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Biomedical subjects

J A Malone

Publications and source records attributed to J A Malone.

11 recordsLinked to original sources
PubMed1986

Removal of lipopolysaccharide from acellular Bordetella pertussis vaccine by detergent treatment.

Protective antigen was extracted from Bordetella pertussis cells with 1.0 M NaCl and precipitated with ammonium sulfate, 20-40% saturation (designated fraction 15A-1B). The protective antigen was purified further by detergent (Emulphogene BC720) treatment and adsorption to aluminum hydroxide gel (designated fraction 15A-108A). Compared with B. pertussis vaccine and fraction 15A-1B, fraction 15A-108A retained protective activity as assessed by the mouse protection test, but had reduced protein and markedly reduced endotoxin content. Fraction 15A-108A also had reduced leukocytosis-promoting, histamine sensitizing splenomegaly-inducing, and adjuvant activities. Emulphogene treatment provided a relatively simple method for removing endotoxin from a potential acellular B. pertussis vaccine.

Adjuvants, Immunologic↗
PubMedDate not supplied

The DSM-III-R versus nursing diagnosis: a dilemma in interdisciplinary practice.

Given the dynamics of the multidisciplinary team and the infancy of nursing diagnoses specific to psychiatric nursing, most nurses prefer using the DSM-III-R to document practice or do not see nursing diagnoses as relevant. The DSM-III-R, first published as the Diagnostic and Statistical Manual in 1952, is specific to the medical care of individuals and oriented toward "cure"; nursing diagnoses, initiated in 1973, are applicable to individuals, families, and groups and address human response to actual or potential health problems. The similarities of these two diagnostic systems include being a guide to practice, evolving as works of political compromise with international import, and serving as communication systems. However, without understanding the differences or similarities between these linguistic systems, nurses opting to use only the DSM-III-R do not contribute to understanding phenomena germane to psychiatric nursing, perpetuate the invisibility of nursing to patient care, and invite turf battles with other professions.

Humans↗
PubMedDate not supplied

Family adaptation: adult sons with long-term physical or mental illnesses.

A descriptive study of 62 family members with an outpatient adult son with a long-term physical (8 families) or mental (3 families) illness using multiple methods and multiple family members' perspectives. Family members completed FILE, FIRM, FAM-III. FACESIII, the Progress Evaluation Scale, and the Nottingham Health Profile. Single-item indicators were based on Rolland's (1988) psychosocial typology of illness, Mishel's (1988) components of uncertainty of illness, and selected demographics. On most of the instruments and their subscales, there were few statistical differences. Family members often did not report the same diagnosis. Based on the qualitative data, families coped by "just working with it" or "trying to step back."

Adaptation, Psychological↗
PubMedDate not supplied

Computers in nursing practice. A comparison of the attitudes of nurses and nursing students.

This study was undertaken to compare the attitudes of nurses and nursing students toward computer use in nursing practice and to clarify factors that influence these attitudes. Three factors within the student sample were examined: changes over time, prior experience with computers, and attitudes toward technology in general. Second, the attitudes of the nursing students were compared with those of a sample of practicing nurses. Finally, the multidimensional structure of Stronge's attitude scale was analyzed. A total of 353 sophomore nursing students and 358 staff nurses participated in the study. The analysis produced a refined 17-item attitude scale composed of three identifiable subscales: computers and patient care, computers and personal security, and general attitude. It was found that students had less experience with computers than the investigators had anticipated, and there was little change over three successive cohorts of students. However, in general, students' attitudes toward computer use in nursing were positive, and the more computer experience students had, the more positive their attitudes. The attitudes of the practicing nurses also were generally positive, but differences between students and nurses were observed.

Attitude to Computers↗