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Biomedical subjects

J B Gomensoro

Publications and source records attributed to J B Gomensoro.

At least 19 recordsLinked to original sources
PubMed1977

[Ischemic cerebral vascular pathology. History and updating].

This is a contribution to the memory of Professor Román Arana Iñíguez. He, with Professor Néstor Azambuja made possible our participation, in the Joint Study of Extracranial Arterial Occlusion from the National Institutes of Health, with 23 U.S. Universities. This research was started on March 1963 and ended on June 1971. It was directed by Dr. Arana, who gave impetus to our work and to our active participation on the subject at meetings held in Uruguay and abroad. A brief historiography of the subject is made, with emphasis in the chronology of our advances as compared to those of other leading countries.

Aged↗
PubMed1977

[Epidemiologic study of 500 adult epileptics from a hospital population].

An epidemiology analysis is carried out in a hospital population of 500 epileptic patients older than 14 years of age, pertaining to the outpatient department of the Instituto de Neurología, Hospital de Clínicas, Monevideo". This information gathered, corresponds to the period, 1966-1975. Specially formulated records of precoded-type data were used for this research and the data was processed by automation. This work deals fundamentally with a descriptive study in which the character of the population and of its epilepsy is studied by means of 20 items. Analyzed from within the social aspects, the school attendance and the occupation of the patients, amounts, similar to those of the general population of the country, were found. An elevated incidence of family epilepsy antecedents (17%) in the group and also of perinatal pathology (19%), is emphasized. An analytic study of the clinical type of crisis and of the factors unleashed by the attacks is made. Dividing the population into two groups, according to the beginning of epilepsy, before or after the 25 years, the different etiology for both groups is specially pointed out, the juvenile epilepsy predominating in the unknown etiology, genetics and that which is produced by perinatal pathology, while in the tary epilepsy, the vascular and tumoral etiology, above all, is most frequent.

Adolescent↗
PubMed1976

[5 years of experience in the treatment of parkinsonism with L-dopa and its combination with Ro4-4602].

Eighty-one Parkinsonic patients were treated with L-dopa alone and/or combined with Ro4-4602, during 27 to 60 months. The results are reported. 7.2% of the patients, who are still being treated, showed good, very good or excellent results. There was a relation between the duration of the illness and the degree of improvement, the most prolonged Parkinsonisms showed the least improvement. The 4:1 proportion of L-dopa and Ro4-4602 was more effective than the 3:2. Adding small amounts of L-dopa to the combinations improvement and secondary effects increased. No advantages were found using high combined dosages. The main secondary effects at the end of treatment were abnormal movements (45% of cases) and distonic attitudes (53%). Patients who stoped the medication showed less sustained improvement and a high degree of Parkinsonism. This reveals that Parkinson's disease continues to envolve in spite of the medication. The "long-term syndrome" includes the late decrease of effectiveness of the drugs and/or the increase of secondary effects.

Adult↗
PubMed1976

[Epidemiology of 500 adult epileptics from a hospital population].

On the basis of 500 epileptic patients treated in the Out-Patient Department of the "Instituto de Neurología", Hospital de Clínicas, Montevideo, Uruguay, an epidemiological study is undertaken. Data obtained correspond to the period extending between 1965 and 1975. A precodified data registering system was used and the analysis was done by mechanical processes. It is mainly a descriptive analysis of the group of patients and their seizures, including 20 items. As far as social aspects are concerned, education levels and occupation are analyzed, encountering similar levels as those of the general population in this country. As to etiological factors, a high incidence of familiar history of epilepsy (17%) and of perinatal pathology (19%) is found. An analytical study of the seizures and their provoking factors is performed. Etiological factors are analyzed dividing the patients in two groups according to the age of beginning of seizures (before or after 25 years) and in the younger groups perinatal factors and epilepsy of unknown origin predominate, while in the older group vascular and tumoral causes are more frequent.

Adolescent↗
PubMed1976

[Long-term syndrome in the treatment of parkinsonism with L-dopa and decarboxylase an inhibitor].

In 28% of patients treated for a long time with L-dopa, alone or combined with a decarboxilase inhibitor, the following "long-term syndrome" was observed: decrease in effectiveness, psychic disorders, intense abnormal movements, distonic attitudes, speech and gait disorders, orthostatic hypotension and/or general reprecussion. In 11% of the patients the "on-off" effect was studied (brisk alteranting Parkinsonic and improved states). Clinical observation during 14 hours a day was repeated with different dosages and different regimes of the drug; these modified the daily variations but did not eliminate the syndrome. The electromyographic studies also revealed the "on and off" phenomenon in different patients. When the "long-term syndrome" is severe, at times it is necessary to stop the drug; the secondary effects are thus decreased and, when the medication is given again, the therapeutic effectiveness is temporarily restored. When the drug is stopped the patients should be watched, since a "withdrawal syndrome" may appear.

Adult↗
PubMed1975

[Long-term syndrome in the treatment of parkinsonism with L-dopa].

A group of 71 patients with Parkinson's disease were treated with L-Dopa and benserazide during periods ranging from 27 to 60 months. In 28% of cases a decline in therapeutic effects and or delayed appearance or increase of secondary actions were observed constituting a long-term syndrome. Its most complex and dramatic expression, the on-off effect, was present in 11% of cases. Those patients with more severe symptoms were studied by means of continuous clinical observation enabling the design of daytime follow-up curves. Observations were repeated with varying dosage patterns, showing variations but no substantial changes or disappearance of the symptoms described. Electromyographic recordings and films were taken in certain cases defining the characteristics of on and off effects. Several procedures were implemented in an attempt to control Long-Term Syndrome manifestations: Change of dosage, variation of L-dopa/decarboxilase inhibitor ratio, association of anticholinergic agents with antidepressants, hypoprotein diets. Improvement was moderate and/or transient, with the exception of Nortriptilline which permitted total or partial control of certain symptoms, especially hypokinetic periods, bouts of tremor and dystonic attitudes. It was occasionally necessary to interrupt administration of L-Dopa, readministering it later with recovery of the therapeutic effect and/or avoidance of undesirable effects for varying periods of time. Loss than optimal doses proved beneficial in reducing or postponing Long-Term Syndrome manifestations. Although L-Dopa does not detain the course of the disease, the persistence of favourable results in most patients for prolonged periods of treatment confirms the long-term therapeutic value of this drug.

Benserazide↗