Benign prostatic hyperplasia in the nonhuman primate Leontopithecus.
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Acute Disease↗
Biomedical subjects
J B Cruz
Publications and source records attributed to J B Cruz.
Efficacy of abamectin injection against Dermatobia hominis in cattle.
The efficacy of abamectin 1%, when injected subcutaneously in cattle at a dose of 200 micrograms/kg body weight, against the larval stages (grubs) of the fly Dermatobia hominis was evaluated in two trials in endemic areas of Brazil and Argentina. Eighteen Holstein x Brahman castrated males and 16 Brahman-cross with natural infestations were used. Larvae were counted by instar in situ on both sides of each animal before treatment, and were expressed, identified as to stage and classified as live or dead 10 days after treatment. Further larval counts were made periodically until day 79 to evaluate the degree of reinfestation and the stage of larval development. Reinfestation was first detected in the abamectin-treated cattle on day 44. Live larvae were found on 6-8 (Argentina) and on all (Brazil) controls at each post-treatment examination. The difference in numbers of live larvae between treatment groups was statistically significant (P < 0.05) at all post-treatment examinations. These data show that abamectin at a dose of 200 micrograms/kg body weight is highly effective in the treatment and control of established parasitic stages of D. hominis in cattle. No adverse reactions were observed in any of the treated animals.
Animals↗
Osteonectin, bone proteoglycan, and phosphophoryn defects in a form of bovine osteogenesis imperfecta.
Bovine osteogenesis imperfecta is a congenital disease in Holstein cattle having several characteristics in common with human osteogenesis imperfecta syndromes. In particular, affected calves have multiple bone fractures and friable teeth. Bone collagen isolated from the affected animals (Texas variant) showed slightly decreased alpha 1(I) and alpha 2(I) chain electrophoretic mobility and increased hydroxylysine content. Overall collagen was present in the affected bones at 80-90% of normal values. However, osteonectin, a 32,000 Mr bone-specific protein found previously to promote collagen mineralization in vitro and present in abundance (approximately equal to 3% of total protein) in normal calf bone, was severely depleted (less than 2% of normal levels) in the osteogenesis imperfecta bone and dentin. The bone proteoglycan was similarly depleted. In contrast, the bone sialoprotein was not as severely affected. Further, the diseased teeth lacked (less than 10% of normal values) phosphophoryn, a dentin-specific protein normally present as 4-5% of the total calf dentin matrix. The data suggest multiple hard tissue matrix protein deletions, perhaps due to impaired cell development.
Amino Acids↗
A midsystolic ejection click.
A patient of faintly marfanoid habitus with left venticular failure, aortic regurgitation, and rate-related left bundle-branch block was found to have a midsystolic click and echocardiographic findings suggestive of mitral valve prolapse; however, the click did not move earlier in systole in response to head-up tilt or atrial pacing. Cardiac catheterization and angiocardiographic studies revealed severe left ventricular dysfunction out of proportion to the moderate amount of aortic regurgitation observed on aortographic study. Mitral valve prolapse was not confirmed by left ventriculographic study. Intracardiac phonocardiographic and catheter-tip manometric studies identified the click as being aortic in origin, ejection in timing, and midsystolic, rather than early systolic, because of delayed aortic valve opening related to left ventricular dysfunction and delay in conduction.
Adult↗
The HLA antigens and ABO blood groups in an American Black population with mitral valve prolapse.
A total of 42 American Black patients with mitral valve prolapse and 194 healthy individuals of similar ethnic background were tested for the distribution of various HLA antigens and ABO blood groups. The most significant result was an increased frequency of Bw35 in patients (74%) as compared with controls (39%), with a P value of less than 0.0001; the relative risk was 4.45.
ABO Blood-Group System↗
HLA and ABO blood groups in blacks with mitral-valve prolapse.
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ABO Blood-Group System↗
Proof by catheterization of mitral valvular origin of a systolic click.
A patient with a loud intermittent midsystolic click presented a problem in differential diagnosis between mitral valve prolapse (intracardiac origin of the click) and left pneumothorax (extracardiac origin). External phonocardiography performed at the time of cardiac catheterization revealed that this loud midsystolic click disappeared whenever a catheter was positioned across the mitral valve. It reappeared whenever the catheter was removed from the transmitral position. Selective left ventriculography confirmed the diagnosis of mitral valve prolapse.
Cardiac Catheterization↗
Infective aneurysm of the left ventricle: angiographic and echocardiographic features.
A 17-year-old man with staphylococcal endocarditis of the mitral valve developed an infective aneurysm of the posterior left ventricular wall. Echocardiography revealed an echo-free space posterior to the posterior left ventricular wall. This echo-free space undoubtedly represented the aneurysmal sac, because it could be temporarily obliterated by injecting saline into it and was no longer detectable following surgical closure of the sac. Thus echocardiography may be helpful in the detection of an infective aneurysm of the left ventricle.
Adolescent↗