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Biomedical subjects

J Asconapé

Publications and source records attributed to J Asconapé.

10 recordsLinked to original sources
PubMed2000

Myoclonus associated with the use of gabapentin.

PURPOSE: To report on the occurrence of myoclonus in patients receiving gabapentin (GBP) for the treatment of epilepsy. METHODS: Clinic charts of 104 consecutive patients started on GBP were reviewed. All patients were treated by the same physician, and most were specifically asked about the presence of myoclonus. RESULTS: We found 13 cases of myoclonus. All patients had refractory epilepsy and were taking other antiepileptic drugs (AEDs). Six patients had a severe chronic static encephalopathy; five patients had no medical diagnosis other than seizures. Ten patients developed multifocal myoclonus. Three patients developed focal myoclonus, contralateral to their epileptic focus. Two patients had an exacerbation of preexistent myoclonus. An EEG performed during myoclonus on three patients showed no correlate. The myoclonus tended to persist as long as GBP was maintained, whereas discontinuance of GBP resulted in rapid cessation of the myoclonus. In all cases the myoclonus was subtle and did not significantly interfere with daily activities. CONCLUSIONS: GBP-associated myoclonus appears to be relatively frequent. It is usually mild and can easily be overlooked. Discontinuation of therapy is not necessary in most cases.

Acetates↗
PubMed1995

Embolic pontine infarction in a nonhypertensive patient following coronary angioplasty.

A 63-year-old woman was found to have decreased vibration, light touch, and proprioception sensations in the right hemi-body, following cardiac angioplasty. The patient was not hypertensive although she had a history of hypercholesterolemia and was a smoker. Magnetic resonance images of the brain demonstrated abnormal signal intensity in the left paramedian basis pons anterior to the fourth ventricle. The lesion was believed to be consistent with a lacunar infarction. Unlike this woman, the majority of patients who have a small-vessel stroke are usually diabetic or hypertensive. The interesting features here were that the stroke was a complication of coronary angioplasty, was cardioembolic to the pons, and was falsely localized to the thalamus. In addition, rarely does an embolic stroke involve a single brainstem tract.

Angioplasty, Balloon, Coronary↗
PubMed1993

Bruxism secondary to chronic antidopaminergic drug exposure.

Eight cases of diurnal bruxism (DB) secondary to long-term antidopaminergic drug exposure are reported. Five exhibited a grinding pattern, one a clenching form, and two a mixed type. An odontological etiology was absent throughout. EMG recordings disclosed two distinct patterns of muscle activity, one with brief rhythmic, forceful contractions and the other featuring sustained prolonged contractions. Surface EMG and EEG monitoring during a 24-h period confirmed the absence of bruxism during sleep. Several drug trials failed to provide relief. Our findings support DB as a focal tardive dystonia syndrome.

Aged↗
PubMed1984

Some clinical and EEG aspects of benign juvenile myoclonic epilepsy.

Twelve patients with benign juvenile myoclonic epilepsy (BJME) representing 4% of our population of epileptics (n = 275) are presented. Only two patients (17%) had myoclonic jerks as the only seizure type. Seven (58%) had generalized tonic-clonic seizures (GTCS) and myoclonus. Three patients (25%) had absence seizures (AS), GTCS, and myoclonic jerks. Electroencephalographic evidence of photosensitivity was found in four (33%). Auditory precipitation of seizures was found in one patient. As is the case with other primary generalized epilepsies, the onset of BJME seems to be age specific. In our series the mean age of onset in years was 4.3 for AS, 14.75 for myoclonic jerks, and 16.4 for GTCS. It took an average of 8.5 years from the onset of BJME (range, 2-20 years) and 6.5 years from the onset of GTCS (range, 2 months-6 years) until the condition was properly recognized. Five patients experienced at least one episode of myoclonic status epilepticus. Generalized, paroxysmal, symmetric polyspike and slow wave discharges are the typical EEG finding. These complexes, however, showed considerable interpatient variability. Sleep deprivation proved to be the most valuable activating procedure. Valproic acid monotherapy effectively controlled myoclonic jerks as well as associated GTCS in most patients.

Adolescent↗
PubMed1983

Intracranial metastases from carcinoma of the cervix.

Intracranial metastases in patients with carcinoma of the cervix are rarely reported. We present three such patients, two of whom had intraparenchymal metastases and a third with involvement of bone and dura.

Adenocarcinoma↗
PubMed1981

Spongy degeneration of the nervous system associated with propionic acidemia.

The pathologic changes in the brain of a five and a half month old male child who died of propionic acidemia are presented. Although previous pathologic reports of this disorder describe either no involvement of the central nervous system or focal myelin sheath vacuolization, the present case exhibited different pathology, namely, spongy degeneration of the white matter of Van Bogaert and Bertrand's type. Thus this case illustrates that the pathologic changes in the brain in propionic acidemia are variable. In addition, the cerebellum in this patient showed marked diffuse atrophy and early loss of the external granular layer, two changes that have not been emphasized by previous authors.

Amino Acid Metabolism, Inborn Errors↗
PubMedDate not supplied

A case for cerebral thromboangiitis obliterans.

The existence of cerebral thromboangiitis obliterans (CTAO) has been controversial. The clinical, laboratory and angiographic features of a young woman with recurrent thrombophlebitis, digital gangrene and a bilateral anterior opercular syndrome (Foix-Chavany-Marie) are reported. The cerebral angiogram demonstrated significant narrowing of fronto-opercular branches of both middle cerebral arteries. Histology of small digital muscular arteries revealed segmental adventitial fibrosis, narrowing or occlusion of lumen and mild lymphocitic infiltrates; occasional veins showed phlebitis. An etiologic relationship between cerebral occlusive disease and peripheral thromboangitis obliterans (TAO) is suggested.

Adult↗