PubMed Health⌕ Search

Biomedical subjects

J B DANIELS

Publications and source records attributed to J B DANIELS.

12 recordsLinked to original sources
PubMed1961

Plaque reduction, a sensitive test for eastern encephalitis antibody.

Serologic surveys of vertebrates to determine rates of eastern encephalitis infection were made to discover the most likely disseminators of virus in nature. Of the techniques available, neutralization is the most specific, and antibody is known to persist for many years. This communication reports a fivefold increase in sensitivity of neutralizing-antibody detection by the application of a plaquereducing technique.

Animals↗
PubMed1953

Myocarditis and pulmonary arteritis in mice associated with the presence of rickettsia-like bodies in polymorphonuclear leucocytes.

A previously undescribed disease of mice, characterized by acute interstitial myocarditis, and by periarterial pulmonary lesions, is reported. The transmissibility of this disease has been shown, but a large proportion of inoculated mice appears to be resistant. Microorganisms, rickettsial in form but not positively identified as such, are consistently present in the lesions. They are found predominantly in the cytoplasm of polymorphonuclear leucocytes. Filtrates of fecal material from normal mice of the Harvard breeding stock may produce lesions in myocardium and pulmonary arteries indistinguishable from those occurring in this disease. Rickettsia-like bodies are also found in these lesions.

Animals↗
PubMed1952

Observations on encephalomyelitis of mice (DA strain).

A new agent, DA, has been isolated from a spontaneously paralyzed mouse. Its biological properties and the pathology of lesions in experimental infection indicate close relationship with the Theiler group of encephalomyelitis viruses. Serological studies were inconclusive. The intracerebral neutralization test failed to reveal measurable antibody and other routes of inoculation were unsuitable because of low invasiveness of the agent. Repeated vaccination of females did not render their offspring resistant to homologous intracerebral challenge. The occurrence of early viremia is reported following intracerebral inoculation of the DA strain and also the known Theiler strains, 4727, FA, and GD-VII. The pathology of mice experimentally infected with DA and with known members of the Theiler group is described. Attention is called to the demyelinating lesion of the cord in mice surviving for several months and to the persistence of virus in the CNS of such animals. Another characteristic feature of the pathology was the degeneration of ventral nerve roots and in some mice of the peripheral nerves. Similar changes were not seen with strains of Theiler virus other than DA. Spheroidal bodies of undetermined significance were found in the lesions. Finally the occurrence of myositis after intracerebral inoculation, not only mice infected with the DA virus, but also with the 4727 and FA strains, is described and discussed.

Animals↗
PubMed1950

A viral agent isolated from a case of "non-paralytic poliomyelitis" and pathogenic for suckling mice: its possible relation to the coxsackie group of viruses.

1. A viral agent, Powers, causing myocarditis, adipositis, pancreatitis, hepatitis, and encephalomyelitis but not myositis in suckling mice 1 to 2 days old has been isolated from the stool of a patient in whom the clinical diagnosis was "non-paralytic poliomyelitis." 2. Serological evidence linking the virus to the clinical disease observed was clear only in the case of "non-paralytic poliomyelitis" from which it was isolated. 3. The possible relation of this agent to the Coxsackie group of viruses is discussed. No serological relationship with the Connecticut 5, Ohio R, and High Point strains was demonstrated. 4. A second virus, Matulaitis, has been isolated from a concurrent case of "non-paralytic poliomyelitis" in the same area. Lesions produced in infant mice by the two agents show certain differences.

Animals↗
PubMed1950

Lesions caused in suckling mice by certain viruses isolated from cases of so called non-paralytic poliomyelitis and of pleurodynia.

A STUDY HAS BEEN MADE OF THE LESIONS PRODUCED IN SUCKLING MICE BY THE FOLLOWING VIRUSES: Powers, Matulaitis, DeMole, Kine, McCarthy, Conn. 5, Ohio R, High Point, WS No. 4, EMC, and Col. SK. Pathologic alterations have been found in myocardium, lungs, liver, pancreas, thymus, brain and spinal cord, adipose tissue, and skeletal muscles. A comparison of the lesions produced by the individual strains has disclosed certain differential features which are discussed in detail. Within the group of so called Coxsackie viruses, myositis has not proved to be a constant finding, and it may occur in suckling mice infected with other types of virus.

Animals↗