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Biomedical subjects

J A Schilling

Publications and source records attributed to J A Schilling.

At least 19 recordsLinked to original sources
PubMed1985

Advances in knowledge related to wounding, repair, and healing: 1885-1984.

The purpose of this paper is to record objectively the contribution of Annals of Surgery to the development of the science of surgery and its application to patient care in commemoration of its Centennial. Though many other subjects could have been chosen, the literature relating to wounding, repair, and healing is pertinent to all of surgery and uniquely comprises a significant portion of its history and science. By reviewing the articles and content of the 200 volumes, a personal perspective was gained and hopefully captured in the body of the manuscript. By departing from the usual format of a bibliography, names of authors appear rather than impersonal numbers. The editorial eras are apparent, punctuated by the beginnings, the World Wars, the Wars of Korea, Vietnam, and North Africa, the development of biomedical research, and the technologies in other fields. Annals also reflects the logarithmic increase in higly competent surgeons through the burgeoning educational programs of university health centers, major hospitals, and clinics in the United States and in other parts of the world. Societal needs and problems are reflected by the scope and breadth of the surgical articles in response to the medical needs of its constituents during war and peace. The evolution of specialization is apparent from the beginning. Declining morbidity and mortality rates reflect the application of research, technology, and experience to the science of surgery and the biology of wounds through their dissemination.

General Surgery↗
PubMed1980

Gastric pH monitoring as a prognostic indicator for the prophylaxis of stress ulceration in the critically III.

Previous studies have documented the efficacy of prophylaxis in the prevention of stress ulceration and bleeding in critically ill patients. In an effort to determine whether all critically ill patients require prophylaxis, 144 patients admitted to an intensive care unit were monitored by continuous indwelling nasogastric or gastrostomy tubes. Any patient with a measured gastric pH of less than 4 was treated with prophylactic cimetidine or antacids to maintain a pH of 4 or greater. One hundred twenty-three (85 percent) met this criterion. The gastric pH of 21 patients (15 percent) never fell below 4 during continuous monitoring for 26+/- 4.2 hours. There was a significantly lower incidence of hypotension and respiratory failure in this group ( pl < 0.05). Mortality was higher in the patients who required prophylaxis (15 percent) than in those who did not (0 percent). No bleeding was encountered in any patient in either group. These data suggest that patients who do not require prophylaxis may be determined by continuous monitoring of intragastric pH. If, within 24 hours, intragastric pH does not fall below 4, minimal indications for prophylaxis exist. Intragastric pH monitoring is a simple, effective tool in the care and management of critically ill or traumatized patients.

Adult↗
PubMed1977

Wound complications.

An analysis of the wound complications in a six-month period on the Surgical Service of the University of Washington Hospitals is presented. A total of 9.9% of these patients had wound complications of one type or another, singly or in combination. The importance of their record and analysis in the total care of the surgical patient is emphasized.

Humans↗
PubMed1976

Wound healing.

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Bandages↗
PubMed1974

The fine structure of experimentally induced connective tissue complexes in the human.

The growth, development and cellular activity of fibrocollagenous tissue complexes induced by the implantation of specially structured wire mesh cylinders in 22 human male volunteers were studied during the time course of fibroplasia utilizing light and electron microscopic techniques. The fibrocollagenous tissue complexes after 4 to 16 weeks of development demonstrated highly ordered lamellations made of zones consisting primarily of fibroblasts and zones consisting primarily of collagenous fibers. The development of the ordered lamellations is referable to specific fibrillogenic activities by the constituent fibroblasts. The initial role of the fibroblast in fibrillogenesis is indicative of an apocrine-like secretory process followed by a holocrine-like role which results in cytodestruction and concurrent formation of an avascular collagenic tissue referable to an organizing cicatrix in a healing wound.

Cell Membrane↗