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J B Gardner

Publications and source records attributed to J B Gardner.

5 recordsLinked to original sources

Rupture in small abdominal aortic aneurysms.

BACKGROUND: The decision of whether to repair small abdominal aortic aneurysms (AAAs), which are those that are less than 5 cm in diameter, remains controversial. METHODS: We describe 161 consecutive patients who were seen at a single urban hospital with ruptured AAAs (rAAAs) and in whom aneurysm size was measured with ultrasound scanning, or rarely computed tomography, en route to the operating room. Eleven patients (6.8%) had AAAs that measured less than 5.0 cm. This group was compared with 150 patients who had rAAAs that were more than 5 cm. RESULTS: The mortality rates were similar in both of the groups 70% for small rAAAs versus 66% for large rAAAs. No significant differences were seen between the patients with small and large ruptured aneurysms with respect to the prevalence rates of hypertension (60% vs 50%) or of cardiac disease (20% vs 22%). However, the prevalence rate of obstructive lung disease was significantly different (64% vs 25%; P =.02) as was the rate of diabetes (28% vs 3%; P =.004). Five aneurysms were measured at exactly 5 cm. This suggests that approximately 10% of all aneurysms that rupture in this series do so at 5 cm or less. CONCLUSION: In view of the safety of elective repair as compared with the prohibitive risk associated with aneurysm rupture, patients who are at good risk with small AAA (between 4 and 5 cm) should be considered for elective aneurysm resection. For unclear reasons, obstructive lung disease and diabetes are associated with a significantly greater risk for rupture of small AAA. Patients with these risk factors should be given special consideration.

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Comparison of in vitro and in vivo models to assess venous irritation of parenteral antibiotics.

The venous irritation potential of four parenteral antibiotics, tetracycline hydrochloride (TET), erythromycin lactobionate (ERY), amphotericin B (AMP), and cephaloridine (CEP), was evaluated in an in vivo model using the rabbit ear vein. Lateral ear veins of New Zealand White rabbits were infused for 1 hr with test solutions containing TET (0.25,2.5, or 10 mg/ml), ERY (2.5, 5, or 25 mg/ml), AMP (0.05, 0.1, or 0.5 mg/ml), or CEP (4 or 20 mg/ml). Control rabbits received comparable volumes of 0.9% NaCl or 5% dextrose. Approximately 24 hr postinfusion, the rabbits were evaluated for visually evident changes in the treated ears. Pathologic evaluation of the veins was performed using histologic sections and scanning electron microscopy. TET, ERY, and AMP caused concentration-dependent changes in veins characterized primarily by loss of endothelium with associated inflammation and thrombus formation, consistent with the known clinical irritancy of these antibiotics. CEP, on the other hand, was well tolerated in the rabbit ear vein, paralleling its low irritancy potential in man. Test solutions identical to those used in vivo in rabbits were also evaluated in established in vitro assays for hemolytic potential when mixed with whole blood from monkeys and for damage to L6 muscle cells as determined by loss of creatine phosphokinase. Results of the in vitro test systems paralleled those of the rabbit ear model, with TET, ERY, and AMP exhibiting dose-dependent hemolysis and muscle cell toxicity, while CEP was comparatively nontoxic. Of the three models, the rabbit ear vein had the greatest sensitivity when histopathologic evaluation was employed.(ABSTRACT TRUNCATED AT 250 WORDS)

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