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Biomedical subjects

J A Jerome

Publications and source records attributed to J A Jerome.

4 recordsLinked to original sources
PubMed1991

A new robust index for measuring isokinetic trunk flexion and extension. Outcome from a regional study.

The purpose of this study was 1) to provide normative data for isokinetic trunk strength as measured by peak torque, best work repetition, and a new composite variable, "muscle performance index"; and 2) to examine the effects of protocol velocity, subject age, gender, height, and weight on these measurements. A significant decrease in peak torque of extension for females (P less than 0.0001) was seen as protocol velocity increased, but no differences were seen in males. A statistically significant amount (0.5-0.7) of the variance in isokinetic measurements was explained by subject age, height, and weight. Multivariant analysis of covariance showed the effects of these variances to be significant on all measurements except for the muscle performance index, which was unaffected by protocol velocity and remained stable without adjustments for subject age, weight, or height.

Adult↗
PubMed1987

Effects of desipramine on irritable bowel syndrome compared with atropine and placebo.

Antidepressant treatment trials of irritable bowel syndrome (IBS) have suggested beneficial effects. Twenty-eight patients with the disorder (9 constipation-predominant, 19 diarrhea-predominant) completed a double-blind crossover study using desipramine, atropine, and placebo in random sequence. A four-week observation period preceded three six-week test periods. Bowel habits, abdominal distress, and affect were reported daily and in biweekly evaluations. Psychological assessments and rectosigmoid contractile studies were done in each period. Stool frequency, diarrhea, abdominal pain, depression, and slow contractions decreased significantly more in diarrhea-predominant patients during desipramine compared with placebo and atropine treatments. Diarrhea-prone patients' depression scores fell more in all periods than constipation-prone patients. Fifteen patients (13 diarrhea-predominant) improved globally during desipramine, five during placebo and six during atropine treatments. Desipramine may be helpful in treating IBS, perhaps through antidepressant and antimuscarinic effects.

Adult↗
PubMed1985

Antifungal properties of 3-n-alkyn-1-ols and synergism with 2-n-alkyn-1-ols and ketoconazole.

Twelve 3-n-alkyn-1-ols (C4-C12, C14, C16, and C18) were tested against Aspergillus oryzae, Aspergillus niger, Trichoderma viride, and Myrothecium verrucaria in Sabouraud dextrose agar at pH 5.6 and 7.0. Toxicity to Candida albicans, Candida tropicalis, Trichophyton mentagrophytes, and Mucor mucedo was determined in the same medium at pH 5.6 and 7.0 in the absence and presence of 10% beef serum. Fungitoxicity was strongly influenced by chain length, slightly by pH of the medium, and significantly but not strongly by the presence of beef serum. 3-n-Decyn-1-ol, 3-n-undecyn-1-ol, and 3-n-dodecyn-1-ol were the most active members of the series. Synergism toward C. albicans and C. tropicalis was observed between 3-n-undecyn-1-ol and ketoconazole, and a mixture of 3-n-undecyn-1-ol, 2-n-undecyn-1-ol, and ketoconazole in Sabouraud dextrose agar at pH 7.0 in the presence of 10% human serum.

Alcohols↗