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J Adamczyk

Publications and source records attributed to J Adamczyk.

17 recordsLinked to original sources
PubMed1985

Lithium effects on ophthalmological-electrophysiological parameters in young healthy volunteers.

The effects of lithium on the visual system in man have been tested. Ten healthy volunteers followed a 10-day lithium regimen. Lithium plasma levels in the range of 0.6-0.8 mmol/l were obtained. Clinically used ophthalmological-electrophysiological tests were performed. Most of the tests showed no significant change during the lithium treatment. The lithium regimen resulted in a strong reduction of the slow phase. Also the "Arden-ratio", measured by electrooculogram (EOG), was influenced by lithium. The "Arden-ratio" reflects the corneo-fundal potential in retinal illumination and dark adaptation and is influenced by the state of adaptation. All the demonstrated effects were fully reversible at the end of lithium administration. Possible mechanisms of the action of lithium are discussed (for example Ca2+-fluxes, c-AMP, cGMP). These lithium-induced effects on the visual system in man may give some hint of the individual responsiveness to lithium.

Adult↗
PubMed1979

Partial purification and characterization of the oxytocin-inactivating enzymes from chicken liver.

1. Two enzymes acting on the linear portion of oxytocin: carboxamidopeptidase (releasing Gly . NH2) and prolyl peptidase (releasing Leu-Gly . NH2) were identified in the cytoplasmic fraction of chicken liver. 2. Carboxamidopeptidase was purified 134-fold with a 23% yield, and prolyl peptiase 71-fold with a 20% yield. The specific activity of the final preparations was 181 and 96 microU/mg protein, respectively. 3. The optimum pH for carboxamidopeptidase was 6.0--6.5 and for prolyl peptidase, 7.5. Carboxamidopeptidase activity was inhibited by Mn2+, Zn2+, Ca2+, Co2+, and stimulated by EDTA; the activity of prolyl peptidase was inhibited by Zn2+ and Mn2+. The Km value of both enzymes for oxytocin was 1.5--2.4 microM.

Animals↗