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Biomedical subjects

J B DOSSETOR

Publications and source records attributed to J B DOSSETOR.

14 recordsLinked to original sources
PubMed1964

CADAVER RENAL HOMOTRANSPLANTS: INITIAL EXPERIENCES.

Four renal homotransplants were carried out between cadaver donors and four recipients, all of whom were in terminal chronic renal failure. Immune suppression was attempted with azathioprine (Imuran), actinomycin C and prednisone; no radiation was used, nor were the recipient's kidneys, spleen or thymus removed. One patient died with disseminated histoplasmosis at two weeks; another with irreversible homograft rejection at 30 days; a third patient died of septicemia after 9(1/2) weeks with stable renal function. The fourth patient, whose transplant had been ischemic for 190 minutes and had not functioned for 2(1/2) weeks thereafter, eventually achieved good function which remained unchanged to 7(1/2) months. Changes in urinary enzyme excretion and in the I(131) renogram and meralluride scan were of value in assessing homograft rejection.

Azathioprine↗
PubMed1964

LACTICACIDOSIS: A CLINICALLY SIGNIFICANT ASPECT OF SHOCK.

A study was made of the metabolic acidosis of hypotensive shock in 25 patients in an attempt to elucidate its etiology and to determine if the degree of acidosis might be a good parameter for the evaluation of treatment and prognosis.Blood lactate was elevated (> 1.3 mEq./l.) in 24 of 25 patients in hypotensive shock. There was a good correlation (r= 0.83, p < 0.01) between rising blood lactate and decrease in serum bicarbonate and arterial pH, early in shock. These data indicate that the metabolic acidosis of early shock is largely due to lactate ion. Evidence is presented that high blood lactate levels early in shock are indicative of poor prognosis.

Acidosis↗
PubMed1963

A new method of intestinal perfusion for the management of chronic renal failure; a preliminary report.

Usefulness of intestinal perfusion in the treatment of uremia is limited by (a) low clearances, (b) atrophy of the perfused mucous membrane, and (c) poor toleration by the patient. A method of intestinal perfusion has been devised which uses most of the small bowel without exclusion from the fecal stream. Two Roux-en-Y anastomoses are made, the proximal 12'' below the ligament of Treitz, the distal 18'' above the ileocecal valve. Perfusion is carried out between the proximal jejunostomy and distal ileostomy, daily. Six litres of fluid are perfused in four hours. The bowel is used for digestion during the remaining 20 hours of the day. Patients have solid bowel movements daily, prior to perfusion. Reflux of intestinal contents, between perfusions, is slight. The method allows maximal diffusion, may prevent bowel atrophy and is well tolerated by the patient. The method is being used, in conjunction with hemodialysis, in treatment of chronic uremia.

Anastomosis, Roux-en-Y↗