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Biomedical subjects

J Archer

Publications and source records attributed to J Archer.

At least 73 records · Page 4Linked to original sources
PubMed1978

Hyperpigmentation of pernicious anemia in blacks. Report of three cases.

We investigated three black women who had anemia and skin hyperpigmentation. They were found to have pernicious anemia (PA) and normal adrenal functions. To our knowledge, this is the first report of skin hyperpigmentation of PA in black patients. This report reemphasizes the similarities in clinical features of PA and Addison's disease.

Addison Disease↗
PubMed1977

Testosterone and persistence in mice.

In view of previous studies showing that testosterone increases persistence of food searching in chicks, a single factorially-designed experiment was carried out to investigate whether a similar phenomenon occurs in male mice. Using a runway test, it was found that testosterone, injected into castrated mice, did increase persistence. It was also shown that intact males resembled more the testosterone-injected than control-injected castrates, and that females resembled neither intact males nor either group of castrates. A larger number of training trials was found to affect feeding latencies in a similar way to testosterone. Comparison of two strains differing in emotional reactivity (BALB/c and Porton) showed differences consistent with their reactivity levels.

Animals↗
PubMed1977

Sex differences in the emotional behaviour of laboratory mice.

Three laboratory strains of mice (C57, BALB/c, Porton) were tested in an open field using a number of measures taken during the initial 2 min of testing and after a loud bell had sounded. The mice were tested either in a clean field or in one containing an odour of a same-sex conspecific. Over all three strains, several measures indicated that females showed high leveles of 'emotional' or 'fear' responses than did males. This sex difference was found in C57 and BALB/c strains but not in the Portons; it could not be attributed to activity or response-specific sex differences. Conspecific odours did not influence the direction of the main findings.

Animals↗
PubMed1975

Open-field behaviour of oestrous and dioestrous rats: evidence against an 'emotionality' interpretation.

Oestrous and dioestrous rats were observed during the initial 2 min of open-field exposure, and after a loud bell had sounded. Although defecation and ambulation showed characteristic difference between the two phases (less defecation and more ambulation at oestrus), other measures associated with emotional behaviour (latency to move from the wall, flight, and freezing to the bell) showed no differences. These findings supported Drewett's suggestion that open-field defecation and ambulation change with oestrous phase because of general metabolic changes and not as a result of 'emotionality' changes.

Animals↗
PubMed1975

The effect of high and low doses of cycloheximide on nucleolar ribonucleic acid synthesis.

In resting rat liver a dose of cycloheximide (1 mg. per kg.) inhibits leucine incorporation by 80 per cent whereas doses above 15 mg. per kg. inhibit it more than 90 per cent, when tested at 90 minutes following intraperitoneal injection. Initial stimulation of incorporation of orotate into total cellular, nuclear, and nucleolar fractions was seen at all doses tested. After 3 hours, however, marked suppression of incorporation particularly into nucleolar RNA was seen at 5 mg. per kg. and above while 1 mg. per kg. continued to stimulate. At 5 hours there was continued marked inhibition of RNA synthesis by 30 mg. per kg. and slight depression of RNA synthesis even by 1 mg. per kg. Preliminary ultrastructural studies failed to show objective nucleolar alterations even after 5 hours of cycloheximide treatment at a dose of 30 mg. per kg. No direct effect of several concentrations of cycloheximide on RNA synthesis was seen in an in vitro nucleolar system.

Animals↗