Methicillin-resistant Staphylococcus aureus in Bangladesh--a multicentre study.
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Biomedical subjects
Publications and source records attributed to J Ashraful Haq.
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The prevalence of extended-spectrum beta-lactamases (ESBL)-producing organisms in an urban hospital in Dhaka City was assessed over a 10-month period. A double disk test was performed to detect ESBL-producing Escherichia coli and Klebsiella pneumoniae. 43.2% and 39.5% of E. coli and K. pneumoniae had ESBL phenotypes, respectively. The combination of augmentin with ceftazidime detected the most ESBL-producing E. coli (39.5%) while augmentin with ceftriaxone was the best combination for the detection of ESBL (31.6%) in K. pneumoniae.
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Salmonella typhi is an important cause of enteric fever in Bangladesh. Resistance to commonly used antibiotics like cotrimoxazole and ampicillin has led to the introduction of third generation cephalosporins and fluoroquinolones for the treatment of enteric fever. Prescription patterns for enteric fevers and for other infections have been changing and so we looked at the antibiotic resistance of S. typhi isolated from patients in and around Dhaka City from 1996-1998. The study showed a gradual change in resistance to ampicillin and cotrimoxazole among S. typhi in our area. The rate of resistance to cotrimoxazole, ampicillin and chloramphenicol decreased from 59.6 to 5.6% in S. typhi over a 3 year period. The extensive use of third generation cephalosporins and fluoroquinolones, in place of conventional antibiotics, has probably influenced the change in resistance pattern in S. typhi.