; Ptm'S) and medial cephalometric measurements of the nasal area were used. In a comparative analysis of the nasal area in cleft lip and palate and control groups one can conclude that: 1. The nasal area in cleft patients is smaller than in non-cleft patients. 2. There is no correlation between the angle (SNA) and the nasal area for the cleft patients and control patients.

Adolescent↗
PubMedDate not supplied

[Facial bone changes in Virchowian Hansen's disease].

Aiming to verify the occurrence of alterations in certain skeletal structures in lepromatous face, 70 patients from the "Hospital Lauro de Souza Lima", were clinically and radiographically analysed through a longitudinal study with a 3 years interval: their average age was of 45.41 years and 48.41 years respectively for the first and second examinations.

Alveolar Process↗
PubMedDate not supplied

[New criteria for the characterization of facies leprosa].

Facies leprosa was characterized by a combination of nasal change and resorption of nasal bone, anterior nasal spine, supra-incisive alveolar region and anterior alveolar process of the maxilae, associated with the loss of upper incisors teeth, according to the criteria of radiographic interpretation.

Bone Resorption↗