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J B Cabello

Publications and source records attributed to J B Cabello.

7 recordsLinked to original sources

[Investigation methods in clinical cardiology. IV. Clinical measurements in cardiology: validity and errors of measurements].

Measurements represent an essential part of clinical activity. Very often, however, relevant disagreement in clinical measurements becomes apparent. The sources of this variability are the subjects (patients) that are measured, the measurement instrument itself, and the observer. The assessment of the quality of measurement usually relies on the evaluation of its reproducibility and its validity. The reproducibility is basically measured as the inter-observer concordance, the intra-observer concordance, and the test-retest concordance. The specific parameter used to its quantification (intra-class correlation coefficient, kappa index, graphic methods, etc.) depend on the kind of variable to be measured. The validity of the measurement is the degree to which the measurement is really measuring what we think it should. If an acceptable standard is available, then so called criterion validity is usually assessed. Otherwise the validity should be assessed by other ways that use subjective criteria (content validity and face validity) or empirical criteria (construct validity).

Cardiology↗

Acute and chronic changes in atrial natriuretic factor induced by ventricular pacing: a self controlled clinical trial.

A self controlled clinical trial was carried out to study the acute and chronic effects of ventricular pacing (VVI) on the atrial natriuretic factor (ANF). Eleven people were selected from a pool of 20 DDD paced patients. Pacemakers were programmed to the VVI mode for 1 month and their effectiveness tested by ECG at rest and after an effort test. AnF was measured by radioimmunoassay at baseline, after 15 minutes, and again 1 month after programming. The reliability of the radioimmunoassay was confirmed using the coefficients of variation between (12.5%) and within assay (9.7%). Data analysis was done using Wilcoxon's test. Our results showed that the onset of VVI pacing led to a sudden sharp rise in ANF in all patients (P < 0.0001). During VVI pacing, three patients were dropped from the study (2 were withdrawn because of symptoms and 1 voluntarily withdrew). After 1 month of VVI pacing, a significant increase of ANF above the baseline was observed (P < 0.05). The results showed that ventricular pacing led to an immediate rise in ANF and, that with long-term VVI pacing, there was an increase in ANF levels as well. The role of these findings in the pathophysiology of the pacemaker syndrome calls for further research.

Adult↗

[Long-term effects of cardiac pacing on natriuretic atrial peptide levels in patients with AV block].

In this work we intend to analyze the long term effects of the classic modes of definitive cardiac pacing (VVI and DDD) on the atrial natriuretic peptide levels. A priori hypothesis is: the AV asynchrony raises the hormonal level. The design is a cross-sectional study, and the setting is the pacemaker doctor's room of a tertiary hospital. In 24 patients (17 VVI and 7 DDD) the atrial natriuretic peptide was determined by RIA. A multiple regression model was fitted to analysis. The basic result is: when several factors were controlled (age, sex, hypertension, and cardiac failure story), the atrial natriuretic peptide levels are increased in the VVI group. In conclusion, the lack of AV synchrony induced the increase of atrial natriuretic levels. For an endocrine viewpoint the DDD is more physiological pacing as well.

Aged↗