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Biomedical subjects

J A Sereno Colo

Publications and source records attributed to J A Sereno Colo.

6 recordsLinked to original sources
PubMed1994

[The efficacy of sulbactam-ampicillin in preventing postoperative infections in gynecology and obstetrics. A comparative open study].

An open comparative and multicentric trial was carried out to assess the activity of sulbactam ampicillin combination against no treatment, as a prophylactic agent of post-surgical infection in ob-gyn practice. 100 patients were included in the trial and distributed in two groups. sulbactam/ampicillin 0.5/1.0 g, i.v. was administrated during the surgery and the dose was repeated 6 h. later. No cases of post-surgical infection was detected in the group of sulbactam/ampicillin, while 4 cases were observed in the no treatment group. Sulbactam/ampicillin is an effective and well tolerated antimicrobial agent in the prophylaxis of post-surgical infections.

Adolescent↗
PubMed1993

[Effect of a combination of gestoden-ethylene estradiol on the endometrium].

It has been long established that contraceptive steroid mixtures are highly effective due to the fact that they act simultaneously upon different levels of the pituitary-ovarian-genital tract axis. We hypothesized that the mixture of 30 mcg of ethynylestradiol plus 75 mcg of gestodene might be effective partly through the changes it induces in the histology and histochemistry of the endometrium. To test this hypothesis, 32 healthy patients willing to participate, aged 23 to 34 years, were treated with the above mentioned combination of steroids from day 1 through day 21 of the cycle for six consecutive cycles. They were previously proven to be fertile and ovulatory. In ten of them, selected at random, an endometrial biopsy was taken on the cycle previous to therapy and upon completion of the steroid treatment, for comparison. Tissues were processed for histologic evaluation with hematoxylin-eosin and with acridine orange for the histochemical demonstration of glycogen and ribonucleic acid under fluorescence microscopy. All pre-treatment endometria showed normal findings for ovulatory cycles, while the post-treatment tissues were typical of the steroid-treated endometria, i.e., they had a disrupted balance between glandular and stromal maturation, plus a diminished and abnormally distributed glycogen and ribonucleic acid. We conclude that the established working hypothesis was confirmed.

Adult↗
PubMed1990

[Septic shock in obstetrics].

Septic shock in obstetrics is a major cause of mortality. Postpartum endometritis is often the first step of bacterial colonization inside the uterus which becomes the nidus of infection. Rapid spread into general circulation is favoured by hemodynamics patterns of pregnancy. Bacteremia would result in cardiovascular collapse and a myocardial depressant factor has been proposed to explain the fall in cardiac output. Later, endotoxin activates the substances of malignant intravascular inflammation and multiple systems organ failure may be observed in uncontrolled sepsis. Eight cases are reported hospitalized at Morelia's General Hospital, SSA, with septic shock and MSOF. Presumably because of aggressive acute resuscitation nobody succumbed during acute cardiac failure and hypotensive episode but two patients died later with multiple system organ failure. The mortality was 25%. Fluid, resuscitation, and vasoactive drugs are the most effective way to reduce mortality. Antibiotics, specific treatment of MSOF and taking away the nidus of infection are critical components of therapy.

Anti-Bacterial Agents↗
PubMed1989

[Abdominal pregnancy. An unusual case].

A general review is made about concept, incidence and clinical features of abdominal pregnancy. The early and accurate diagnosis of an abdominal pregnancy is very important in order to avoid catastrophic hemorrhage from placental separation. A case is reported of a young woman hospitalized at Morelia's General Hospital, SSA, with an abdominal pregnancy. The fetus died about 26th week and underwent mummification. Some time later the fetus spontaneously divided and the lower segment extruded through the intestines. The remain upper thoracic and cephalic segment was removed at laparotomy closing an intestine stoma; 60% of the placenta was also removed. The postoperative course was uneventful.

Adolescent↗