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Biomedical subjects

J A Van Loo

Publications and source records attributed to J A Van Loo.

4 recordsLinked to original sources

The bifidogenic nature of chicory inulin and its hydrolysis products.

Research data on the bifidogenic effect of beta(2-1)fructans, which at present are commercialized in the U.S., Japan and Europe as food ingredients, are presented. These food ingredients originate from two different sources. Short-chain fructo-oligosaccharides are synthesized from sucrose and are composed of GFn [n beta(2-1) linked fructose moieties bound to a glucose molecule; 2 </= n </= 4]. The longer chain length molecule inulin is extracted with hot water from chicory roots (Cichorium intybus) and is also composed of GFn molecules (with 2 < n < 60). Oligofructose is a partial hydrolysate of inulin and is composed of GFn and Fm molecules (n and m indicate the number of fructose moieties with 2 </= n, m </= 7). All types of beta(2-1)fructans are well fermented by intestinal bacteria. For a given chain length, there is no difference in fermentation rate between GFn- and Fm-type beta-fructans. In vitro fermentation of inulin revealed that molecules with a chain length (degree of polymerization or DP) > 10 are fermented on average half as quickly as molecules with a DP < 10. All beta(2-1)fructans are bifidogenic and classified as biobiotics.

Bifidobacterium↗

Best's vitelliform macular dystrophy.

A patient with Best's vitelliform macular dystrophy in his right eye had an intact vitelliform disk and drusen of the optic papilla. Although the foveola elevated by a few tenths of a millimeter, resolution was only slightly affected and the retinal receptors remained remarkably well-aligned, suggesting that mechanisms subserving receptor alignment still functioned. Hue discrimination and visual acuity were only slightly affected and the electroretinogram and visually evoked response showed essentially normal values. The vitelliform disk in the left eye ruptured by direct, blunt trauma. This same eye later developed subretinal macular neovascularization, as its visual acuity reduced, retinal sensitivity decreased, receptor orientation showed abnormalities, and hue discrimination became less efficient; the electroretinogram and visually evoked response remained normal.

Accommodation, Ocular↗