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Biomedical subjects

J A Jahre

Publications and source records attributed to J A Jahre.

13 recordsLinked to original sources
PubMed2000

Osteogenesis imperfecta with extreme bone fragility.

Osteogenesis Imperfecta ordinarily leads to an early death. Survival to age 30 is unusual. In this case the patient achieved some pleasure in life, was reported to be of normal intellectual capacity, and proved capable of great skill in certain crafts. He truly lived his life and his last years were made possible by skills of his home health care team, the devotion of his mother, and his own determination, humor, defiance, and toughness of character.

Adult↗
PubMed1991

Policy for managing a community infectious disease outbreak.

OBJECTIVE: To identify guidelines for the management of an infectious disease emergency. SETTING: In February 1990, the discovery of hepatitis A in three foodhandlers prompted city and state health officials to offer mass immunization to residents of several counties in eastern Pennsylvania. In an attempt to facilitate the immunization effort, local hospitals were asked to establish and staff clinics to supplement the efforts of the health bureaus. RESULTS: Over a four-week period, combined efforts resulted in approximately 10,000 people receiving immunization with immune serum globulin (IgG). CONCLUSIONS: This was one of several infectious disease emergencies the community has faced in the recent past. Recognizing that future incidents of this nature are likely to occur, one 435-bed community teaching hospital devised an infectious disease emergency policy that allows for rapid deployment of personnel and services in the event of an infectious disease outbreak.

Clinical Protocols↗
PubMed1986

Isolation of Corynebacterium aquaticum from spinal fluid of an infant with meningitis.

A 4-week-old female was hospitalized because of vomiting, irritability, and nuchal rigidity. A spinal fluid culture yielded Corynebacterium aquaticum. The diagnosis of C. aquaticum meningitis in this infant was supported by the following cerebrospinal fluid findings: Gram stain, elevated protein, hypoglycorrhachia, positive C-reactive protein, and polymorphonuclear leukocytosis. Antigen studies for common bacterial causes of meningitis were negative. C. aquaticum is a rare cause of human disease and may be initially confused with Listeria monocytogenes, which is a more common gram-positive, motile rod associated with meningitis in infants.

Corynebacterium↗
PubMed1980

Role of a cefoxitin-inducible beta-lactamase in a case of breakthrough bacteremia.

Development of resistance during therapy with cefamandole contributes to treatment failure. A simple cefoxitin disk test was recently described which detects a cefamandole-active inducible beta-lactamase not otherwise detectable with cefamandole as the inducer. A case of breakthrough Enterobacter bacteremia due to selection of a resistant subpopulation is reported in an immunocompromised patient. The use of this simple disk test in selected clinical cases is advocated.

Adult↗
PubMed1979

Clinical evaluation of netilmicin therapy in serious infections.

Netilmicin, a new semisynthetic aminoglycoside, was evaluated in the therapy of 33 episodes of infection in 30 patients. Eighteen patients had documented bacteremia. Infection sites included pulmonary, urinary tract and soft tissue areas. A complete bacteriologic and clinical cure rate of 85 per cent was achieved. No treatment failures occurred in the bacteremic group. Although netilmicin is less effective than gentamicin in vitro against Pseudomonas, it was clinically and bacteriologically effective. Netilmicin bacteriologic cures occurred in patients whose organisms were inhibited by 6.2 microgram/ml or less of netilmicin. Despite a uniform dosing protocol, a wide range of netilmicin serum levels was obtained. Adverse effects were limited to one case of transient nephrotoxicity and one Candida urinary suprainfection. Netilmicin appears to be an effective, safe agent for the therapy of serious infections.

Adult↗
PubMed1979

Mezlocillin in the therapy of serious infections.

Mezlocillin, a new semisynthetic penicillin chemically related to ampicillin which is more active than carbenicillin against Ps. aeruginosa, B. fragilis and Strep. faecalis and which inhibits many Klebsiella, was evaluated in the therapy of 34 episodes of infection in 26 patients. Infection sites included pulmonary, urinary tract and tissue infections, including peritonitis. Seven patients had bacteremia. Clinical cures were achieved in 83 per cent and bacteria cures in 76 per cent of infections. Cure was achieved with mezlocillin in patients with infections caused by carbenicillin-resistant species. Adverse effects of therapy were minimal, one rash and one episode of reversible neutropenia. Serum and body flevels of susceptible organisms.uid levels were easily maintained above the inhibitory levels of susceptible organisms. Mezlocillin was a safe, well tolerated and effective antibiotic in the treatment of infections due to susceptible organisms.

Adolescent↗
PubMed1978

Kinetics of netilmicin and gentamicin.

The kinetic parameters of netilmicin were studied in normal human subjects. In the intravenous study a steady-state was obtained in 4 subjects by the constant infusion of 2 mg/kg of netilmicin during the first hour followed by 0.5 mg/kg/hr for each of three successive hours. Creatinine clearance was greater than the simultaneous serum and renal clearance of netilmicin. In the intramuscular study 6 subjects received a single injection of 1 mg/kg of netilmicin followed by the same dose of gentamicin 1 wk later. A mean peak serum levels of 3.9 microgram/ml was found for both antibiotics, but the mean serum half-life of netilmicin was shorter than that of gentamicin. Doubling the intramuscular dose of netilmicin approximately doubled the peak serum level. In both studies 75% to 90% of the netilmicin was recovered in the urine within the first 24 hr. Netilmicin appears to be primarily excreted by glomerular filtration. The apparent volume of distribution was similar to that reported for other related aminoglycosides. Netilmicin and gentamicin have similar kinetic parameters. There were wide individual differences among normal subjects with both drugs.

Female↗