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Biomedical subjects

J Aguilera

Publications and source records attributed to J Aguilera.

45 records · Page 3Linked to original sources
PubMed1980

[Vitamin A and cancer (author's transl)].

During the past decade, an increasing number of publications have been dealing with the experimental and clinical activity of vitamin A on epithelial neoplasms. Many studies suggest that vitamin A and its analogs may be able to interfere with chemical carcinogenesis and to modify favorably the immune status of tumor bearers by mechanisms incompletely known. The use of vitamin A and of its analogs have been shown to enhance the effects of surgery, radiation therapy and chemotherapy in the treatment of epithelial cancer, possibly because they appear to destabilize lysosomal membranes and contribute to maintenance of the differenciated state in epithelial tissues. The potential role of such substances in preventing neoplastic transformation deserves further study.

Animals↗
PubMed1979

Phase I trial with peptichemio.

Thirty-two patients with tumor progression, even after conventional cytostatic drug treatment, were treated with peptichemio, with increasing doses for groups of 4 patients. The maximum tolerated dose (with minimum hematological toxicity and without any other evident toxicity) with repeated administrations, was 1.2 mg/kg twice weekly. The recommended doses for phase II trials are, as shown by the detailed analysis of the results, 0.9 mg/kg, twice weekly and administered alone, and 1.3 mg/kg, once weekly combined with other cytostatic drugs, in 500 ml of infusion fluid, with 25 mg of heparin and 25 mg of hydrocortisone to minimize the freqent risk of local phlebosclerosis.

Adult↗
PubMedDate not supplied

Epidemiological investigation of Taenia solium taeniasis and cysticercosis in a rural village of Michoacan state, Mexico.

We performed a survey for taeniasis and cysticercosis among persons living in a Mexican village where Taenia solium infection in pigs was known to be enzootic. A standardized questionnaire was administered in all 577 households to obtain medical histories and information on demographic and environmental factors and on risk factors associated with transmission of infection. Serum and/or stool specimens were obtained from 1005 volunteers and examined for cysticercosis antibodies and intestinal parasites. Faecal examination of 828 participants revealed infection by Taenia sp. in 2 (0.2%). Three additional cases of taeniasis were detected in individuals who evacuated proglottids after treatment with praziquantel. Of 1005 human serum specimens, 49 (4.9%) were positive in the cysticercosis immunoblot assay. Seropositivity increased with age and reached a peak in subjects aged 46-55 years (P < 0.05). A history of seizures was significantly associated with seropositivity (P < 0.05); approximately 25% of persons with such histories were seropositive. Histories of headache, dizziness, trembling, blurred vision, and vomiting were also significantly associated with positive immunoblot assays. This study has demonstrated previously undiagnosed morbidity associated with T. solium neurocysticercosis and identified community behavioural and environmental practices that must be modified to prevent continued transmission of cysticercosis and taeniasis.

Adolescent↗
PubMedDate not supplied

[Use of a double-lumen tube with intermittent positive ventilation in a case of distal tracheal laceration].

We discuss the management of anesthesia in a patient brought to hospital following a traffic accident in which she suffered distal laceration of the trachea and unstable vertebral fracture that met surgical criteria. Our main objectives were to avoid placing positive pressure on the damaged trachea and to extubate immediately after surgery. Using a left double-lumen endotracheal tube guided by flexible bronchoscope, we administered general anesthesia with mechanical ventilation and positive pressure, with no air leakage through the damaged area. Anesthesia was maintained by continuous perfusion of propofol, allowing good hemodynamic stability and rapid extubation. We conclude that this will be a useful procedure in similar cases when no other form of mechanical ventilation is available.

Adult↗