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Biomedical subjects

J A Tappin

Publications and source records attributed to J A Tappin.

7 recordsLinked to original sources
PubMed1995

Case report: multiple myeloma--a rare presentation.

An unusual case of multiple myeloma is reported in a 61-year-old man presenting with hepatomegaly and multiple hypoechoic lesions in the liver seen on ultrasound. Following cytotoxic chemotherapy the size and number of the lesions within the liver had significantly reduced.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1982

The plain abdominal radiograph in pseudomembranous colitis due to Clostridium difficile.

The plain abdominal radiographs have been reviewed in nine patients with proven pseudomembranous colitis. These demonstrated small intestinal dilatation in eight patients, colonic thumb-printing and haustral thickening in seven, ascites in five and colonic dilation in two cases. The elucidation of these signs, especially in combination, may suggest the diagnosis of pseudomembranous colitis in those at risk.

Aged↗
PubMed1981

Bronchial carcinoma presenting as autoimmune haemolytic anaemia.

A 68-year-old man presented with autoimmune haemolytic anaemia. Investigation revealed underlying bronchial carcinoma. A positive direct Coombs' test failed to revert to negative after removal of the primary tumour. This suggested the presence of metastases which was subsequently shown. The possible significance and origin of the autoantibody is discussed.

Aged↗
PubMed1979

Characterization and localization of human placental ferritin.

Ferritin has been purified from normal full-term human placentae and its antigenic and molecular characteristics compared with adult liver ferritin. Placental ferritin is composed predominantly of a single subunit type, co-migrating with a liver ferritin standard on sodium dodecyl sulphate/polyacrylamide-gel electrophoresis. Comparison of dose-response curves in an immunoradiometric assay indicated some tissue-specific antigenicity for placental ferritin. This was supported by immunofluorescence studies on cryostat sections of human placentae by using antibodies to placental and spleen ferritin. Specific staining for placental ferritin was demonstrated within placental syncytiotrophoblast, particularly localized towards the microvillus plasma membrane. Ferritin has also been shown by electrophoretic and antigenic analysis to be present in protein fractions solubilized from isolated human syncytiotrophoblast microvillus plasma-membrane preparations, suggesting that ferritin may play an active role in the transfer of iron from maternal transferrin across the syncytiotrophoblast plasma membrane.

Chemical Phenomena↗