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Biomedical subjects

J Alexiou

Publications and source records attributed to J Alexiou.

5 recordsLinked to original sources
PubMed1999

Development of a desmoid tumor at the site of a total hip replacement.

Extra-abdominal desmoid tumors are locally aggressive benign soft tissue tumors arising from the connective tissue of muscle and overlying fascia or aponeuroses. Location around the hip occurs in about 10% of all desmoid tumors. The authors report the development of a desmoid tumor around the hip 45 months after implantation of a total hip prosthesis. Endocrine and physical factors seem to play an important role in the development of the disease. Moreover, an association has been reported between trauma and desmoid tumor. Desmoid tumors developing around silicon implants have also been described. However, no association between hip prostheses and desmoid tumors has been published in the world literature. Although soft tissue tumors induced by metallic implants have been observed clinically, we still seek a coherent explanation for the exact pathogenesis.

Aged↗
PubMed1998

Intramuscular myxoma.

Intramuscular myxoma is a rare, benign, mesenchymal tumour. It contains fibroblast-like, histiocyt-like and myofibroblast-like cells in a myxoid material. These tumours occur in adults between 40 and 60 years with a predilection for women (70%). The incidence varies between 0.10 and 0.13/100.000. They may occur as an independent lesion or in conjunction with fibrous dysplasia or Albright syndrome. Although only circumstantial features have linked fibrous dysplasia and myxoma, the concept of a basic metabolic error of both tissues during initial growth period has been proposed. There are no specific clinical manifestations of this tumour. Although MRI offers the best imaging approach in terms of determination of the local extension of the tumour and its fatty texture, the differential diagnosis between intramuscular myxoma and myxoid degenerescence of a liposarcoma must be considered. The diagnosis is always made after microscopic examination. Local excision with histological margins free of tumour provides excellent local control without recurrence. The case of a patient presenting this rare tumour is presented. A thorough survey of the literature was done.

Diagnosis, Differential↗
PubMed1998

Camurati-Engelmann disease. Effects of corticosteroids.

Camurati-Engelmann disease is an uncommon condition, radiologically characterized by symmetric diaphyseal sclerosis involving the tubular bones. Clinical features include limb pain, muscle weakness, waddling gait and sometimes deafness. The evaluation is made by conjunction of radiographic and scintigraphic data. Corticosteroids and analgesics improve the quality of life, decrease the pain but do not alter the course of the disease. The evolution is unpredictable. The history of a 23 year old male with such a disorder is presented hereafter. His clinical course shows a very good response to the administration of corticosteroids, whereas no improvement is observed as far as the radiographic and isotopic features are concerned.

Adult↗
PubMed1991

Post-myelographic meningeal irritation with iohexol.

A 45-year-old woman developed signs of meningeal irritation after myelography with iohexol. Her condition improved very quickly (after antibiotic treatment). Rapid improvement, absence of pathogenic organisms in the pre-treatment CSF culture, the level of CSF pleocytosis and protein were in favor of chemical meningitis.

Diagnosis, Differential↗