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Biomedical subjects

J A Richardson

Publications and source records attributed to J A Richardson.

17 recordsLinked to original sources
PubMed1991

A temperature-dependent rabbit model for production of dermal lesions by Haemophilus ducreyi.

The fact that optimal in vitro growth of Haemophilus ducreyi occurs at 33 degrees C prompted evaluation of the effect of temperature on the ability of this organism to produce skin lesions in rabbits after intradermal inoculation. Animals housed at a reduced ambient temperature (15-17 degrees C) consistently developed necrotic lesions when injected intradermally with 10(5) cfu of H. ducreyi; this inoculum did not produce necrotic lesions in animals housed at normal room temperature (23-25 degrees C). Lesion production in this new model was dependent on both viability of the H. ducreyi inoculum and replication of these organisms after intradermal injection. Histopathologic examination of the lesions revealed that H. ducreyi infection of the rabbit dermis evolves from an acute inflammatory reaction to abscess formation. Evaluation of three additional strains of H. ducreyi in this model confirmed that lesion formation was not bacterial strain-dependent. This new temperature-dependent rabbit model for productive H. ducreyi infection will facilitate investigation of the molecular pathogenesis of chancroid.

Animals↗
PubMed1978

Counseling women for tubal sterilization.

In view of the current concern about sterilization abuse, the federal government has issued guidelines to prevent women from being sterilized without their knowledge or consent. The authors describe a counseling program in a large inner-city hospital that followed these specifications.

Adolescent↗
PubMed1978

Diabetes insipidus and pregnancy. Case report, incidence and review of literature.

The coexistence of diabetes insipidus (D.I.) and pregnancy is rare. Sixty-seven cases are reviewed, including one of our own. The condition tends to become worse in pregnancy, labor appears unaffected and lactation appears to lead to an improvement in D.I. Theories are discussed to account for the effect of pregnancy on D.I.

Adult↗
PubMed1978

A cervimeter for continuous measurement of cervical dilatation in labour-preliminary results.

We briefly review instruments that have been used to measure cervical dilatation and describe the development of a new cervimeter. Curves derived from cervical dilatation and intrauterine pressure traces are presented in a form that clearly records the activity of the uterus and the response of the cervix to individual contractions. Our results suggest a new concept for behaviour of the cervix in labour.

Anthropometry↗
PubMed1976

Effects of legal termination on subsequent pregnancy.

Two hundred and eleven patients who had undergone vaginal termination and were pregnant again were investigated; 43-2% had become pregnant within one year of termination. The overall fetal loss in the 211 patients was 17-5% compared with 7-5% in a group matched for parity but consisting of patients who were pregnant after a spontaneous abortion. Altogether 4-3% of pregnancies after legal abortion ended as first trimester abortions, 8-5% as second trimester abortions, and 13-7% in premature delivery. Among 11 women whose cervices had been lacerated at the time of legal termination the fetal loss in subsequent pregnancy was 45-5%, and only one pregnancy went beyond 36 weeks. Routine Shirodkar suture may be beneficial when the cervix is known to have been damaged at legal abortion. Several patients had asked that their general practitioner should not be told of their termination, and such patients may not admit their termination during a subsequent pregnancy, which could thus be jeopardised. No evidence was found to suggest that infants of patients with a history of legal termination are small for dates.

Abortion, Induced↗
PubMed1976

Nervous signs in bovine coccidiosis.

In 2 outbreaks of coccidiosis due to E bovis and/or E zurnii infection in Canadian cattle, nervous signs included opisthotonos, medial strabismus, hypersensitivity, tetanic spasms, and convulsions. All of the affected animals died in convulsions after an illness of one to several days during which time they showed periodic nervous signs. Necropsy revealed a very severe enteritis with the most severe lesions in the spiral colon. Much of the intestinal mucosa in this area had been destroyed by the parasite. None of several suggested causes of such nervous signs was indicated by laboratory findings, but the possibility of toxins produced by the coccidia could not be ruled out.

Animals↗
PubMed1976

The development of an instrument for monitoring dilatation of the cervix during labour.

The measurement of cervical dilatation during labour is of fundamental importance to the obstetrician as it indicates the progress of labour. This paper reviews instruments that have been used to measure cervical dilatation in the past and describes the development of an instrument, originally intended to measure both effacement of the cervix and cervical dilatation, but which, because of technical problems, resulted in an instrument measuring cervical dilatation only. The instrument is non-traumatic, accurate, and easy to apply. As well as the clinical application, the instrument has been found useful in studying mechanism of dilatation. Preliminary results have shown that the cervix opens in an oscillatory manner dictated by the strength and period of uterine contractions. It can even close slightly following a series of weak contractions. Further clinical trials are planned.

Cervix Uteri↗
PubMed1975

Long-term therapy for chronic bacteriuria in men. U.S. Public Health Service cooperative study.

Response to therapy, renal function, and mortality were analyzed in a prospective study of 249 men with bacteriuria followed for up to 10 years. All patients received initial organism-specific antibiotic therapy followed by 2 years of continuous treatment with sulfamethizole, nitrofurantoin, methenamine mandelate, or placebo. Continuous therapy with active drugs delayed recurrence of bacteriuria and reduced acute clinical exacerbations of infection. Patients with pure Escherichia coli bacteriuria, normal intravenous pyelogram, no previous therapy, and a normal prostate had a good prognosis with short-term antibiotic therapy alone. The presence of prostatic or upper urinary tract calculi, pyelonephritic scars, or mixed or enterococcal infections predicted a poor bacteriologic prognosis. In the absence of severe urologic disease or concomitant noninfectious renal disease no patients with persistent bacteriuria developed renal failure. Continuous antibiotic therapy is of value in selected male patients with bacteriuria in reducing recurrence and acute clinical exacerbations of urinary tract infection.

Adult↗