PubMed Health⌕ Search

Biomedical subjects

J A Spinks

Publications and source records attributed to J A Spinks.

14 recordsLinked to original sources
PubMed2001

The neural system underlying Chinese logograph reading.

Written Chinese as logographic script differs notably from alphabets such as English in visual form, orthography, phonology, and semantics. Thus, research on the Chinese language is important to advance our understanding of the universality and particularity of the organization of language systems in the brain. In this study, we examine the neural systems associated with logographic reading using functional magnetic resonance imaging. Two experimental tasks were devised, one based on semantic decision and the other on homophone decision. Compared to the fixation baseline, peak activations resulting from semantic as well as homophony decisions were localized in the left middle frontal gyrus (BA 9). Left inferior frontal cortex also mediated Chinese processing. In addition, more right hemisphere cortical regions (i.e., BAs 47/45, 7, 40/39, and the right visual system) were involved in reading Chinese relative to reading English. This is attributed to the square shape of the logograph which requires an elaborated analysis of the spatial information and locations of various strokes comprising the logographic character. We suggest that the left middle frontal area (BA 9) coordinates and integrates the intensive visuospatial analysis demanded by logographs' square configuration and the semantic (or phonological) analysis required by the present experimental tasks. Our study has implicated brain regions common to both logographic and alphabetic languages as well as brain regions specialized in processing logographs.

Adult↗
PubMed2001

Cerebral hemodynamic response in Chinese (first) and English (second) language processing revealed by event-related functional MRI.

Comparative functional neuroimaging studies using the block design paradigm have previously demonstrated that there are no significant differences in the location of areas of cerebral activation when native Chinese speakers independently process single words or sentences in both the Chinese (first) and English (second) languages. While it has also been documented that significant domains of brain response include the inferior to middle left frontal lobe, the latency, amplitude and duration of the associated hemodynamic changes during isolated neural processing of Chinese and English languages still remain unknown. The aim of this study, therefore, was to examine the characteristics of the hemodynamic alterations in the above-mentioned regions with event-related functional MRI (ER-fMRI) when native Chinese speakers performed verb generation tasks in both the Chinese (first) and English (second) languages. Our results demonstrate the presence of a similar neural activity-induced hemodynamic response in the inferior to middle left frontal lobe during both tasks. Further, there were also no statistically significant differences among the variables that described the hemodynamic response curves. These findings strongly imply that the underlying neural mechanism for Chinese (first) and English (second) language processing may be similar in native Chinese speakers.

Adult↗
PubMed2000

Reading Chinese characters for meaning: the role of phonological information.

Two experiments with the Stroop paradigm were conducted to investigate the role of phonological codes in access to the meaning of Chinese characters. Subjects named the ink color of viewed characters or color patches. Key items were color characters, their homophones with the same tone, homophones with different tones, and semantic associates. Apart from finding the usual Stroop interference effect, homophones produced significant interference in the incongruent condition, provided that they had the same tone as the color characters. The interference effect from homophones, however, was significantly smaller than that from color characters. Semantic associates generated an interference effect in the incongruent condition, an effect of the same magnitude as the effect from the same-tone homophones. Finally, in the congruent conditions, all the key items yielded facilitations compared to neutral controls, though the facilitation from color characters was larger than the facilitations from other types of characters. These findings suggest that phonological codes in Chinese are activated obligatorily and provide early sources of constraint in access to meaning.

Cognition↗
PubMed2000

Brain activation in the processing of Chinese characters and words: a functional MRI study.

Functional magnetic resonance imaging was used to identify the neural correlates of Chinese character and word reading. The Chinese stimuli were presented visually, one at a time. Subjects covertly generated a word that was semantically related to each stimulus. Three sorts of Chinese items were used: single characters having precise meanings, single characters having vague meanings, and two-character Chinese words. The results indicated that reading Chinese is characterized by extensive activity of the neural systems, with strong left lateralization of frontal (BAs 9 and 47) and temporal (BA 37) cortices and right lateralization of visual systems (BAs 17-19), parietal lobe (BA 3), and cerebellum. The location of peak activation in the left frontal regions coincided nearly completely both for vague- and precise-meaning characters as well as for two-character words, without dissociation in laterality patterns. In addition, left frontal activations were modulated by the ease of semantic retrieval. The present results constitute a challenge to the deeply ingrained belief that activations in reading single characters are right lateralized, whereas activations in reading two-character words are left lateralized.

Adult↗
PubMed1994

Asymmetrical cross-language priming effects.

Three experiments were conducted to examine cross-language priming in bilinguals. The first was a cross-language primed lexical decision task experiment with Chinese-English bilinguals. Subjects made lexical decisions about primary associate targets in the two languages at the same rate, but priming occurred only when the prime was in their first language (L1), Chinese, and the target was in their second language (L2), English. Experiment 2 produced the same pattern of asymmetrical priming with two alphabetic languages, French and Dutch. In Experiment 3, the crucial stimuli were translation equivalents. In contrast to the results of Experiments 1 and 2, priming occurred across languages in both the L1-L2 and L2-L1 conditions. However, this priming was also asymmetrical, with more priming occurring in the L1-L2 condition. A tentative separate-interconnected model of bilingual memory is described. It suggests that the representations of words expressed in different languages are stored in separate memory systems, which may be interconnected via one-to-one links between some translation-equivalent representations as well as meaning-integration processes.

China↗
PubMed1993

Coping strategies of schizophrenic patients and their relationship to outcome.

The experience and perception of effective sources of help of 101 schizophrenic patients were studied. A combination of professional help, social support, and self-coping efforts was listed as helpful. The more experiences patients had with the various sources of help, the better were their outcomes. Premorbid adjustment, exposure to the magnitude and nature of helpful sources, as well as the patients' own ability and motivation to make use of available helpful sources were thought to be important mediating variables for a better outcome. Apart from psychotropic medications, over half of the patients were not using any one of the sources of help mentioned. It remains an important research question whether or not schizophrenic patients may benefit from direct coaching in self-help skills in conjunction with making optimal use of professional and environmental supports.

Adaptation, Psychological↗
PubMed1992

Particulate air pollution and hospitalization for asthma.

Age-specific quarterly asthmatic hospital discharge rates in Hong Kong during 1983 to 1989 were examined in relation to mean levels of six pollutants: sulfur dioxide (SO2), ozone (O3), total suspended particles (TSP), respiratory suspended particles (RSP), nitrogen dioxide (NO2), and nitrogen oxides (NOX). Discharges from the hospital of children under 14 years of age represented 56% of 33,952 discharges recorded in all age groups. Trends of adult hospitalization rates over time remained stable during the study period. In children, however, there was an increase in these rates, particularly marked in the age group of 1 to 4 years. Univariate analysis revealed a strong correlation between quarterly mean TSP and hospital discharge rate for the 1 to 4-year-old children (r = .62, P less than .001). In the 5 to 14-year-old age group, there was an inverse relationship between hospital discharge rate and sulfur dioxide level (r = -.38, P less than .05). Stepwise multiple regression analysis, controlling for confounding variables (seasonal and annual trends of asthma hospitalizations) confirmed these relationships. A highly significant linear regression equation was derived between hospitalization rate for ages 1 to 4 years and total suspended particles (P less than .001). The highly significant correlation between pollution and asthmatic hospitalization rate for the 1 to 4-year-old group suggests that young children are vulnerable to the adverse environmental effects of pollution. Auditing these relationships offers a logical basis for approaching control.

Adolescent↗
PubMed1991

Patterns of outcome in schizophrenia in Hong Kong.

A total of 153 schizophrenic subjects were included for outcome assessment in different aspects of their life functions. The same group of subjects was followed-up 1 year later to assess the consistency of their outcome pattern. A factor analysis on the outcome measures was conducted, and 5 independent factors were noted. Outcome on symptomatic control was most favourable but less consistent over time. Psychosocial deficits, on the other hand, were more enduring and noted in a significant proportion of the subjects.

Activities of Daily Living↗
PubMed1985

The effects of anticipated information on skin conductance and cardiac activity.

This experiment examined electrodermal and cardiac activity within a two-stimulus anticipation paradigm. A warning stimulus informed subjects (N = 24) whether an imperative stimulus to follow would contain two or four letters (low or high information conditions) and whether this stimulus would be presented for 60 or 75 msec (short or long duration). The subject's task was to identify as many of the letters in the imperative stimulus as possible. Although the amount of information conveyed by the warning stimulus was identical throughout the experiment (2 bits), skin conductance responses during the warning stimulus-imperative stimulus interval were larger prior to the high information imperative stimulus than prior to the low. Cardiac activity was not affected by the experimental manipulations. The implications of these findings for theories of the orienting response are discussed, particularly with reference to the view that orienting reflects an activation of the information processing system.

Adolescent↗
PubMed1985

Effect of the orienting response on sensory discriminability.

The effects of orienting responses to different types of stimuli on acquisition of information were studied. Subjects underwent a standard habituation series of 15 trials. On Trial 16, they received one of following three stimuli: (a) no-change stimulus--same stimulus as habituation stimulus, (b) innocuous-change stimulus, (c) significant-change stimulus--the subject's own name. These orienting stimuli were followed 500 msec. later by an imperative stimulus (100 msec.) which contained a number of Chinese characters. The subjects were then unexpectedly asked to recall and recognize these characters. Recall and recognition were consistently superior in conditions with significant and innocuous change relative to no change, which indicated that the orienting response to unexpected stimuli is related to a generalized perceptual enhancement. The data pose problems for the position that the orienting response reflects only the passive 'registration' of the eliciting stimulus information. While digital pulse-amplitude data showed no difference among the conditions for the change trial, these conditions were differentiated by electrodermal and cardiac changes.

Adolescent↗
PubMed1976

Effects of stimulus information and stimulus duration on amplitude and habituation of the electrodermal orienting response.

This study was designed to investigate the effects of stimulus information and stimulus duration on the skin conductance response (SCR) component of the orienting response (OR). Three levels of stimulus information were combined with two levels of stimulus duration in a 3 X 2 independent groups factorial design (N = 90). On the basis of Sokolov's (1966) theory, it was hypothesized that: (a) high information stimuli would elicit larger initial SCR'S than would stimuli of low information, (B) high-information stimuli would evoke more SCRs throughout a habituation series than would low-information stimuli, and (c) high-information stimuli would require more presentations to reach a habituation criterion than would stimuli of low information. It was also hypothesized that (d) long-duration stimuli would require fewer presentations to reach a habituation criterion and result in a faster rate of habituation than would stimuli of short duration. The stimuli consisted of black and white chequered patterns containing 12, 26 or 60 bits of information. Stimulus duration was either 0.5 or 4.5 sec, and each subject received 20 presentations at randomly ordered intervals of 20, 25, 30 and 35 sec. The results provided support for hypotheses (b), (c) and (d), but not for hypothesis (a). These results support the view that OR habituation can be conceptualized as a process of information extraction.

Adolescent↗