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Biomedical subjects

J A Ochoa

Publications and source records attributed to J A Ochoa.

9 recordsLinked to original sources
PubMed2001

"In vivo" determination of hip joint separation and the forces generated due to impact loading conditions.

Numerous supporting structures assist in the retention of the femoral head within the acetabulum of the normal hip joint including the capsule, labrum, and ligament of the femoral head (LHF). During total hip arthroplasty (THA), the LHF is often disrupted or degenerative and is surgically removed. In addition, a portion of the remaining supporting structures is transected or resected to facilitate surgical exposure. The present study analyzes the effects of LHF absence and surgical dissection in THA patients. Twenty subjects (5 normal hip joints, 10 nonconstrained THA, and 5 constrained THA) were evaluated using fluoroscopy while performing active hip abduction. All THA subjects were considered clinically successful. Fluoroscopic videos of the normal hips were analyzed using digitization, while those with THA were assessed using a computerized interactive model-fitting technique. The distance between the femoral head and acetabulum was measured to determine if femoral head separation occurred. Error analysis revealed measurements to be accurate within 0.75mm. No separation was observed in normal hips or those subjects implanted with constrained THA, while all 10 (100%) with unconstrained THA demonstrated femoral head separation, averaging 3.3mm (range 1.9-5.2mm). This study has shown that separation of the prosthetic femoral head from the acetabular component can occur. The normal hip joint has surrounding capsuloligamentous structures and a ligament attaching the femoral head to the acetabulum. We hypothesize that these soft tissue supports create a passive, resistant force at the hip, preventing femoral head separation. The absence of these supporting structures after THA may allow increased hip joint forces, which may play a role in premature polyethylene wear or prosthetic loosening.

Biomechanical Phenomena↗
PubMed1999

Simulation of initial frontside and backside wear rates in a modular acetabular component with multiple screw holes.

A sliding distance-based finite element formulation was implemented to predict initial wear rates at the front and back surfaces of a commercially available modular polyethylene component during in vitro loading conditions. We found that contact area, contact stress, and wear at the back surface were more sensitive to the liner/shell conformity than the presence of multiple screw holes. Furthermore, backside linear and volumetric wear rates were at least three orders of magnitude less than respective wear estimates at the articulating surface. This discrepancy was primarily attributed to the difference in maximum sliding distances at the articulating surfaces (measured in mm) versus the back surface (measured in microm). This is the first study in which backside wear has been quantified and explicitly compared with frontside wear using clinically relevant metrics established for the articulating surface. The results of this study suggest that with a polished metal shell, the presence of screw holes does not substantially increase abrasive backside wear when compared with the effects of backside nonconformity.

Acetabulum↗
PubMed1998

Backside nonconformity and locking restraints affect liner/shell load transfer mechanisms and relative motion in modular acetabular components for total hip replacement.

Nonconformity between the polyethylene liner and the metal shell may exist in modular acetabular components by design, due to manufacturing tolerances, or from locking mechanisms that attach the polyethylene liner to the metal shell. Relative motion at the liner/shell interface has been associated with backside wear, which may contribute to osteolysis which has been clinically observed near screw holes. The purpose of this study was to investigate the effect of nonconformity and locking restraints on the liner/shell relative motion and load transfer mechanisms in a commercially available, metal-backed acetabular component with a polar fenestration. The finite element method was used to explore the hypothesis that backside nonconformity and locking restraints play important roles in long-term surface damage mechanisms that are unique to modular components, such as backside wear and liner extrusion through screw holes. The three-body quasi-static contact problem was solved using a commercially available explicit finite element code, which modeled contact between the femoral head, polyethylene liner, and the metal shell. Four sets of liner boundary conditions were investigated: no restraints, rim restraints, equatorial restraints, and both rim and equatorial restraints. The finite element model with a conforming shell predicted between 8.5 and 12.8 microm of incremental extrusion of the polyethylene through the polar fenestration, consistent with in vitro experiments of the same design under identical loading conditions. Furthermore, idealized rim and/or equatorial liner restraints were found to share up to 71% of the load across the liner/shell interface. Consequently, the results of this study demonstrate that backside nonconformity and locking restraints substantially influence backside relative motion as well as load transfer at the liner/shell interface.

Acetabulum↗
PubMed1997

In vivo observations of hydraulic stiffening in the canine femoral head.

The role that intertrabecular contents and their boundary conditions have on the dynamic mechanical response of canine femoral heads was investigated in vivo. Femoral heads from paired intact hind limbs of canine specimens were subjected to a sinusoidal strain excitation at physiologic frequencies, in the cranio-caudal direction. The fluid boundary conditions for the contralateral limbs were changed by predrilling through the lateral femoral cortex and into the femoral neck. The drilling procedure did not invade the head itself. This femoral head fluid boundary alteration reduced the stiffness by 19 percent for testing at 1 Hz. The results of this study demonstrate that fluid stiffening occurs in vivo as previously observed ex vivo.

Animals↗
PubMed1995

Finite element analysis in the design and characterization of an absorbable cement restrictor.

The benefit of using a cement restrictor to achieve cement pressurization during total hip arthroplasty is well established. An absorbable cement restrictor design has been developed with the use of a finite element model. The non-linear axisymmetric model was used to optimize specific parameters so as to perform within acceptable limits when tested over a specified range of medullary canal sizes. The results achieved from a hybrid experimental/analytical design methodology allowed for a shorter development cycle for the initial size and each additional size in the design family thereafter. The resulting cement restrictor design was compared to and exceeded the performance of currently clinically accepted devices in resisting migration.

Biomechanical Phenomena↗
PubMed1991

Stiffening of the femoral head due to inter-trabecular fluid and intraosseous pressure.

The mechanical properties of cancellous bone, as measured from bone plug samples have been widely documented. However, few tests have been attempted to explore the effects the intertrabecular contents may have on the load bearing capabilities. In this study, canine femoral heads were subjected to dynamic compressive strain cycles. The femoral heads were tested intact, as well as with disrupted boundary conditions of the continuous, intraosseous fluid space. A significant reduction in mechanical stiffness was observed when the fluid compartment boundary was disrupted by drilling a hole part way into the femoral neck. A finite element model of a typical femoral head showed that the stiffness change was not due to removal of material from the neck, hydraulic effects notwithstanding. Refilling the hole in the neck with saline solution and sealing the boundary restored the stiffness to the intact baseline level. However, an increase in the fluid pressure did not cause a statistically significant increase in the stiffness of the femoral head.

Animals↗
PubMed1991

The effect of intertrabecular fluid on femoral head mechanics.

The effect of intraosseous fluid on the mechanical characteristics of bone is unclear. To determine the potential effects of alteration in the fluid boundary conditions of the femoral head, a decompression procedure was performed. The stiffness of femoral heads from normal adult mongrel dogs was measured after the heads were subjected to a physiologic mechanical load. When the fluid boundary conditions were altered by drilling the femoral neck, femoral head stiffness was reduced by more than 30% (p = 0.045). Refilling of the femoral specimen with saline restored the stiffness to the baseline value. These observations demonstrate that in vitro changes of fluid boundary conditions can alter the mechanical integrity of the femoral head. Alteration in osseous fluid boundary conditions in vivo could affect joint integrity and be of pathogenetic significance in joint disease.

Animals↗
PubMed1987

Determination of cell membrane permeability in concentrated cell ensembles.

The method of volume averaging is used to analyze the process of diffusion in concentrated cell ensembles in which significant resistance to mass transfer is caused by the cellular membrane. A general closure scheme is given that allows for direct theoretical prediction of effective diffusivities for any cellular geometry. Numerical results are presented for the classical parallelepiped arrangement used to model cellular systems, and these results are used in conjunction with experimental studies of concentrated cell ensembles to determine membrane permeabilities for solute diffusion in several cellular systems. Membrane permeabilities are compared with predictions from other models of diffusion in cellular systems.

Animals↗