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Biomedical subjects

J Arias Irigoyen

Publications and source records attributed to J Arias Irigoyen.

8 recordsLinked to original sources
PubMed2003

Occupational rhinoconjunctivitis from white pepper.

A 44-year-old subject developed rhinoconjunctivitis symptoms when she was exposed to white pepper while working in the food industry. A positive skin prick test for white and black pepper extracts (1:10 w/v) were obtained. Specific IgE antibodies to white and black pepper were demonstrated by ELISA. The immunoblot analysis showed two IgE-reactive protein bands able to bind to IgE from white pepper extract of 11.8 kDa and 13.6 kDa and one band from black pepper extract of 11.8 kDa. IgE binding to blotted white and black pepper extract were inhibited by preincubation of patient serum with black pepper extract. A conjunctival provocation test was positive with a white pepper extract dilution of 1:100 w/v. We describe a patient with occupational rhinoconjunctivitis caused by hypersensitivity to white pepper.

Adult↗
PubMed1997

[An analysis of the treadmill exercise test in a population of mild and moderate extrinsic asthmatics].

The bronchial response to physical exercise on a treadmill was analyzed in 48 patients with mild to moderate extrinsic asthma diagnosed by clinical criteria and a positive methacholine test, and in 36 non-asthmatic subjects. Bronchoconstriction secondary to physical exercise was documented by measuring the percent fall in PEF in different post-exercise control times. Significant differences (p < 0.00001) were observed between bronchial response in asthmatic and non-asthmatic patients. By using ROC curves an optimal cut-off was obtained in a fall equal to or greater than 6% 10 minutes post-exercise, with a sensitivity of 0.75 and an specificity of 0.923. The bronchial challenge test with physical exercise on a treadmill, within the limits of the studied sample, can be used as a method for detecting BHR in asthmatic patients.

Adolescent↗
PubMedDate not supplied

Mild to moderate asthmatics and free running.

We analyzed the bronchial response to free running in 48 mild to moderate extrinsic asthmatics and 36 nonasthmatics and also studied the relation between the methacholine hyperresponsiveness (expressed as PC20) and the changes in peak flow (PEF) post-exercise in an asthmatic group. The highest bronchial response to exercise was observed in asthmatic patients 10 min after free running (17.93 +/- 13.37%) and was significantly different from the nonasthmatics (U = 156; p > 0.00001). The correlation study disclosed a high correlation (r > or = 0.6) between the PC20 values (expressed as logarithmic transformation) and the exercise response (percent drop in the PEF measured 10 and 15 min post-exercise) in asthmatic subjects. With receiver operator characteristic (ROC) curves we obtained, as an ideal point, a percentage change in PEF (PEFR) of 8% or more measured 10 min post-exercise which reached 79.1% sensitivity and 89.7% specificity. We think that this exercise challenge can be used for detection of airway hyperresponsiveness in mild to moderate asthmatics.

Adolescent↗
PubMedDate not supplied

Toxocariasis: a cause of hyper IgE and eosinophilia.

We present a patient with elevation of total serum IgE, eosinophilia and Toxocara exoantigen specific IgG and IgE antibodies (detected by ELISA and RAST, respectively). We ruled out atopy and other parasitic diseases common in our habitat (e.g., Echinococcus granulosus, Ascaris lumbricoides, Schistosoma mansoni). The patient was asymptomatic over the four years of the study, and the levels of total serum IgE, eosinophils and Toxocara exoantigen specific IgG and IgE remained high. Although at present, immunodiagnostic tests have a high sensitivity and specificity for toxocariasis, their value is limited. This is illustrated by the fact that in our patient these techniques could not distinguish between past and present infection.

Adult↗
PubMedDate not supplied

Absence of late responses after exercise challenges in patients with mild and moderate extrinsic asthma.

We assessed the occurrence of early bronchial response and late bronchial response after the tread mill and free running exercise tests in 46 mild and moderate extrinsic asthmatics. On the treadmill 24 asthmatic subjects (52.1%) had an early post-exercise fall in PEF greater than ten percent and they were considered to have exercise induced asthma. In the free running 30 asthmatic patients (65.2%) had exercise induced asthma no asthmatic subjects showed a fall in PEF equal to or more than 20 percent during late response period. On control day PEF levels during this time were similar 4 to 13 hours post-exercise PEF values. We reported no significant correlation between early post-exercise PEF values and PEF levels during late response period after the treadmill and free running exercise tests. This study demonstrates the absence of a late response in EIA after the treadmill and free running exercise tests, at least in young people with mild or moderate extrinsic asthma.

Adolescent↗