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J A LITTLE

Publications and source records attributed to J A LITTLE.

At least 19 recordsLinked to original sources
PubMed1964

A COMPARISON OF THE ORAL AND INTRAVENOUS GLUCOSE TOLERANCE TESTS IN NON-DIABETIC, POSSIBLE DIABETIC AND DIABETIC SUBJECTS.

Results of standard three-hour oral glucose tolerance tests (OGTT) and intravenous glucose tolerance tests (IVGTT), performed on the same subjects, were compared in an attempt to determine their value in the diagnosis of borderline diabetes. A total of 83 such tests were carried out on 81 subjects. Applying the U.S. Public Health Service point count method to the results of the OGTT test, there were 38 normals, 23 possible diabetics and 22 diabetics. A constant (K) was calculated from the glucose disappearance rate in the IVGTT curves.K disagreed with the OGTT classification to a significant extent, especially in the possible diabetic and non-diabetic groups. Also, the correlation coefficients between K and the OGTT values were not impressive. This does not mean that one test is superior to the other, only that the accuracy of either test in diagnosing early diabetes is doubtful.Technically, the IVGTT was more difficult and time-consuming, and six of the 81 subjects suffered from thrombophlebitis at the site of glucose injection.

Blood Glucose↗
PubMed1964

PSYCHOLOGICAL TIME.

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Biological Clocks↗
PubMed1964

STUDIES OF MALE SURVIVORS OF MYOCARDIAL INFARCTION DUE TO "ESSENTIAL" ATHEROSCLEROSIS. 3. CORNEAL ARCUS: INCIDENCE AND RELATION TO SERUM LIPIDS AND LIPOPROTEINS.

Corneal arcus and serum lipids were studied in 121 men, aged 30 to 80, with atherosclerotic coronary heart disease (CHD), and in healthy controls. In both groups the incidence of arcus increased from 55% in the fifth decade to 90% in the eighth. Under 40, arcus was a significant differentiating sign, being present in 11 of the 25 coronary patients and in none of the controls. In both groups, to age 60, the incidence of arcus correlated with serum cholesterol and phospholipid but not with standard Sf 0-400 lipoprotein fractions. In the CHD group there was significant elevation of the serum lipids. Since arcus is itself a fatty infiltration of the eye, these findings support the importance of serum lipids in atherogenesis. Clinically, corneal arcus in a male under 40 may be a clue to hyperlipidemia and a propensity to CHD.

Arcus Senilis↗
PubMed1963

STUDIES OF MALE SURVIVORS OF MYOCARDIAL INFARCTION DUE TO "ESSENTIAL" ATHEROSCLEROSIS.

Serum lipids (total, ester and free cholesterol, phospholipid and standard S(f) 0-12, 12-20, 20-100 and 100-400 lipoproteins) were determined in 102 men, ages 30-70, with atherosclerotic coronary heart disease (C.H.D.), free of hypertension, diabetes or other complicating variables. All the lipid fractions had a lognormal distribution. All were significantly higher than in the controls up to the seventh decade. An explanation for the declining serum lipid levels with age was found. Contrary to previous reports, there was no abnormality in the relation of various lipid fractions to one another in C.H.D. A spurious correlation between C/P ratio and total cholesterol was found in both groups. In separating coronary and control subjects, cholesterol and 0-12 lipoproteins were the most reliable criteria and were equal in this respect. The misclassification rises from 20% in the fourth to 33% in the seventh decade. C/P ratio offered no improvement. The triglyceride-containing 100-400 lipoprotein was an inferior discriminator. Employing all the lipid fractions, discriminant analysis provided a minimum 12% misclassification in the fourth decade. There was no demonstrable relationship of cholesterol to body measurements, physical activity or family history of C.H.D.

Atherosclerosis↗