J A Magbagbeola | PubMed Health

PubMed1988

Failure of lidocaine to modify suxamethonium induced biochemical changes.

Twenty patients were studied in a prospective double-blind randomized trial to determine the effects of intravenous lidocaine pretreatment on suxamethonium induced biochemical changes. Lidocaine 1 mg. kg-1 failed to attenuate changes in serum potassium, significantly decreased serum calcium, and prolonged duration of suxamethonium blockade. There were no significant changes in plasmacholinesterase activity or other biochemical parameters. It is concluded that pretreatment with 1 mg. kg-1 lidocaine failed to attenuate suxamethonium induced biochemical changes.

Adult↗

PubMed1987

Effect of pre-treatment with lysine acetyl salicylate on suxamethonium-induced myalgia.

The hypothesis that prostaglandin inhibitors might reduce the incidence and severity of suxamethonium-induced myalgia was investigated using lysine acetyl salicylate (LAS) 13 mg kg-1 i.v. 3 min before the administration of suxamethonium in 20 patients. A comparison was made with atracurium 0.09 mg kg-1 (and placebo) in a double-blind prospective randomized trial. LAS and atracurium were effective in reducing the incidence and severity of postsuxamethonium myalgia and the increases in serum potassium concentration. There were no appreciable changes in serum calcium, sodium, chloride, phosphate, magnesium, creatinine, creatine phosphokinase concentrations or plasmacholinesterase activity. Atracurium caused a delay in the onset of action and a decrease in the intensity of suxamethonium-induced neuromuscular block. It is concluded that LAS pretreatment might have a place in suitable patients in the prevention of suxamethonium-induced myalgia and increases in serum potassium concentration.

Adult↗

PubMed1982

Metabolic response to anaesthesia and prostatectomy in Nigerians. Changes in plasma cortisol and blood sugar.

In ten Nigerian patients undergoing prostatectomy, plasma cortisol was slightly decreased by pre-medication with atropine and pethidine and during general anaesthesia without surgery. This decrease was not statistically significant. There was, however, a statistically significant increase in plasma cortisol after 1 h of surgery and also in the post-operative period. The blood sugar was elevated by pre-medication and surgery though the rise was not significant. There was a significant rise of blood sugar after 30 min of surgery and in the post-operative period. These findings in general are similar to those observed in ten Nigerian patients undergoing upper abdominal surgery, although the rise in plasma cortisol was higher following upper abdominal surgery, and the rise in blood sugar higher following lower abdominal surgery.

Anesthesia, General↗

PubMed1982

Metabolic response to anaesthesia and lower abdominal surgery in Nigerians. Changes in plasma cortisol and blood sugar.

In ten Nigerian patients undergoing prostatectomy, plasma cortisol was slightly decreased by pre-medication with atropine and pethidine and during general anaesthesia without surgery. This decrease was not statistically significant. There was, however, a statistically significant increase in plasma cortisol after 1 h of surgery and also in the post-operative period. The blood sugar was elevated by pre-medication and surgery though the rise was not significant. There was a significant rise of blood sugar after 30 min of surgery and in the post-operative period. These findings in general are similar to those observed in ten Nigerian patients undergoing upper abdominal surgery, although the rise in plasma cortisol was higher following upper abdominal surgery, and the rise in blood sugar higher following lower abdominal surgery.

Abdomen↗

PubMed1979

Plasma potassium, sodium and blood sugar following etomidate and suxamethonium.

Changes in plasma potassium, sodium and blood sugar were studied in Nigerian patients following induction of anaesthesia with etomidate and suxamethonium. Healthy patients presenting for elective surgery as well as psychiatric patients presenting for electroconvulsive therapy were studied. Plasma potasium was essentially unaffected by etomidate administration, but rose significantly when suxamethonium was given. This rise was higher than that observed with thiopentone and suxamethonium in a previous study on a similar group of Nigerians. Blood sugar was not significantly increased by the administration of etomidate but rose significantly after suxamethonium was given. This hyperglycaemic response was greater than when thiopentone was used as the induction agent. Administration of ECT was associated with a further increase in blood sugar. It is concluded that thiopentone is preferable to etomidate in situations where increases in plasma potassium and blood sugar are undesirable following administration of suxamethonium.

Adult↗

PubMed1975