Biomedical subjects
Publications and source records attributed to J Andresen.
Retrospectively the urographic findings, history, clinical signs and surgical/pathologic features of 46 Wilms' tumours were analysed. Imparied or no function of the kidney was associated with a high incidence of defects of the renal pelvis and invasion of the renal vein. A high rate of non-radically operated or inoperable tumours and high mortality was present in these cases.
A case with severe haemoptysis nearly three weeks after a chest trauma is presented. Aortography revealed rupture of the aorta below the origin of the left subclavian artery. The rupture was caused by a fractured rib which also caused a tear in the lower lobe of the left lung. Aortic haemorrhage had dissected into the lung, causing a haematoma and finally resulting in a severe haemoptysis.
Early radiologic signs and the radiologic course were examined retrospectively in 20 renal transplant patients who developed osteonecrosis after transplantation. Osteonecrosis appeared in 25 hips, 8 knees, 9 shoulders and 1 elbow. In most patients who developed osteonecrosis of the hip the early radiologic signs of osteonecrosis, with areas of lucencies and increased densities, were preceded by a thin fracture line in the immediate subchondral bone, parallel to the articular surface, appearing within a mean of 14 months after renal transplantation. This change seems to be a specific and very early finding in patients who subsequently develop osteonecrosis after renal transplantation. The initiation of collapsing phenomena of the articular surface was preceded by architectural changes near the articular surface wtih areas of lucencies and sclerosis. At the time of this investigation 26 per cent of the bones showed signs of regression of the changes with rebuilding of the former shape; 32 per cent showed progression and in 42 per cent the condition was stationary.
Seventy-seven renal transplant (RT) recipients were studied radiologically with regard to bone lesions and metacarpal bone mass, at the time of and after renal transplantation. An increased incidence of rarefaction of the spine, a reduced metacarpal bone mass and an increased frequency of subperiosteal erosions were found at the time of transplantation in RT patients who subsequently developed osteonecrosis or spontaneous fractures as compared with RT patients who did not develop these bone complications. During the years after RT an increase in rarefaction of the spine, in subperiosteal erosions, in soft tissue calcifications and a decrease in metacarpal bone mass were found in all patient groups.
31 renal transplant recipients with post-transplant development of osteonecrosis or spontaneous fractures were evaluated with regard to age, duration of dialysis before transplantation. Determination of metacarpal bone mass at the time of transplantation and registration of bone resorption and soft tissue calcification at the time of transplantation and at the time of onset of osteonecrosis and spontaneous fractures were made. Apart from the increased mean age in patients with spontaneous fractures no difference was seen between the groups. Osteonecrosis and spontaneous fractures occurred in areas of trabecular bone. It seems most likely that after renal transplantation the patients show bone complications of different localization.
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Radiologic bone lesions in 20 long-term hemodialyzed patients with chronic renal failure are described. During chronic dialysis the bone lesions increased. Treatment of 8 patients with 1 alpha-OH-D3 for 6 months prevented progression of the bone lesions or improved them.
Radiologic bone lesions in 92 non-dialysed patients with chronic renal failure are described. The bone disease increased with the severity of renal failure. In a prospective series of 20 patients progression of osteodystrophy and decrease in metacarpal bone mass were demonstrated.
Twenty-eight cases of dissecting aneurysms of the thoracic aorta in patients with hypertension, syphilis, Marfan's syndrome and with unknown aetiology are analyzed with regard to the origins and extent of the dissection angiographically. The most common symptoms and evident radiological findings of the plain radiographs of the chest are stressed. The prognosis depends on the type of dissection.
A retrospective analysis of traumatic ruptures of the aorta is presented. Importance is stressed upon the plain chest film as the primary examination. Angiography revealed false aneurysms with classic localization just distal to the left subclavian artery in 10 cases and a transverse intimal tear in one case. The detection of chronic false aneurysms is equally important as they also require surgical repair.
The effects of d-amphetamine and methylphenidate and their interactions with amine-depleting drugs were examined in rats trained to press a lever to obtain water reinforcement on a schedule that differentially reinforced responding at low rates (DRL). Both methylphenidate (2.5-20.0 mg/kg) and d-amphetamine (0.375-3.0 mg/kg) increased the rate of responding and decreased the frequency of reinforcement on the DRL schedule. Both drugs also shifted the interresponse time (IRT) distributions to the left such that the modal IRT occurred well below the minimum IRT required for reinforcement (d-amphetamine was abut eight times more potent than methylphenidate for each of these effects). The effects of both d-amphetamine and methylphenidate on DRL performance were attenuated by administration of alphamethyltyrosine (AMT) (150 mg/kg) and both drugs attenuated the response rate-suppressing effects of tetrabenazine (TBZ) (4.0 mg/kg). The similarity of the drug interactions between methylphenidate or amphetamine and AMT or TBZ suggest that the doses of methylphenidate and d-amphetamine examined act on similar catecholaminergic pools with the central nervous system to influence DRL performance.
A total of 45 patients have undergone an Inkwell esophagogastrostomy after resection of a benign esophageal stricture. Nineteen patients were available for a long-term follow-up study, showing evidence of gastroesophageal reflux in 16 patients. Due to the high incidence of reflux and subsequent morphologic changes, there was a not negligible late disability. The Inkwell esophagogastrostomy can no longer be recommended in the treatment of an underlying reflux-induced lesion, strictures included.
In diagnosing a Meckel's diverticulum besides the conventional plain films of the abdomen with and without contrast and the angiographic special attention is called to the scanning with technetium. This examination can be very helpful in cases of children with gastrointestinal bleeding episodes in the diagnosis of a Meckel's diverticulum, if it contains ectopic gastric mucosa.
Abdominal masses localized to the region of the kidney in the newborn require different diagnostic procedures. Taking advantage of cystourethrography, retrograde and intravenous pyelography and angiography, it should be possible to make the right diagnosis as in our two cases demonstrating renal vein thrombosis.
Reference is made to two cases of mycotic aneurysm with different peripheral localizations, arising from a bacterial endocarditis. The cause, localizations, complications and histological findings are discussed.
Reference is made to a case of mycotic aneurysm of the superior mesenteric artery caused by bacterial endocarditis with streptococcus feacalis combined with reversible neurologic complications. On account of improvement in the treatment a careful radiological examination is very important with exact account of the size and localisation of the aneurysm. Our patient was successfully treated with aneurysmectomia and reconstruction of the vessel by transplantation of a vein.
The diagnostic value of 100 mm-spotfilm-technique for investigations of the colon has been evaluated and compared to the conventional screen film technique. No difference has been found between the diagnostic value of the two methods, but the total number of exposures in the spotfilm technique has to be increased compared to the conventional method. There is a reduction of the x-ray dose, though not as big as expected.
The omphalocele is very often combined with congenital malformations and is primarely to be looked at as a medical and surgical disease. The radiological examination possibly can help to decrease the rate of mortality by disclosing the malformations. These very often consist of malformations, complicating ileus and Bochdalek's hernia. We present 23 cases with omphalocele with special regard to the congenital malformations, complications postoperatively and the causes of death.