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Biomedical subjects

J Amiel

Publications and source records attributed to J Amiel.

At least 127 records · Page 7Linked to original sources
PubMed1988

[Initial treatment of infiltrating tumors of the bladder. Combined transurethral resection and systemic chemotherapy].

From September 1983 to September 1986, 20 patients (mean age 65 years) with a muscle-infiltrating tumour of the bladder would normally have been treated by total cystectomy. Instead, they were staged by intravenous urography, pelvic and abdominal computerized tomography, physical examination under general anaesthesia and deep transurethral resection, then given neoadjuvant chemotherapy consisting of cisplatinum and 5-fluorouracil, six courses at intervals of 28 days. Results were evaluated after the 3rd and 6th courses by computerized tomography, intravenous pyelography and transurethral resection. Nine patients had a clinical complete response (6 pT2, 2 pT3, 1 pT4). The median follow-up in january, 1988 was 30 months (range 17-52 months). This protocol was objectively active and well tolerated, even by elderly subjects. Two problems remain concerning patients with complete response: the respective roles of chemotherapy and transurethral resection in the outcome, and the prevention of recurrence (5/9 complete response patients).

Adult↗
PubMed1988

Anandron (RU 23908) associated with orchiectomy in stage D prostate cancer. Preliminary results of a randomized, double-blind study.

A randomized, double-blind, multicenter trial was performed comparing the association of orchiectomy plus the nonsteroid antiandrogen Anandron (300 mg daily) to orchiectomy plus placebo in the treatment of patients with stage C or D prostate cancer. The results for 98 evaluable stage D patients with a median follow-up of 23.4 +/- 8.9 months are given. Although there was no statistically significant difference between the two treatments with regard to any parameter (subjective response, best objective response according to NPCP criteria, and progression-free interval and survival), the results were invariably in favor of the combined treatment, as already reported in other trials on Anandron.

Aged↗
PubMed1988

[1987: the 100th anniversary of transvesical prostatic adenomectomy].

The present study is an attempt to outline the views held with the passage of time on the pathology of prostatic hypertrophy and upon the numerous palliative operations that have been used. As a natural limit, the author close to end the investigation at the beginning of the 20th century, when the principles of radical therapy were defined and accepted. It is demonstrated that a similar limit applies to the question of pathology, as the role of periurethral glands the ffue seat of prostatic hypertrophy was not definitely worked until the studies of Albarran (1900), Motz and Pérearnau (1905).

Europe↗
PubMed1988

[Role of Chlamydia trachomatis in male urethritis. Analysis of 2,000 cases of male urethritis].

A study involving of 2,000 cases of urethritis revealed the presence of Chlamydia trachomatis in 44% of patients. Following a pathophysiological review, the strongly suggestive clinical picture of infection by this microorganism is emphasized. This study stresses two precise points by dealing with: firstly, the importance of the choice of technique for demonstration of the presence of the bacteria, and its reliability; secondly, the value of bacteriological evidence of the infection in order to treat not only the patient but also the partner(s) and to subsequently confirm the treatment as being effective.

Adult↗
PubMed1988

[Combination transurethral resection and systematic chemotherapy as primary treatment of infiltrating bladder tumors (pT2-pT4 NxM0)].

From Sept. 83 to Sept. 86, 20 patients (pts), mean age 65 yr, with a muscle-infiltrating bladder tumor would normally have been treated by total cystectomy. Pts were staged by intravenous urography, pelvic and abdominal CT, physical examination under general anesthesia, and deep TUR, then given neoadjuvant chemotherapy: cisplatinum and 5-FU. Courses were given every 28 days. Results were evaluated after the 3rd and 6th courses by CT, IVP and TUR. 9 pts had a histologically confirmed complete clinical response (pCR: 6 pT2, 2 pT3, 1 pT4). Median follow-up in Jan. 1988 was 30 mo. (17-52). This protocol was objectively active and well tolerated, even by elderly pts. Problems remain concerning pCR pts: (1) the respective roles of chemotherapy and TUR on the outcome; (2) prevention of recurrence (5/9 pCR).

Adult↗
PubMed1987

Islet cell transplantation: important factors contributing to optimal pancreatic function.

This study investigates four factors which are of utmost importance in contributing to optimal function of pancreatic tissue fragment allotransplants. Those being: viability of donor tissue, optimal weight of pancreatic tissue fragments, method of allograft preparation, and site of implantation. Seven groups of unrelated mongrel dogs underwent total pancreatectomy before being randomly assigned to one of the following experimental groups. Group I (n = 10) animals were transplanted with greater than 0.75 g/kg of viable, pancreatic tissue fragments, whereas those in Group II (n = 6) received less than 0.75 g/kg of nonviable pancreatic pieces. In both groups, the donor pancreases were processed without collagenase, before being injected into the renal subcapsular space. Mean survival among Group I animals was 43 +/- 17 days (M +/- SD), while dogs in Group II survived a mean of 2.6 +/- 0.9 days (M +/- SD). Dogs in Group III (n = 5) were injected in the supracapsular peritoneum with greater than 0.75 g/kg of viable, collagenase-free pancreatic tissue fragments, and mean survival was noted to be 3.1 +/- 1.2 days (M +/- SD). Recipients in Group IV (n = 5) received greater than 0.75 g/kg of nonviable pancreatic tissue pieces prepared without collagenase in the renal subcapsular space, resulting in a mean survival of 2.8 +/- 0.9 days (M +/- SD). Group V (n = 6) animals survived a mean of 20 +/- 18 days (M +/- SD) when transplanted with greater than 0.75 g/kg of viable pancreatic tissue fragments prepared with collagenase, in the renal subcapsular space.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1987

[Value of urinary time in bone scintigraphy in the evaluation of renal function. Apropos of 57 cases of cancer of the prostate].

Intravenous urography (IVU) and bone scintiscan imaging (BSI) are essential investigations during initial evaluation of prostate cancer. A study compared data provided by these two exploratory procedures in evaluation of renal function. Concordance was high (86%) between IVU and urinary images during BSI. The latter examination is non-invasive and has no contraindications. It produces indispensable oncologic information in patients with cancer of prostate and a result of the urinary secretion phase can avoid repetition of IVU during follow up.

Bone and Bones↗
PubMed1987

[Gangrenous states of the perineum and genital region].

The authors report on 13 cases of gangrene of the perineum. Eight of the patients presented with a pre-existing infectious or tumoral anorectal lesion. In two cases, gangrene was a complication of a surgically treated prostatic pathology; two other patients had Fournier's disease. The last case was termed "spontaneous" as no causative factor was found. The unexpected recrudescence of this pathology, its severe nature, our limited knowledge of the pathogenic factors involved, and the difficulties encountered in treatment make analysis of this series of cases particularly interesting; moreover, despite the apparent etiological disparity of these observations, there were common anatomic, bacteriologic, and therapeutic elements. As concerns treatment, emphasis is placed on three points: prime role of surgery, the only means of obtaining precise information on lesions, broad indications for bypass colostomy, value of treatment with hyperbaric oxygen. The mortality rate remains high: 4 of the 13 patients died.

Adult↗
PubMed1982

Correlation between cytology and cystoscopy in the follow-up of patients with bladder tumours.

The correlation between cytology and cystoscopy was established using data from 450 cytologic and cystoscopic examinations performed on 401 urology outpatients. Cytology specimens were interpreted by cytopathologists, without access to any clinical information. 311 examinations were performed on patients with present or past bladder tumour history and 139 on patients who were examined for other urological causes. Cytology specificity was good, with a low rate of false-positive results, and revealed 36% of cystoscopically visible tumors; sensitivity increased with tumour grade. In some patients, positive cytology preceded the appearance of tumoral lesions by several months. Cytology and cystoscopy are complementary methods for use in the management of patients with bladder tumours.

Cystoscopy↗
PubMed1980

[Study of 39 T1-T2 cervical stump cancers treated by a radio-surgical procedure (author's transl)].

The authors present a casuistic study of 39 cervical stump cancers treated by combined radio-surgery at the Cancer Center in Nice. The protocol is similar to that of the uterine cervix. The overall five years survival rate is 68 per cent. Lymph node involvement occurred in 15 per cent of cases; non-sterilized cervical stumps represented 24 per cent. Two recurrences and two metastases were observed.

Adenocarcinoma↗