Biomedical subjects
Publications and source records attributed to J Archer.
Samaritan's Purse is widely known for our Operation Christmas Child program. The program has been a phenomenal success, growing from 110,000 donated shoe boxes in 1994 to 2.3 million in 1998--an annual growth rate in excess of 110 percent.
A 33-item measure of homesickness (the Homesickness Questionnaire, HQ) was derived from features of grief modified for the circumstance of separation from home. In three samples of year 1 students (N = 264) during their first year at university, total HQ scores were highly correlated with a single-item measure of homesickness used in previous studies, and 28 items showed significant differences between subgroups divided on the basis of the single-item scores. Previous findings that homesick students show more health and psychological symptoms, and cognitive failures, were supported by further comparisons between the two groups, and a meta-analysis of four studies. Factor analysis of the HQ indicated two factors, disliking the university, and attachment to the home, which are consistent with both the separation and strain models of homesickness. Correlations with other variables, and sex differences in the factor scores, further supported the distinction between these two aspects of homesickness. Women showed higher levels of intrusive thinking about the homesickness, but this was mediated by their higher scores on the attachment factor of the HQ. There was no sex difference in avoidant responses to homesickness.
The heat resistance of Salmonella weltevreden inoculated into flour and heated in hot air was determined for (a) an initial water activity (aw) range of 0.20 to 0.60 prior to heating, (b) a range of storage relative humidities of 6.0 to 35.5% prior to heating, and (c) temperatures of 57 to 77 degrees C. The death curves obtained were biphasic, demonstrating an initial rapid decline in the numbers of survivors (1.0- to 1.5-log reductions) during the first 5 to 10 min of heating for all the temperature-water activity combinations tested. Following this initial rapid decline in the number of cells, a linear survivor curve was obtained where inactivation occurred at a slower rate. The initial decline in survivors coincided with a rapid decrease in the water activity of all the samples tested. Irrespective of the initial water activity level in the samples prior to heating, the aw decreased to < 0.2 during the first 5 to 10 min of heating. The D values obtained for these experimental parameters ranged from a D60-62 of 875 min at an initial aw of 0.4 to a D63-65 of 29 min at an initial aw of 0.5. The results demonstrated that, for any temperature, as the initial water activity of the sample prior to heating decreased, the heat resistance of the cells increased. The z values obtained from these data ranged from 15.2 to 53.9 degrees C. The relative humidity during storage prior to heating did not appear to have a significant effect on the heat resistance of S. weltevreden in flour. These results demonstrate that the amount of available water in foods that are considered to be "dry" (i.e., with a water activity less than 0.60) will significantly influence the effectiveness of the heat processing of foods and, in addition to the temperature, the aw prior to heating is a critical controlling factor during these processes.
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In Study 1, a 40-item questionnaire measuring instrumental and expressive beliefs about aggression, along a five-point scale, was developed. It was based on a 20-item questionnaire (Campbell, Muncer & Coyle, 1992) where the two alternatives were forced choices for each item. In the present study the two sets of beliefs were only moderately correlated (-.35), and their separation into 20-item scales showed a clearer factor structure than combining all 40 items. Men showed higher instrumental scores whereas women showed higher expressive scores: factor analysis revealed one major factor in each case on which items showing the highest sex differences were concentrated. In Study 2 the questionnaire was used on another sample to assess the association between these beliefs and self-reported physical and verbal aggression, and anger. Instrumental beliefs were found to be highly correlated with physical aggression, and to a lesser extent verbal aggression. In this study, sex differences were similar to Study 1, but were complicated by the finding of stronger instrumental beliefs at younger ages for both sexes. In both studies, when filling out the questionnaire, women were equally likely to think of an aggressive episode with a same-sex opponent as with an opposite-sex partner whereas men nearly always thought of an aggressive episode with a same-sex opponent. However, neither instrumental nor expressive scores were affected by whether female respondents were thinking of a partner or same-sex other.
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The competing claims of two explanations of sex differences in social behavior, social role theory, and evolutionary psychology are examined. The origin and scope of research on sex differences in social behavior are outlined, and the application of social role theory is discussed. Research that is based on modern sexual selection theory is described, and whether its findings can be explained by social role theory is considered. Findings associated with social role theory are weighed against evolutionary explanations. It is concluded that evolutionary theory accounts much better for the overall pattern of sex differences and for their origins. A coevolutionary approach is proposed to explain cross-cultural consistency in socialization patterns.
The replacement of biological products in media for the collection, culture and freezing of mammalian embryos was studied. To test the hypothesis that chemically defined surfactants can replace bovine serum albumin (BSA) or serum in embryo media, morula-stage mouse and cattle embryos were collected, cultured, and/or frozen in the surfactant compound, VF5. Collection efficiency of mouse and cattle embryos did not differ whether the medium contained serum or surfactant. In addition, morula-stage mouse and cattle embryos developed and hatched at similar rates in culture media containing either BSA or surfactant. Although the freeze/thaw survival and development in culture of bovine embryos was not significantly different in any of the media, there was a significantly lower hatching rate of mouse embryos frozen with serum or surfactant than with cryoprotectant alone or with cryoprotectant plus albumin-free serum. However, the absence of serum or surfactant in embryo freezing media resulted in embryo loss, presumably due to stickiness. The data suggest that serum can be replaced by a chemically defined surfactant in mouse and cattle embryo transfer systems for the collection, culturing and freezing of embryos. It is likely that the beneficial effects of serum are due to its surfactant properties.
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In this article we report and discuss the pulmonary complications in patients who received a single exposure total body irradiation (TBI) to a total dose of 7.5 Gy at a dose rate of 0.15 Gy/min, a TBI regimen which has the advantage of being given in a single, relatively short exposure, with an active treatment time of less than 1 hour. This forms a part of the bone marrow transplantation programme for the management of certain haematological malignancies at the Leicester Regional Centre. Between July 1986 and October 1990, we treated 31 patients with such a regimen. Full respiratory function tests (RFT) were carried out, prior to TBI, in the majority of patients. After a mean follow-up period of 34 months, 13 patients were alive; full RFT were repeated in all of them. Of the total of 31 patients, only one patient died, from late non-specific pneumonitis; in this case, high dose busulphan was added to conventional cyclophosphamide and TBI. Another patient died as a direct result of cytomegalovirus pneumonia. Comparison of pre- and post-TBI RFT showed no resultant obstructive, restrictive or transfer factor defects. In the three patients who did not have pre-TBI RFT, post-TBI RFT did not reveal any significant change from expected values for age, sex and height. Several major centres have reported their experience using various combinations of different total doses, dose rates and fractionations. Having compared our results with theirs, we conclude that, following this relatively short and convenient single exposure TBI, there is no evidence of increased acute or chronic pulmonary toxicity.
Three dynamic face-processing tasks based on the Bruce & Young (1986) functional model of face processing were presented to 10 schizophrenic and 10 depressed inpatients and to 10 non-patient subjects. Familiar face recognition, facial expression recognition and unfamiliar face matching were examined. Schizophrenic patients' performance was significantly poorer than that of depressed patients and non-patient controls. Significantly lower scores were obtained on the facial expression recognition task than on the familiar face recognition task. There was a differential pattern of group performance on each of the three tasks: schizophrenic and depressed patients were as accurate as non-patient controls on the familiar face recognition task, but significantly less accurate than non-patient controls on the unfamiliar face-matching task. Schizophrenic patients were significantly less accurate than depressed patients and non-patient controls on the facial expression recognition task. The results are contrasted with an analogous static face-processing study.
A 40-item questionnaire based on reactions following human bereavement was used to investigate the occurrence of grief following death of a pet in a sample of 88 people. Items indicating initial numbness or disbelief, preoccupation with the loss, a loss of part of themselves and being drawn towards reminders were endorsed by half to four-fifths of the sample. About a quarter reported the urge to search, avoidance or mitigation strategies, anger, anxiety and depression. The questionnaire showed high internal reliability, and total scores were significantly positively correlated with the degree of affective attachment to the pet, the suddenness of the death and whether the respondent lived alone; but not with the type of pet, the time since it had died, and how long the owner had been with it. Factor analysis of the questionnaire revealed one main factor accounting for about a third of the variance, described as emotional distress associated with the loss; two lesser factors involved items representing personal importance of the loss and a feeling of continued attachment. Overall these findings indicate a parallel reaction to that following a human bereavement, but with a lower frequency of affective distress. Moderator variables were also comparable with those known to be important for grief following a human loss.
This article describes the development of radiation protection standards, including laws covering equipment, personnel and patients, from a historical and evolutionary standpoint. Laws for the safe use of equipment, guidelines for occupational exposure and means of patient protection are developed from reports and recommendations of national and international organizations. In the United States, some of these laws operate at the federal level and others at the state level. This process is not always well-understood due to the number of organizations involved. This article outlines the process for the radiology manager.
This study assessed the applicability of the grief process to job loss. A pilot study of 10 unemployed men was used to establish a structured interview, and its content analysis, based on a description of the grief process derived from studies of bereavement. Other measures assessed the degree of attachment to the former job. The main study involved 60 men who had lost their jobs during the previous eight years. Individual grief items were found in some of these people, varying in frequency from 10 to 80 per cent. Principal components analysis revealed a general grief component, representing most of the specific items. Twenty-seven per cent of the sample fulfilled a criterion for a clear grief-like response. An overall grief score based on the interview answers was significantly correlated with three different measures of job attachment, and also with questionnaire measures of depression and anxiety. These measures were unrelated to the length of time since job loss, apparently providing no support for stage theories or for more general assumptions of adaptation. However, the cross-sectional nature of the sample complicates this conclusion.
Functional models of face processing have indicated that dissociations exist between the various processes involved, e.g. between familiar face recognition and matching of unfamiliar faces, and between familiar face recognition and facial expression analysis. These models have been successfully applied to the understanding of the different types of impairment that can exist in neuropsychological patients. In the present study, aspects of face processing in psychiatric patients were investigated in relation to Bruce & Young's (1986) model. Based on this functional model different predictions can be made. We contrast here the impaired expression analysis hypothesis, which is that psychiatric patients would show a deficit in facial expression recognition, but not in facial identity recognition or unfamiliar face matching, with the generalized deficit hypothesis, that patients would be impaired on all tasks. These hypotheses were examined using three forced-choice tasks (facial recognition, facial expression recognition, and unfamiliar face matching) which were presented to schizophrenic and depressed patients, and to non-patient controls. Results showed that schizophrenic patients performed at a significantly lower level than non-patient controls on all three tasks, supporting the generalized deficit hypothesis.