Biomedical subjects
Publications and source records attributed to J Agut.
In this work, the bioavailability of the 14C-methyl-labelled cytidine diphosphate choline (CDP-Choline, citicoline, Somazina), has been studied by oral route, leading to the result that it is slowly and completely absorbed, with a very low urinary and fecal elimination, thus producing maintained blood levels. The bioavailability related to oral route compared with intravenous route is practically the same.
Oral administration of 14C methyl CDP-choline in Sprague-Dawley rats provided the following data: --Radioactivity from cytidine diphosphate choline (CDP-choline, citicoline, Somazina) is found in the brain at a high rate. --62.8% of total radioactivity measured in the brain is found as a part of phospholipids. --This radioactivity is detected by the labelling of phosphatidyl-choline and endogenous sphingomyelin from CDP-choline. This suggests that CDP-choline by oral administration has effects on the synthesis of basic phospholipids being essential for the structure and function of the cellular membrane.