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Biomedical subjects

J A Mead

Publications and source records attributed to J A Mead.

At least 19 recordsLinked to original sources
PubMed1976

Renal stones and urinary infection: a study of antibiotic treatment.

Twenty-two patients in whom renal calculi and urinary infection were closely associated were studied over two to five years. Four patients had previously had stones surgically removed, and five underwent pyelolithotomy during the course of the study. Urinary infection was treated with an appropriate antibacterial agent, and treatment was followed by long-term prophylaxis, usually with cotrimoxazole. A sterile urine was maintained for long periods in all these patients. In four patients, however, apparent stone growth occurred while the urine was sterile. On entering the study 21 of the 22 patients complained of symptoms. After treatment 19 of the 20 patients who were still attending were symptom-free. Six of the 22 patients entered the study with raised levels of serum creatinine; levels fell in four and remained raised in two. This antibacterial regimen, either alone or after surgery, will usually relieve symptoms and may prevent deterioration of renal function.

Adult↗
PubMed1976

Pharmacology of antitumor agents from higher plants.

Some pharmacologic properties of nine antitumor agents from higher plants are described. The agents are vincristine, vinblastine the epiodophyllotoxin derivatives VM-26 and VP-16-213, maytansine, bruceantin, thalicarpine, camptothecin, and lapachol. When sufficient information is available, the agents are discussed with regard to their antitumor activity, mechanism of action, pharmacologic disposition, structure-activity relationships, and toxicity.

Animals↗
PubMed1976

Comparative ultrastructure of submaxillary salivary glands from mice treated with cytosine arabinoside, cyclocytidine, and anhydro-ara-5-fluorocytidine.

The effects of cytosine arabinoside (ara-C), cyclocytidine (cyclo-C), and anhydro-ara-5-fluorocytidine (AAFC) on the ultrastructure of the serous and mucous cells of the submaxillary salivary glands were evaluated in normal BDF1 mice. Rapid loss of zymogen granules from serous cells and a discharge of mucous cell contents were observed within the first hour after administration of a single iv dose of cyclo-C. Serous cells were essentially devoid of granules (1-3 mum) within 3 hours; regranulation observed initially at 6 hours produced a population of microgranules (approximately 0.8 mum) by 24 hours; most serous cells contained a reduced complement of small granules through 96 hours after cyclo-C. Mucous cells recovered secretory content within 3-6 hours after drug administration. Neither ara-C nor AAFC produced zymogen-granule or mucous discharge or other cytopathologic effects in the murine submaxillary salivary glands. Thus, it can be postulated that cyclo-C itself is the secretogogue. The ultrastructural changes observed in this study provide a cytopathologic correlate of the salivary gland dysfunctions reported to follow the administration of cyclo-C to man.

Ancitabine↗