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J A TIBBLES

Publications and source records attributed to J A TIBBLES.

6 recordsLinked to original sources
PubMed1964

SUBACUTE INCLUSION ENCEPHALITIS: A CLINICAL AND PATHOLOGICAL REVIEW.

Subacute inclusion encephalitis has been reported most frequently from Western Europe; only 16 cases have been described in North America. During the past eight years the authors have encountered 14 cases in the Toronto area, and histological confirmation has been obtained in seven of these.The disease most often presents as a combination of progressive personality and intellectual deterioration combined with myoclonic seizures or drop attacks and focal neurological deficits, although extrapyramidal symptoms or evidence of raised intracranial pressure may also occur.At the time of the initial presentation the EEG was characteristic in only nine of the 14 cases, but a first-zone rise in the colloidal gold curve was present in all cases in which it was carried out.From the pathological features of the disease, as described, and its absence of familial occurrence, it is concluded that a viral origin is most probable, although its rarity and predilection for a particular age group are unusual.

Canada↗
PubMed1963

Trial of amino-oxyacetic acid, an anticonvulsant.

It has been shown experimentally that the drug amino-oxyacetic acid (AOA) can raise the level of gamma aminobutyric acid (GABA) in the brain. Since GABA is a powerful neuronal inhibitor it seemed worth while to assess the value of AOA as an anticonvulsant.This drug was given to 23 infants and children, all but one of whom were resistant to usual anticonvulsant medication. The types of seizure patterns were classed as major (including focal) and minor (akinetic, myoclonic and hypsarrhythmic) and the patients were followed for up to one year. Of eight children with major seizures, five were improved; of eight with minor seizures, three were improved; and of six with hypsarrhythmia, none were improved. One patient with phenylketonuria and minor seizures was improved.It is concluded that this approach to anticonvulsant therapy is worth pursuing and that the drug may also find some use in the treatment of phenylketonuria and of seizures due to vitamin B(6) dependency.

Amino Acids↗