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Biomedical subjects

J B Chassan

Publications and source records attributed to J B Chassan.

12 recordsLinked to original sources

Some notes on the foundations and scope of intensive design.

IN THE application of single-case and intensive design to the study of psychopathology and interpersonal processes the primary focus is upon the data of the individual subject as distinct from that of a sample of subjects. Such models begin with the notion that personality processes are stochastic processes. That is, one's moods, affects, signs and symptoms, and interactions with others out of the past or from the present fluctuate over time and with respect to various contingencies in a probability space of a very high order of dimensionality. In practice--that is, in relation to application to a given study or set of studies--we are of course constrained to consider just a very small subspace of this huge hyperspace.

Ethics, Professional↗

Levodopa in Parkinson disease: a long-term appraisal of mortality.

Mortality rates for a group of patients in a collaborative multicenter study of levodopa (Larodopa) in the treatment of parkinsonism were compared with corresponding mortality rates in the general population adjusted for age and sex distribution in accordance with that of the parkinsonian patients under study. The death rate, conservatively adjusted for dropouts among parkinsonian patients, is estimated to be approximately 33% greater than that for the general population. This is in contrast to an earlier study of Hoehn and Yahr, prior to the advent of levodopa treatment, wherein the mortality rate for parkinsonian patients was shown to be in excess of that in the general population by a factor of 2.9, or nearly 200%.

Clinical Trials as Topic↗