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Biomedical subjects

J A McCrary

Publications and source records attributed to J A McCrary.

At least 37 records · Page 2Linked to original sources

'Cholesteatoma' of the orbit.

'Cholesteatoma' of the orbit is a variant of pseudotumor histologically characterized by masses of cholesterol crystals. We propose the term "epidermoid or true cholesteatoma" for lesions containing epithelial elements and refer to those nonepithelium-containing pseudotumors as "cholesterol granulomas." Important clinical features distinguish between epidermoid cholesteatomas and cholesterol granulomas of the orbit and justify a separation of these two pathologic entities.

Adolescent↗

Chiasmal optic neuritis.

Two patients exhibiting bitemporal hemianopia due to chiasmal optic neuritis with pathological confirmation of noncompressive lesions are presented; the first due to a chronic, idiopathic demyelinating process, and the second a result of ethchlorvynol (Placidyl) toxicity. The literature regarding chiasmal optic neuritis is reviewed, and a discussion of other noncompressive causes of bitemporal hemianopia is presented.

Adult↗

Automated perimetry in a neuro-ophthalmologic practice.

Visual field examinations were performed with both the Fieldmaster Automated Perimeter and the Goldmann kinetic perimeter on 60 patients, aged 10 to 70 years (118 eyes) referred for neuro-ophthalmologic evaluation. Results suggest that the Fieldmaster perimeter is almost as sensitive as the Goldmann perimeter in identifying abnormal visual fields (99.2%). False-positive results were noted in only two cases (1.6%). Fieldmaster perimetry demonstrated certain advantages over Goldmann perimetry in easily fatigued, inattentive, or uncooperative patients. Recent technological advances in automated perimetry resulting in greater sensitivity and reproducibility of results now offer a viable alternative to Goldmann perimetry.

Adolescent↗

Voluntary nystagmus masquerading as Tullio's Phenomenon.

Nystagmoid eye movements elicited by humming loudly was initially misdiagnosed as Tullio's phenomenon (abnormal acoustical stimulation of the vestibular apparatus owing to labyrinthine fistula). Further workup lead to a final diagnosis of a form of voluntary nystagmus characterized in some reports as "hysterical mystagmus". Some of the characteristics of this example of voluntary nystagmus differed from generally accepted descriptions.

Adult↗

Multiple cranial nerve palsies in late metastasis of midline malignant reticulosis.

A 12-year-old man had a sudden onset of multiple cranial nerve palsies after treatment for a necrotizing lesion of the soft palate two years previously. It was thought that neurologic signs were secondary to extension of the local disease and radiation therapy to the base of the brain was begun. The patient died shortly thereafter. A diffuse atypical histiocytic lymphoma involving multiple cranial nerves, lumbosacral nerves, orbital muscles, and other organs was found on autopsy. Initial nasopharyngeal biopsy and autopsy findings were compatible with midline malignant reticulosis, a malignant lesion of the upper airway sometimes associated with metastasis. Our case is the first reported autopsy-documented case, to the best of our knowledge, of metastatic involvement of the cranial nerves in midline malignant reticulosis.

Adult↗

Pituitary apoplexy following chlorpromazine stimulation.

Chlorpromazine is frequently administered to patients with hyperprolactinemia to stimulate an increase in the serum levels of prolactin. A patient with a prolactin secreting adenoma is described in whom pituitary apoplexy developed in association with a hypotensive episode following the administration of 25 mg of chlorpromazine. Prolactin levels fell from more than 2,000 ng/ml to 340 ng/ml following infarction of the pituitary tumor. Pituitary apoplexy should be considered as a rare complication of chlorpromazine stimulation in a patient with a pituitary tumor.

Adenoma, Chromophobe↗

Autosomal recessive retinitis pigmentosa and Coats disease: a presumed familial incidence.

Three of four siblings of normal parents had a combination of Coats disease and retinitis pigmentosa bilaterally. Our report of their respective cases is, to our knowledge, the first report of a familial incidence of the combination of the two diseases in an individual and supports the implication that Coats disease may be a genetic abnormality. The pathological process was essentially the same in all three patients, although it occurred differently in one of the three siblings and gave rise to an altered functional and clinical picture. The similarities may indicate that the convenient categories of "tapeto-retinal degenerations" are clinical variations of the same genetic abnormality.

Adolescent↗

Diagnosis of superficial temporal arteritis.

Giant cell arteritis is an insidious disease which is often first suspected and diagnosed by the ophthalmologist. Because of the high incidence of serious ophthalmologic complications associated with the disease, the ophthalmologist has more than passing interest in establishing the diagnosis. Biopsy confirmation has become increasingly important as more clinical syndromes associated with giant cell arteritis are recognized. The purpose of this paper is to describe a technique for biopsy of the superficial temporal artery which insures obtaining an adequate specimen for histologic examination.

Biopsy↗

Computed tomography and magnetic resonance imaging in the diagnosis of inflammatory disease of the optic nerve.

Enlargement of the optic nerve and chiasm as demonstrated by high-resolution CT scanning or magnetic resonance imaging is often assumed to indicate tumor. However, this is not always true. The mode of clinical presentation of the disease process must be correctly applied to the interpretation of the radiographic studies. In the case illustrated here, neuro-ophthalmologic evaluation prevented an unnecessary biopsy in a patient whose presentation was atypical for anterior visual pathway glioma and whose clinical course was otherwise compatible with optic neuritis.

Child↗