Biomedical subjects

J A Hidalgo

Publications and source records attributed to J A Hidalgo.

5 recordsLinked to original sources

PubMed2000

An overview of HIV infection and AIDS: etiology, pathogenesis, diagnosis, epidemiology, and occupational exposure.

Thanks to a worldwide collaborative effort among health care providers, academia, governments, and industry, our knowledge base about infection caused by the human immunodeficiency virus (HIV) has expanded exponentially. During the past 2 decades, we have learned about its pathogenesis, virology, immunology, epidemiology and treatment. In the developed world, the approach to persons with HIV disease has evolved from palliative disease care to use of a chronic disease model, where survival is measured by decades, not months or years. More and more, clinical decision-making for HIV-infected patients is driven by comorbidities, including cardiothoracic disease. Thus, our clinically stable HIV population is increasingly accessing those health care services required by any maturing population, including the usual services of cardiothoracic surgeons. In this article, we review the basic facts of HIV disease, with an emphasis on occupational risks and infection control procedures.

AIDS-Related Opportunistic Infections↗

PubMed2000

Fungal endophthalmitis diagnosis by detection of Candida albicans DNA in intraocular fluid by use of a species-specific polymerase chain reaction assay.

Candida endophthalmitis is a serious infection secondary to hematogenous dissemination or direct inoculation of the organisms following trauma or eye surgery. The diagnosis is based on the characteristic findings in the infected eye and on culture of vitreous samples. Unfortunately, the yield of vitreous cultures is limited. The use of a Candida albicans species-specific polymerase chain reaction (PCR) assay in the diagnosis of Candida endophthalmitis is reported herein. Four patients with suspected fungal endophthalmitis underwent vitrectomy for diagnostic and therapeutic purposes. In 2 of the 4, vitreous cultures were negative. However, characteristic PCR products were generated in all 4 patient specimens, enabling the rapid diagnosis of Candida endophthalmitis in all 4. Clinical response was observed in all cases. These results demonstrate the utility of PCR-mediated detection of C. albicans in vitreous samples.

Adult↗

PubMed1993

Can visual perception be used to estimate body part angles?

For two decades, observational methods have been used to measure postural loads in industry. These methods depend on the analyst's judgment to characterize correctly the working postures. The errors associated with estimating the body part's angular deviation from the neutral position are not known. Recently, videotaping of a work situation, followed by examination of the tape to assess postural position has become more commonly practised. This study was conducted to determine the error which accompanies the judging (without tools) of postural angles. In the present study, a method was used whereby 20 subjects were asked to report the perceived angles which closely matched the actual shoulder flexion angle displayed on the TV screen. The results showed no significant differences among the three angular ranges ('low', 1-60 degrees; 'medium', 61-120 degrees; and 'high', 121-180 degrees) of shoulder flexion, in terms of algebraic and absolute errors. Subjects tended to slightly overestimate the true angle in the low range and to slightly underestimate the true angle in the medium and high angle ranges. This study suggests that visual perception can be used to estimate shoulder flexion angles displayed on a VDT.

Adult↗

PubMed1992

Occupational biomechanics of the neck: a review and recommendations.

Musculoskeletal disorders of the neck are becoming a major concern in industry. Several studies reported the association of neck pain, discomfort, and symptoms with different occupations in industry. Thus, the main objective of this study is to review and evaluate biomechanical techniques used in analyzing the occupational factors leading to neck pain and disorders. Recommendations for future research are also discussed.

Biomechanical Phenomena↗

PubMedDate not supplied

Use of sargramostim (rh-GM-CSF) as adjunctive treatment of fluconazole-refractory oropharyngeal candidiasis in patients with AIDS: a pilot study.

PURPOSE: Fluconazole-refractory mucosal candidiasis is a significant problem in patients with advanced HIV disease. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is postulated to activate neutrophils, enhance phagocytosis, and increase intracellular killing of Candida species. The aim of this study was to evaluate the use of sargramostim (rh-GM-CSF) in combination with fluconazole for refractory mucosal candidiasis in patients with AIDS. METHOD: Patients with mycologically confirmed fluconazole-refractory oropharyngeal candidiasis who failed fluconazole 400 mg/day for a minimum of 7 days were enrolled, continued on fluconazole (400 mg/day), and received sargramostim 2.5 microg/kg/day for a minimum of 2 weeks. Patients were evaluated for clinical signs and symptoms of oropharyngeal candidiasis, and quantitative fungal cultures were taken at baseline and the end of weeks 1 and 2 of therapy. RESULTS: Eleven patients were entered, 3 out of 11 patients were cured, 6 were unchanged, and 2 were worse at the 2-week evaluation. Mycological response was seen in 7 out of 11 patients. CONCLUSION: In this small pilot study, sargramostim appears to exert a beneficial effect on the mucosal mycoflora and may be a possible alternative as adjunctive therapy in the management of fluconazole-refractory mucosal candidiasis in advanced HIV-positive patients.

AIDS-Related Opportunistic Infections↗