[Transplantation of hepatocytes: myth of reality].
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Biomedical subjects
Publications and source records attributed to J Arias Díaz.
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A study was made of 44 patients who underwent liver transplant, distributed into three groups: Group A: patients who had ample liver dissection before entering bypass. Group B: patients who entered bypass after dissection of the hepatic hilum and prior to any other dissection; bypass time was prolonged for meticulous hemostasia. Group C: patients with perfectly defined hemodynamic problems, not secondary to bleeding, during the anhepatic phase. Preoperatively the three groups were homogeneous as regards clinical situation. During the operation a significantly larger transfusion volume (p less than 0.01) was administered in group C during phase II (70.1 +/- 27.2 ml/kg/h), phase III (32.6 +/- 9.6 ml/kg/h) and throughout surgery (32.7 +/- 10.3 ml/kg/h) than in the other two groups. Group B received a smaller transfusion volume during phase II (14.6 +/- 8.1 ml/kg/h), phase III (12.7 +/- 5.5 ml/kg/h) and throughout surgery (11.6 +/- 4.9 ml/kg/h) than the other two groups (p less than 0.01). The transfusion needs of group A were 28.4 +/- 15.6 ml/kg/h in phase II, 26.8 +/- 17.1 ml/kg/h in phase III and 21.2 +/- 11.2 ml/kg/h throughout surgery. The duration of the anhepatic phase was significantly shorter (p less than 0.01) in group A (1 h 10' +/- 10) than in (1 h 50' +/- 10) and C (1 h 40' +/- 45'). In the postoperative period a higher mortality was associated with group C (37.5%) and a lower mortality with group B (3.33%), the mortality of group A being 16.6%. The differences were statistically significant with p less than 0.01.
The initial results of biliary reconstruction in 72 liver transplants realized in 62 patients, 50 adults and 12 children, are presented. Three reconstruction techniques were used: end-to-end choledocho-choledochostomy on a Kehr tube in 44 transplants (61.1%); choledocho-jejunostomy on a Roux-en-Y loop in 24 transplants (33.3%); double derivation cholecysto-choledocho-jejunostomy in 2 transplants (2.7%). The number of early complications related to biliary reconstruction was 5 (7.14%): 3 fistulas in the choledocho-choledochostomy series (6.8%) and 2 fistulas among the choledocho-jejunostomies (8.3%). All complications required reoperation and mortality was nil. Thirty-two months after the onset of the program, no late complications of the biliary anastomosis have been registered.
The quality of the socio-affective adaptation of liver transplant patients is a fundamental assessment parameter in the context of postoperative recuperation. The patient's reinsertion into the socio-occupational environment, gradual recuperation of professional and recreational habits and psycho-affective reorganization represent, in our opinion, the most significant criteria for evaluation of the "modus vivendi" of the transplant patient. A total of 21 patients between 21 and 62 years were evaluated. They were divided into three groups for study and analysis. The remission of symptoms and normalization of organic activities, in addition to achievement of an adequate quality of life, constitute the basic rationale for any surgical intervention.
Two cases are presented of liver transplantation in adult patients with fulminant liver failure using grafts from incompatible blood group donors due to the urgency of the situation. The patients evolved well as first but later both developed ischemia and necrosis of the bile tract secondary to severe rejection. It is concluded that the use of incompatible grafts can save the patient's life in acute irreversible liver failure, but in most cases retransplantation may be necessary as the definitive treatment of postoperative complications.
Three patients are reported who had liver hydatidosis that was not resolved by conventional surgery and who eventually underwent liver transplantation. In view of the satisfactory results obtained, with 100% postoperative survival, possible indications for liver transplant in this type of patients are discussed, fundamentally for secondary sclerosing cholangitis, secondary biliary cirrhosis and acute Budd-Chiari syndrome.
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A series of 269 patients with 371 surgically treated hydatid cysts of the liver is reported. Cystopericystectomy was performed in 45.2% of cases, liver resection in 7%, subtotal cystectomy in 26.9%, cystojejunostomy in 1.8% and drainage in 9.7%. Overall mortality and morbility were 2.9% and 31% respectively, with a mean hospital stay of 29 days. The highest mortality (6%) and morbility (45%) were observed in patients undergoing subtotal cystectomy. In the group of patients treated by conservative surgery the overall mortality was 32.5%, while in the group treated by radical surgery it was 27% (p less than 0.05). These data suggest that in the treatment of hydatid disease radical resection is followed by the lowest complication and mortality rates.