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Biomedical subjects

J A van Oers

Publications and source records attributed to J A van Oers.

14 recordsLinked to original sources

Drinking patterns and health outcomes: occasional versus regular drinking.

AIMS: To compare the health of drinkers with different drinking patterns and particularly drinkers with comparable average intakes and different drinking frequency. SETTING: General population survey conduced in Eindhoven, the Netherlands (n = 18,973). MEASUREMENTS: Chronic conditions, perceived general health, and health complaints were the outcome measures. Drinking categories were constructed by taking into account the frequency and amount of alcohol consumption (up to six glasses per sitting). FINDINGS: Drinking 3-5 days per week/3-5 glasses per occasion and drinking 6-7 days/1-2 glasses were associated with lower likelihood for reporting health complaints and for perceiving one's health as less than good compared to those drinking 1-2 days/1-2 glasses (reference group). Drinking 1-2 days/6 glasses was associated with being more likely to report chronic conditions, compared to the reference group. Those drinking 1-2 days/6 glasses were significantly more likely to report > 3 health complaints than those drinking 6-7 days/1-2 glasses. Although no differences were observed for any of the other comparison groups, at high levels of consumption (18-35 units/week), occasional drinkers (3-5 days/6 glasses) seemed to have better health outcomes compared to their counterparts (6-7 days/3-5 glasses). CONCLUSION: In addition to average alcohol intake, drinking pattern is also related to health.

Adolescent↗

Adverse working conditions and alcohol use in men and women.

OBJECTIVE: This study examined the association between adverse working conditions and abstinence and heavy drinking. METHODS: The study was a cross-sectional study within the framework of a general population survey conducted in Eindhoven, The Netherlands (N = 7533). Working conditions were classified into four domains: hazardous physical working conditions, demands at work, level of control over one's job, and support from coworkers and supervisors. Abstainers were compared with drinkers; within drinkers, heavy drinkers were compared with light-moderate drinkers, and those who reported binge drinking were compared with those who did not report binge drinking. RESULTS: Respondents who reported adverse working conditions were as likely to be abstainers as they were to be drinkers. Within drinkers, males and females who reported high hazardous physical working conditions were more likely to be heavy drinkers than to be light-moderate drinkers (light-moderate is not just an amount, but a combination of amount and frequency) and to report binge drinking (males only). Respondents who reported high demands were also more likely to be heavy drinkers than to be light-moderate drinkers. CONCLUSIONS: Stressful circumstances, such as adverse working conditions, were associated with high levels of alcohol intake among drinking men and women.

Aged↗

[The role of allergy in interstitial cystitis].

In two women, aged 47 and 58 years, who suffered from longstanding urinary bladder complaints, various urologic treatments had been carried out, which however had had only a partial therapeutic effect. They also suffered from allergic rhinitis and multiple arthralgia. Allergologic investigations including nasal challenges with inhalant allergens and food ingestion challenges revealed the causative participation of the inhalant allergens and the food components in the urinary complaints. The all-round allergologic management, including dietary measures, avoidance of the relevant allergens and nasal as well as oral administration of disodium cromoglycate therapy, led to the almost complete disappearance of the urinary and other complaints. Interstitial cystitis is a regularly appearing urinary disorder, especially in female patients. In practice, the possible causative role of allergy and especially of food allergy is only rarely included in the differential diagnosis of this disorder.

Anti-Asthmatic Agents↗

The U-shaped curve: various health measures and alcohol drinking patterns.

OBJECTIVE: To determine whether the well-known U-shaped relationship between average alcohol intake and mortality also holds for other health measures and for aspects of drinking other than weekly average alcohol intake, such as frequency of heavy-drinking episodes. METHOD: This study was carried out within the framework of a general population survey conducted in Eindhoven, The Netherlands (N = 18,973). Apart from mortality, the following health measures were considered: self-assessed health (based on perceived general health and the Nottingham Health Profile questionnaire), a list of chronic conditions and a list of health complaints. Respondents were categorized as abstainers, light (1-14 units/week), moderate (15-28 units/week) and excessive drinkers (> or =29 units/week). Information on the frequency with which heavy-drinking episodes occurred was also available. RESULTS: Light or moderate drinkers had not only lower mortality but other health burdens were lower than for either abstainers or heavier drinkers. Frequent heavy-drinking episodes were observed to be directly related to increased mortality rates, although not significantly. A trend was observed for drinkers reporting seldom heavy-drinking episodes (once or twice in the previous 6 months) to report less health burdens and to have lower mortality rates than those reporting no heavy drinking episodes. CONCLUSIONS: A U-shaped pattern was observed for mortality as well as for several other health measures. Frequent heavy-drinking episodes were related to an increased likelihood of mortality (not significant but suggesting a J-shaped pattern) and were not related to other health measures.

Adolescent↗

Comparing the diagnostic accuracy of carbohydrate-deficient transferrin, gamma-glutamyltransferase, and mean cell volume in a general practice population.

In certain populations, the biological alcohol marker carbohydrate-deficient transferrin (CDT) is known to have a high diagnostic accuracy. The aim of this study was to compare the diagnostic accuracy of CDT, gamma-glutamyltransferase (gamma-GT), and mean cell volume (MCV) in a general practice population; more specifically, to ascertain whether CDT is a better tool than gamma-GT and MCV for (early) recognition of excessive alcohol use. To represent the general practice situation as realistically as possible, three different drinking patterns are defined: irregular excessive, regular excessive, and very excessive. From a sample of 524 men from seven general practices, sensitivity, specificity, and predictive values of the three markers for the three drinking patterns were compared, and receiver-operating characteristic analysis was used to compare differences between the markers. The results indicate that drinking patterns do influence the (difference in) diagnostic accuracy. CDT has a higher diagnostic accuracy for all three drinking patterns than gamma-GT and higher predictive values for hazardous [(ir)regular excessive] drinking patterns than MCV. However, receiver-operating characteristic analyses failed to demonstrate a significant difference between these patterns. It is concluded that the performance of all tests is too low to be useful for screening procedures in a general population; however, some tests may be useful for case finding. CDT seems to be the best alcohol marker available, although the difference between CDT and MCV is small.

Adolescent↗

Gender differences in alcohol-related problems: controlling for drinking behaviour.

AIMS: Two hypotheses were tested to explain a high prevalence of alcohol-related problems among women relative to their low prevalence of excessive drinking: (1) At a given level of drinking, women may report more problems of any type than do men. (2) At a given level of drinking, the number of problems or the severity of the reported problems may be lower among women than among men. DESIGN: General population survey. SETTING: Rotterdam, The Netherlands. PARTICIPANTS: 3537 Dutch respondents within the age range 16-69 years. MEASUREMENTS: Alcohol-related problems were measured in five problem areas: psychological dependence, symptomatic drinking, social problems, health problems/accidents and frequent drunkenness/hangovers. A problem index was formed by adding up the scores in the five separate problem areas. Alcohol use was measured by the Quantity-Frequency-Variability index. FINDINGS: For the same level of drinking, women were as likely as men to report alcohol-related problems except that women light drinkers were actually less likely to report problems than men. Men tended to have a greater accumulation of different types of problems within drinking categories than women. Overall problem severity, however, did not differ between men and women. The apparent excess prevalence of alcohol problems in women relative to drinking level appears to be due to presence of problems even among light drinkers and a greater preponderance of light drinkers in women than men. CONCLUSIONS: The first hypothesis was rejected; drinking levels being the same, the level of alcohol problems is the same or even lower for women than for men. As hypothesized, men tend to have a greater accumulation of different kinds of problems than women. However, the severity of the reported problems does not differ between men and women.

Adolescent↗

The specificity of the CDT assay in general practice: the influence of common chronic diseases and medication on the serum CDT concentration.

Early recognition of alcohol problems by general practitioners might be enhanced by the use of better alcohol markers. Several studies have revealed promising results for the carbohydrate-deficient transferrin (CDT) assay in certain populations. The aim of our study was to examine the specificity of the CDT assay in a general practice population. The main research question was whether common chronic diseases and/or the accompanying prescribed drugs have a negative influence on the specificity of the CDT assay. The 524 men who participated were selected from seven general practices and were suffering from one or more of the following diseases: hypertension, asthma/bronchitis, diabetes mellitus, adipositis/lipid metabolism disorder, angina pectoris, depression, and disorders of the digestive tract. None of the studied diseases or of the accompanying prescribed drugs had an influence on the specificity of the CDT assay. The overall specificity in this general practitioner population was 0.92. It can be concluded that the studied diseases do not bear an influence on the serum CDT concentration, and that, therefore, the CDT assay is a highly specific instrument for use in assessing alcohol consumption in general practice patients.

Adult↗

A research perspective on drug related nuisance--Dutch experiences.

The Dutch policy on drugs has yielded positive results from the public health point of view. Drug related nuisance, however, is an enduring problem and society's acceptance of this nuisance is diminishing. This article discusses the concept of drug-related nuisance and addresses the question how this nuisance can be measured. Next to it, attention is paid to the question whether the so-called Dutch "harm reduction policy" will survive.

Crime↗

The geographic relationship between alcohol use, bars, liquor shops and traffic injuries in Rotterdam.

Within the scope of the World Health Organization's program "Health for All by the Year 2000," a health information system for Rotterdam neighborhoods was developed. Through this information system, among others, data on geographic distribution of alcohol use, bars, liquor shops and traffic accidents are collected. Research has been done on the geographic relationship between the percentage of alcohol users and numbers of bars, liquor shops and traffic injuries. Significant correlations were found between the percentage of alcohol users and traffic injuries per neighborhood, the number of bars and traffic injuries per neighborhood and the percentage of alcohol users and number of liquor shops per neighborhood. Although confounding of the data occurs, the observed relations can be logically explained. Knowledge of the geographic relation between alcohol use, traffic injuries and number of bars can be useful for further development of multi-sectoral health policies.

Accidents, Traffic↗

Quantitative indicators for a healthy city--the Rotterdam local health information system.

STUDY OBJECTIVE: The aim was to develop a local health information system for monitoring health status and for contributing to the development of local health policy. DESIGN: At district or even at neighbourhood level, data are collected on health status and factors related to health, including lifestyle, social and physical and environment, and the health care system. Data are collected from central and municipal Bureaus of Statistics, health care services, regional and municipal institutions, and by means of regularly performed local health surveys. SETTING: The 84 neighbourhoods of the Rotterdam Municipality. MAIN RESULTS: In the local health information system three sorts of data are collected: data on health status, data on health risk factors, and socioeconomic and demographic data. Two examples of data on health status are given (mortality and mental health) which were analysed. These data show differences in health status between several districts in Rotterdam, which can be related to differences in socioeconomic status between these districts. Examples are given of the influence of the project on local health policy in Rotterdam. CONCLUSIONS: The main conclusion is that the local health information system has great promise as an information system to give direction to local health policy. However if this promise is to be fulfilled, it will be necessary to obtain data from more varied sources.

Female↗

Alcohol consumption, alcohol-related problems, problem drinking, and socioeconomic status.

In general, a lower socioeconomic status (SES) is related to a lower health status, more health problems, and a shorter life expectancy. Although causal relations between SES and health are unclear, lifestyle factors play an intermediate role. The purpose of the present study was to obtain more insight into the relation between SES, alcohol consumption, alcohol-related problems, and problem drinking, through a general population survey among 8000 people in Rotterdam. Odds ratios were calculated using educational level as independent, and alcohol consumption, alcohol-related problems, and problem drinking as dependent variables. Abstinence decreased significantly by increasing educational level for both sexes. For men, excessive drinking, and notably very excessive drinking, was more prevalent in the lowest educational group. For women, no significant relation between educational level and prevalence of excessive drinking was found. After controlling for differences in drinking behaviour, among men the prevalence of 'psychological dependence' and 'social problems' was higher in intermediate educational groups, whereas prevalence of 'drunkenness' was lower in intermediate educational groups. For women, a negative relation was found between educational level and 'psychological dependence'; prevalence of 'symptomatic drinking' was higher in the lowest educational group. Prevalence of problem drinking was not related to educational level in either sex. It is concluded that differences exist between educational levels with respect to abstinence, but only limited differences were found with respect to excessive drinking. Furthermore, there is evidence for higher prevalences of alcohol-related problems in lower educational levels, after controlling for differences in drinking behaviour, in both sexes.

Adolescent↗

The development of alcohol consumption and problem drinking in Rotterdam 1980-1994: more problem drinking amongst the young and the middle aged.

In 1980/1981 and in 1994, two surveys on problem drinking were conducted in the city of Rotterdam. This article presents data on changes in alcohol consumption and alcohol-related problems between 1981 and 1994. Special attention has been paid to possible shifts in groups at risk and to shifts in the kind of problems experienced. It was found that, in 1994, compared to 1981, problem drinking had become more prevalent amongst the young and the middle aged.

Adolescent↗