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Biomedical subjects

J Aström

Publications and source records attributed to J Aström.

27 records · Page 2Linked to original sources
PubMed1983

Intellectual ability of adults after lifelong intestinal malabsorption due to coeliac disease.

The intellectual impact of lifelong intestinal malabsorption was examined in a consecutive series of 19 adults (mean age, 48 ± 11 years) with untreated coeliac disease. Using a comprehensive test battery no consistent signs of cognitive impairment were found and in the light of recent observations on coeliacs, aspects of nutritional deficiency may prove more pertinent to other forms of cerebral dysfunction.

Adult↗
PubMed1983

Reversal of psychopathology in adult coeliac disease with the aid of pyridoxine (vitamin B6).

Signs of mental depression are typical in adults presenting with coeliac disease. The response to treatment was evaluated in 12 consecutive patients by means of the Minnesota Multiphasic Personality Inventory (MMPI), with surgical patients serving as controls. The coeliacs reported no change in depressive symptoms after 1 year's gluten withdrawal despite evidence of improvement in the small intestine. When retested after 3 years, however, after 6 months of 80 mg/day of oral pyridoxine (vitamin B6) therapy, they showed a fall in the score of scale 2 ('depression') from 70 to 56 (p less than 0.01), which became normalized like other pretreatment abnormalities in the MMPI. Cholecystectomy in the control subjects produced no alterations in the MMPI profile. The results indicate a causal relationship between adult coeliac disease and concomitant depressive symptoms which seems to implicate metabolic effects from pyridoxine deficiency influencing central mechanisms regulating mood.

Adult↗
PubMed1982

Psychic disturbances in adult coeliac disease. II. Psychological findings.

Psychiatric illness has been observed to be a main cause of disability in undiagnosed adult coeliac disease. A consecutive series of 16 patients with newly detected adult coeliac disease underwent assessment of personality by means of the MMPI. The coeliacs scored high, 70.3 +/- 12.5, only on MMPI scale 2 ('depression'), which was the only significant difference from matched surgical controls. The score correlated 0.66 with daily fat excretion (p less than 0.05) but was unrelated to abdominal complaints. The general intellectual level, assessed by the SRB test, was similar in coeliacs and controls. Our results suggest that depressive psychopathology is a feature of adult coeliac disease and may be a consequence of malabsorption.

Adult↗
PubMed1982

Psychic disturbances in adult coeliac disease. III. Reduced central monoamine metabolism and signs of depression.

Untreated adult coeliac patients have previously been shown to have a high frequency of depressive symptoms as reported in a personality inventory (the MMPI). In the present study we determined the concentrations of three major monoamine metabolites in samples of lumbar cerebrospinal fluid of ten consecutive adults with newly detected coeliac disease. They showed significant reduction in levels of 5-HIAA (70.3 +/- 25.4 pmol/ml). HVA (128.2 +/- 58.3 pmol/ml), and MOPEG (27.7 +/- 7.4 pmol/ml), indicating reduced central metabolism in all three monoamine pathways. The concentrations, in particular that of MOPEG, were inversely correlated with depressive symptoms reported on the MMPI scale 2 ('depression'), which conforms with current concepts on the pathogenesis of depression.

Adult↗
PubMed1977

The effect of fenestration on intraosseous drainage in osteoarthritis of the hip.

Eight patients with osteoarthritis of the hip, rest pain and intraosseous hypertension of the proximal femur obtained ameliorated rest pain and reduced intraosseous hypertension 3 months after a fenestration operation in the region of the greater trochanter. They were investigated with intraosseous phlebography of the proximal femur. Six patients showed delayed intraosseous drainage and 7 had altered patterns of drainage before the operation. Three months after the operation the phlebograms showed an even more prolonged drainage time. However, this difference was not of a statistically significant magnitude. Drainage patterns remained mainly unchanged.

Adult↗
PubMed1975

Peroperative effect of fenestration upon intraosseous pressure in patients with osteoarthritis of the hip.

In nine patients with osteoarthritis of the hip who suffered from pain at rest, intraosseous pressure was measured in both the femoral head and neck before and immediately after fenestration in the lateral aspect of the greater trochanter. A small but significant drop in intraosseous pressure in both the femoral neck and head was registered as a result of the fenestration procedure.

Adult↗