Biomedical subjects

J Abdulkadir

Publications and source records attributed to J Abdulkadir.

At least 19 recordsLinked to original sources

PubMed1992

Relative contribution of HLA-DQA and -DQB alleles to predisposition to insulin-dependent diabetes mellitus.

The presence of DQA and DQB alleles conferring protection or susceptibility was assessed in a panel of 39 insulin-dependent diabetes mellitus patients and 39 healthy control subjects from the central highland of Ethiopia. The results were grouped into three entities: a combination of alleles conferring susceptibility, a group conferring protection, and a group without any apparent HLA-DQ or -DR predisposition to insulin-dependent (type 1) diabetes mellitus (IDDM). Statistical analysis revealed that the relative risk of the first group is 64.1. If a similar approach is applied to the data on a study in caucasoid IDDM patients and controls of Kahlil and colleagues, the pattern is fully consistent with the data presented here, with an extraordinarily high relative risk (RR 258.2). It will be of interest to study whether this subdivision is reflected or supported by clinical or etiologic differences of the disease. The predictive value of susceptibility phenotypes appears to be more accurate by the proposed subdivision. Furthermore, in combination with islet-cell antibody analysis, assessment of genotype will permit more accurate identification of prediabetic individuals to be entered in clinical trials.

Alleles↗

PubMed1992

A study of the transfer of insulin-requiring diabetic patients from U-40 to U-100 Lente insulin.

A pilot study of the transfer of insulin-requiring diabetic patients from U-40 to U-100 Lente insulin was conducted in 16 patients. The patients were returned to U-40 after 12 weeks on U-100. There were no adverse events specifically attributable to the process of transfer. The mean blood glucose values for the last day and the last 2 days on U-100 insulin (154.58 +/- 32.09 mg% and 152.99 +/- 29.23 mg% respectively) were significantly lower than those for the corresponding periods on U-40 insulin (178.06 +/- 38.48 mg% and 169.83 +/- 32.34 mg% respectively), (t = 2.79, p = 0.014 and t = 2.30, p = 0.036 respectively). But there was no significant difference between the mean values for the last but one day on U-40 and U-100 (152.36 +/- 27.81 vs 161.59 +/- 33.82; t = 1.16, p = 0.264). There was no significant increase in frequency (2.3 episodes per week on U40 versus 2.8 episodes per week on U-100) or severity of hypoglycaemic attacks with U-100 insulin. On the basis of this experience we feel that transfer from U-40 to U-100 insulin can be achieved without risk of serious adverse consequences provided the transfer is carried out according to a well-designed plan of action.

Adult↗

PubMed1990

The clinical and hormonal (C-peptide and glucagon) profile and liability to ketoacidosis during nutritional rehabilitation in Ethiopian patients with malnutrition-related diabetes mellitus.

Cases of malnutrition-related diabetes mellitus conforming to the description of the protein deficient pancreatic diabetes type in Ethiopian patients were compared with Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetic. Fourteen of 39 malnutrition-related diabetes mellitus patients had fat malabsorption compared with only two of ten Type 1 diabetic patients and one of nine control subjects. Xylose absorption was normal favouring a pancreatic cause for the malabsorption. Plasma C-peptide during oral glucose tolerance test was significantly lower than that in Type 2 diabetic patients and normal control subjects (p less than 0.01 to 0.001) and was also consistently but not significantly higher than in Type 1 diabetic patients. Glucagon secretion patterns were similar in malnutrition-related and Type 1 diabetic patients. Of 23 new malnutrition-related diabetic patients treated with glibenclamide after nutritional rehabilitation and insulin treatment, only three responded, 14 were unresponsive but remained ketosis free for over eight days while another six developed ketoacidosis or significant ketonuria within two to six days during the trial. Sixteen unselected Type 1 diabetic patients who discontinued their insulin therapy all developed frank ketoacidosis after a mean of 5.5 days. The similarity of the malnutrition-related and Type 1 diabetes mellitus in age of onset, insulin requirement for diabetic control and appearance of ketosis-proneness in some cases, together with the similarity of C-peptide and glucagon secretion patterns suggest that the protein deficient pancreatic diabetes variant of malnutrition-related diabetes mellitus may be Type 1 diabetes mellitus modified by the background of malnutrition rather than an aetiologically separate entity.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

PubMed1990

Normal thyroid function values in Ethiopians.

Thyroid function values were determined in 56 healthy nongoitrous adult Ethiopians. The mean triiodothyronine (T3) values for 20 males and 36 females were 1.42 +/- 0.32 nmol/L and 1.51 +/- 0.25 nmol/L, and thyroxine (T4) values were 119 22 nmol/L and 116 +/- 21 nmol/L respectively. The mean thyrotropin (TSH) values for males and females were identical at 1.85 +/- 0.94 mu/L. Radioactive iodine uptake (RAIU) at 2 hours was 8.6 +/- 4.4% in males and 11.3 +/- 4.3% in females, and at 24 hours 31.7 +/- 11.7% and 38.9 +/- 11.1% respectively. The differences between males and females were significant at both 2 and 24 hours (P less than 0.05). The ranges for the 3 hormones derived from the mean 2SD values are close to those supplied with the kits but the Ethiopian RAIU values are higher than the values currently applicable in developed countries, probably indicative of the lower level of dietary iodine available to the population here. The values obtained in this study are offered to serve as normal reference for the interpretation of thyroid function results in Ethiopian patients. A strategy for the rational utilization of the available in vivo [corrected] tests is suggested.

Adolescent↗

PubMed1990

Study of family history among parents and siblings of Ethiopian diabetics: a preliminary report.

218 diabetic probands and 300 non-diabetic controls were interviewed for history of diabetes mellitus in their parents and siblings. The prevalence of diabetes mellitus among blood relatives of probands and controls differed significantly. The study also showed that NIDDM probands had more positive family history of diabetes than IDDM ones. The overall findings of this study indicated that heredity has an important role in the genesis of diabetes mellitus in Ethiopian diabetics.

Adolescent↗

PubMed1989

HLA-DR and -DQ antigens in malnutrition-related diabetes mellitus in Ethiopians: a clue to its etiology?

Thirty Ethiopian malnutrition-related diabetes mellitus (MRDM) patients were HLA typed and their HLA antigen frequencies were compared to those of 31 previously typed insulin-dependent diabetes mellitus (IDDM) patients and to 84 controls from the same ethnic background. In comparison to controls, a striking association between MRDM and HLA-DR3 (X2 = 15.15, p = 0.0001) was observed, whereas the frequency of HLA-DR4 was non-significantly increased (RR = 1.72). The frequency of DR2, DQw1, and DQw6 was decreased among MRDM. In comparison to IDDM that is associated with both DR3 and DR4 in this population, MRDM showed no significant differences in HLA class II antigens frequencies. Therefore, the genetic basis of susceptibility to MRDM and IDMM in Ethiopia is at least partially identical.

Diabetes Mellitus↗

PubMed1989

Light and electron microscopic changes in sural nerves in Ethiopian diabetics.

The light and electron microscopic morphological changes in sural nerve biopsies from 32 Ethiopian diabetics and 4 malnourished non-diabetic subjects were studied in order to determine the role of malnutrition in the development of diabetic neuropathy. The most prominent finding in diabetics with clinical neuropathy was reduction in the density of myelinated axons of all diameters especially the large ones. Affected nerves showed abundant intraneural collagen, and evidence of nerve regeneration in some cases. Demyelination, though present, was less marked. Changes in the vasa nervorum were seen in only one case. The morphological changes correlated with the duration and severity of the diabetes and with nerve conduction velocity. No changes were seen in malnourished non-diabetics and diabetics without clinical neuropathy, thus suggesting that malnutrition by itself does not contribute significantly to the development of diabetic neuropathy. Axonal degeneration appears to be the predominant feature in diabetic neuropathy.

Adolescent↗

PubMed1985

Limited finger joint mobility in insulin-dependent and non-insulin-dependent Ethiopian diabetics.

The prevalence of limited joint mobility (LJM) was studied in 110 insulin-dependent (IDDM) and 190 non-insulin-dependent (NIDDM) consecutive Ethiopian African diabetics and 300 age- and sex-matched controls at the Tikur Anbassa Teaching Hospital in Addis Ababa over a period of 18 months. Mean ages +/- S.D. of the IDDM, NIDDM, and controls were 35 +/- 9.9, 49.4 +/- 12.0, and 43.3 +/- 14.0 years, respectively. LJM was found in 44.5% of IDDM, 25.3% of NIDDM, and 6.7% of controls, being significantly commoner in IDDM than NIDDM (p less than 0.001) and in the diabetics than in controls (p less than 0.001). In IDDM those with LJM were significantly younger (p less than 0.05), had a higher prevalence of median fasting blood glucose (FBG) levels of 15 mmol/l and above (p less than 0.01), and retinopathy (p less than 0.05), but did not differ from those without LJM in duration of diabetes, or prevalence of neuropathy and nephropathy. In NIDDM those with LJM had a significantly longer duration of diabetes (p less than 0.005) and a higher prevalence of nephropathy (p less than 0.005), but did not differ from those without LJM in age at onset of diabetes, prevalence of neuropathy, and retinopathy or median FBG level.

Adolescent↗

PubMed1979