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Biomedical subjects

J A Seab

Publications and source records attributed to J A Seab.

6 recordsLinked to original sources
PubMed1992

Dysplastic nevi and the dysplastic nevus syndrome.

Patients with all the clinical features of FDNS but no family history of multiple abnormal nevi or melanoma can be compared with patients with neurofibromatosis due to a spontaneous mutation of the gene in utero. Whether or not such patients are in fact genetically identical to patients with FDNS and share their high risk of malignant melanoma remains to be determined. An isolated dysplastic nevus alone is not an adequate definition of SDNS, because current data are insufficient to show that its presence correlates with a uniquely high risk of melanoma when compared with other known risk factors. Until more specific tests for the FDNS gene become available, the diagnosis of SDNS must be made on the basis of close clinical and histopathologic resemblance to FDNS. Patients who present as adults with one or a few dysplastic nevi are best not labeled as having SDNS, because that label implies a genetic identity with FDNS that is probably not true and that deflects attention from other risk factors that are at least as important in estimating individual risks of developing melanoma.

Diagnosis, Differential↗
PubMed1989

Deep penetrating nevus.

We report a clinical and histologic study of 70 patients, each with a single melanocytic lesion termed "deep penetrating nevus" (DPN). The lesions are most commonly found on the face, upper trunk, or proximal extremities of patients between the ages of 10 and 30 years. Typically they are darkly pigmented. Histologically they are characterized by loosely organized nests of pleomorphic pigmented cells that penetrate deep into the reticular dermis and often to the subcutaneous fat. Follow-up was obtained from 48 patients. It ranged from 1 to 23 years (mean, 7 years). Despite an initial histologic diagnosis of malignant melanoma in 29% of the cases, there were no local recurrences and no distant metastases. It is important to differentiate DPN from malignant melanoma. The characteristic histologic features of DPN also allow its differentiation from spindle cell and epithelioid cell nevi and blue nevi.

Adolescent↗
PubMed1987

Primary cutaneous adenoid cystic carcinoma.

Primary adenoid cystic carcinoma of the skin is rare. Ten cases from the files of the Armed Forces Institute of Pathology were studied. Seven of the 10 cases recurred after initial surgery. The interval between surgery and recurrence ranged from 4 months to 20 years. In one case there was metastasis to lung and pleura. Histologically, cutaneous adenoid cystic carcinoma is indistinguishable from adenoid cystic carcinoma of the salivary gland. The diagnostic histologic features and the differentiation of adenoid cystic carcinoma from other cutaneous neoplasms are discussed.

Adult↗
PubMed1983

Anatomy and pathology of extrapyramidal diseases.

An overview of the anatomy of the basal ganglion system has been presented in conjunction with a brief outline of the diseases associated with it. The etiology of these degenerative diseases has been discussed, and the major morphologic changes at the macroscopic level are given. The probable pathologic and morphologic substrates of movement disorders have been suggested.

Basal Ganglia↗
PubMed1977

Intracerebral delayed hypersensitivity reactions in glioblastoma multiforme patients.

Patients with malignant gliomas who had undergone BCG inoculation were injected intratumorally with PPD to induce an intratumoral delayed hypersensitivity reaction. Histopathological examination of the tumor before and after PPD injections revealed that chronic inflammatory responses were increased after injection in four of the five patients. In no case, however, was the response more than moderate, and in no case did the inflammatory response encompass the tumor at its peripheral margins. Intracerebral delayed hypersensitivity reactions were evoked in humans with acceptable morbidity. The mild reactions evoked did not cause detectable tumor regression.

Adolescent↗