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Biomedical subjects

J A Molinari

Publications and source records attributed to J A Molinari.

At least 127 records · Page 7Linked to original sources
PubMed1974

Investigation of secretory immunoglobulins in saliva from germfree mice.

We investigated the effect of oral immunization on the serum and salivary immunoglobulin levels in axenic and conventional NIH mice. Specific antibacterial and antifungal antibodies were measured by passive hemagglutination, and differences in the immunoglobulin classes were measured by radial immunodiffusion. After an oral immunization regimen with either intact Escherichia coli or Candida albicans, a significant increase in specific antibody above the base-line reciprocal titer of 32 was observed in conventional mouse saliva. Saliva from axenic mice immunized with the formalized microorganisms yielded reciprocal antibody titers of 256, as compared with an absence of specific antibodies in control animals. Assay of the sera of both groups of immunized mice revealed no increase in antibody levels specific for E. coli lipopolysaccharide or Candidin.

Animals↗
PubMedDate not supplied

Condyloma acuminatum in the oral cavity: four cases and a review.

The number of reported cases of condyloma acuminatum has increased rapidly in recent years. While the viral etiology of these lesions has been established, differentiation from other papular growths is often difficult. Reports of condyloma acuminatum lesions in the oral cavity are appearing more frequently, although they still are sparse. Four cases of oral condyloma are described, and the English-language literature on other such cases is reviewed. Presumably, as the incidence of this type of infection continues to increase, oral condylomata will become a commoner diagnosis. Physicians and dentists should be aware of the necessity of recognizing wart-like eruptions in and around the oral cavity.

Adult↗
PubMedDate not supplied

Histological response to ivory implanted in rabbit mandibles.

Ivory rod implants were found to be biologically unacceptable in rabbit mandibles. Fibrous connective-tissue capsules containing numerous multinucleated giant cells formed around the implants. Resorption of the ivory was also apparent. In addition, osteoid deposition and ankylosis at the experimental sites were not evident.

Animals↗
PubMedDate not supplied

Dental infection control at the year 2000. Accomplishment recognized.

OVERVIEW: Health care providers have strived to address the many elements necessary to achieve effective infection control. Historical progress in microbiology and hospital asepsis provided the foundation for advances in dental preventive practices. Evidence supporting the application of current practices includes a long history of scientific and clinical investigations, technological advances in equipment and materials, and periodic publication of updated recommendations by professional health care organizations. CLINICAL IMPLICATIONS: The routine application of precautions such as multiple aseptic procedures, latex gloves, masks, protective eyewear, clinic coats, automated instrument decontamination devices, time-efficient heat sterilization modalities, chemical disinfectants, waste management procedures and single-use disposable items have created a safer environment for dental personnel and patients alike.

Asepsis↗
PubMedDate not supplied

Antibiotic resistance and maxillofacial pathogens: emerging treatment issues.

The practice of using antibiotics to treat and control microbial infections is a little more than 50 years old. Widespread administration of multiple classes of antibiotics over the years has had the unfortunate secondary effect of inducing the emergence of an increasing array of drug-resistant microbial strains. This article will discuss the evolution of certain forms of antibiotic resistance, as well as the mechanisms by which bacteria render numerous antimicrobials ineffective. Special emphasis is placed on emerging issues relating to organisms making up portions of the normal oral microflora.

Bacteria, Anaerobic↗
PubMedDate not supplied

Study on adequacy of sterilization of air-water syringe tips.

This study examined the adequacy of sterilization of air-water syringe (AWS) tips following contamination during routine dental care treatment procedures. Although the internal chambers of most AWS tips were determined to be contaminated following use, no residual microbes were detected following autoclave sterilization of the AWS tips used during patient treatment procedures. Therefore, AWS tips apparently are readily heat sterilizable by conventional methods following clinical usage.

Dental Instruments↗
PubMedDate not supplied

Histological effects of a coupled tumor protein antigen on the development of transplanted tumors in C3H/HeJ mice.

Two hundred 13 week old male and female C3H/HeJ mice were used to gauge the histological effects of a coupled tumor protein antigen (CTPA) on the development of transplanted tumors in these inbred mice. A group of the animals was transplanted with 2mm3 pieces of neoplastic tissue derived from a single spontaneous adenocarcinoma excised from a retired breeder C3H/HeJ female mouse. One hundred of these transplanted animals were subsequently injected with 0.2 ml of CTPA via a hind foot pad at weekly intervals, while others were left untreated. The transplanted tumors were allowed to develop for six weeks, at which time they were excised both from treated and nontreated animals, prepared according to standard histological techniques and stained with hematoxylin and eosin. Examination of the stained tissues revealed numerous chronic inflammatory cells in neoplasms from transplanted CTPA-treated animals. Tissue disruption, lymphocytic infiltration and macrophage-mediated phagocytosis were in evidence. In contrast, analogous tissues from transplanted control mice did not exhibit any manifestations of cellular immunity or chronic inflammation. It would appear, then, that a degree of cell-mediated immunity was induced in animals treated with CTPA.

Animals↗